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Hydrogen bond receptor type spherical polymeric adsorbent and method for extracting puerarin

A technology for adsorbing resin and puerarin, applied in chemical instruments and methods, pharmaceutical formulations, other chemical processes, etc., can solve the problems of reduced adsorption selectivity, difficulty in obtaining high-purity puerarin products, etc., and achieve high selectivity and cost. Low, chemically stable effect

Inactive Publication Date: 2004-09-01
欧来良
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although this type of adsorption resin has considerable adsorption capacity, the adsorption selectivity is greatly reduced, so it is difficult to obtain high-purity puerarin products

Method used

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  • Hydrogen bond receptor type spherical polymeric adsorbent and method for extracting puerarin
  • Hydrogen bond receptor type spherical polymeric adsorbent and method for extracting puerarin
  • Hydrogen bond receptor type spherical polymeric adsorbent and method for extracting puerarin

Examples

Experimental program
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Effect test

Embodiment 1

[0014] Dissolve gelatin in water to make a 1% (w / w) aqueous solution. Stir and mix divinylbenzene: methyl acrylate: cyclohexanol = 1:1:1.5 and benzoyl peroxide (1% of the monomer amount), and the volume is equivalent to 1 / 4-1 of the water phase / 3), add it to the water phase, start stirring, raise the temperature (1°C / 2min) to 78-80°C, and keep it at this temperature for 3 hours after being finalized. Then the temperature was raised to 91-93° C., maintained for 5 hours, and then raised to 95° C., maintained for 4 hours. After the polymerization is completed, the material is discharged, fully washed with hot water, and a spherical hydrogen bond acceptor type adsorption resin with a particle size of 0.3-1 mm is prepared.

Embodiment 2

[0016] 20 grams of kudzu root (Guangxi Pueraria lobata) was pulverized, and 200 ml of 70% ethanol aqueous solution was used to reflux for 3 hours. After recovering the ethanol from the extract, it was diluted with water to 100-120 ml, and the clarified aqueous solution was filtered. The aqueous solution obtained is passed into the resin post (column diameter 15mm, 30ml resin is housed) of the spherical hydrogen bond acceptor type adsorption resin that is prepared in embodiment 1, and puerarin will be effectively adsorbed in the resin, and then After washing with 50-100 ml of deionized water and desorbing with 100 ml of 50% ethanol, the flow rate of adsorption, washing and desorption is 0.5 times of bed volume / hour. The desorbed solution is concentrated under reduced pressure, dried in vacuum and pulverized to obtain powdery puerarin extract. After high performance liquid chromatography analysis, the content of puerarin is more than 80%, and the yield is 1.0%.

Embodiment 3

[0018] Crush 20 kg of Pueraria lobata (Guangxi Pueraria lobata) and reflux with ethanol aqueous solution. After recovering ethanol from the extract, add water to dilute to 100-120 liters, and filter to obtain a clear aqueous solution. The aqueous solution that obtains is passed into the resin post (column diameter 80mm, 40 liters of resin is housed) of the spherical hydrogen bond acceptor type adsorption resin that is prepared in embodiment 1, and puerarin will be effectively adsorbed in the resin, After washing with 50-100 liters of deionized water, desorb with 150 liters of 50% ethanol, the flow rate of adsorption, washing and desorption is 0.5 times of bed volume / hour. The desorbed solution is concentrated under reduced pressure, dried in vacuum and pulverized to obtain powdered puerarin extract. According to high performance liquid chromatography analysis, the content of puerarin is more than 63%, and the yield is about 1.1%.

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Abstract

A spherical hydrogen-bond receptor type adsorptive resin for selective adsorption of solution and separation is disclosed. It can be used to extract puerarin from the plant through extracting in alcohol, adsorbing by the column of said adsorptive resin, washing, desorption, concentrating, drying and pulverizing. Its advantages are high purity (60-85%), simple process, low cost, and high quality of product.

Description

technical field [0001] The invention relates to a spherical hydrogen bond acceptor type adsorption resin, which utilizes a specific macroporous adsorption resin to extract and separate effective components of traditional Chinese medicines, and in particular relates to extracting puerarin, which has obvious curative effects on cardiovascular and cerebrovascular diseases, from the traditional Chinese medicine puerarin process method. Background technique [0002] As a special group of natural medicines, traditional Chinese medicine has been paid more and more attention by people. However, the biggest feature of traditional Chinese medicine that is different from Western medicine is that its active ingredients and mechanism of action are very complex and difficult to explain. This is also the crux of the long-term lack of breakthroughs in the modernization of traditional Chinese medicine. How to combine traditional Chinese medicine theory with modern science and technology ha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352B01J20/26C08F261/02
Inventor 欧来良
Owner 欧来良
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