Application of hydrogen saturated physiological saline in preparing medicines for preventing and treating abdominal aortic aneurysm

Abstract

The invention relates to an application of hydrogen saturated physiological saline in preparing medicines for preventing and treating abdominal aortic aneurysm. Animal experiments show that the hydrogen saturated physiological saline through intraperitoneal injection not only can improve inflammatory cell infiltration and reduce inflammatory mediator release, but also can relieve tissue peroxidation and enhance antioxidant enzyme activities, so as to reduce expression of vascular wall proteolytic enzyme and inhibit degradation of vascular elastic fiber, thus relieving vascular injury, inhibiting angiectasis and reducing maximum outer diameter of blood vessel. The hydrogen physiological saline is simple in preparation process, convenient to use, low in cost, and free from toxic and side effects; animal experiments show that the hydrogen physiological saline has good advantages in prevention and treatment; therefore, the invention develops a new application of the hydrogen saturated physiological saline in preparing medicines for preventing and treating abdominal aortic aneurysm.

Description

technical field [0001] The invention relates to the application of hydrogen-saturated physiological saline in the preparation of drugs for preventing and treating abdominal aortic aneurysm. Background technique [0002] Abdominal aortic aneurysms (AAA) is actually an arterial expansion disease caused by the degeneration of the arterial wall, rather than a "tumor" in the usual sense. However, it does not pose a threat to human health. less than any kind of malignant tumor. In recent years, the incidence of abdominal aortic aneurysm has been rising rapidly worldwide. In the United States, the incidence rate of abdominal aortic aneurysm has increased by 7 times compared with 30 years ago, reaching 2% to 7%, and about 15,000 people die from it every year, accounting for the 11th cause of disease death; The incidence rate of aneurysm is 4.5% to 5.9%, far exceeding the incidence rate of general malignant tumors; in my country, with the arrival of population aging social trend and...

AI Technical Summary

Problems solved by technology

The above-mentioned drugs have shown the potential effect of inhibiting the progression of abdominal aortic aneurysm, but while they play a therapeutic role, they inevitably bring certain side effects. Therefore, people have been devoting themselves to the research and development of more effective and safer drugs for the prevention and treatment of abdominal aortic aneurysm. drug

[0005] In 2007, Japanese scholars took the lead in reporting in "NAT MED" that breathing 2% hydrogen in rats can significantly improve cerebral ischemia-reperfusion injury. In vitro tests have proved that hydrogen can selectively neutralize hydroxyl radicals and nitrous acid in the solution Anions, and the latter two are the most important mediators that cause oxidative damage to cells. So far, no endogenous specific clearance pathway has been found in vivo

However, there is no relevant report about the application of hydrogen saturated saline in the preparation of drugs for the prevention and treatment of abdominal aortic aneurysms.

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