Method for preparing cancer cell targeted cell-like micro-capsules

A cell-mimicking and targeting technology, which is applied in the field of preparing cancer cell-targeting cell-mimicking microcapsules, can solve the problems of limited popularization and application, poor ability to target cancer tissues and cells, and poor biocompatibility, and achieve saving Raw materials, good targeting and killing of cancer cells, fast preparation effect
CN103585133AActive Publication Date: 2014-02-19ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2014-02-19

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Abstract

The invention discloses a method for preparing cancer cell targeted cell-like micro-capsules. Endothelial cells of human umbilical veins are used as raw materials for preparing cell-like micro-capsules with amino groups on surfaces, and the micro-capsules are dispersed in an aptamer solution containing aldehyde groups; after a certain period of incubation, aptamers are marked on the surfaces of the cell-like micro-capsules and then washed with a phosphate buffer solution; and the processed cell-like micro-capsules are immersed into a drug solution of doxorubicin hydrochloride, drugs are loaded through electrostatic interaction, and finally, the cell-like micro-capsules different in drug loading capacity are obtained. The preparation method is simple, controllable, wide in material source, high in production efficiency, capable of adjusting the drug loading capacity of the cell-like micro-capsules conveniently and providing the characteristics of target cancer cells simultaneously and good in application prospect.
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Description

technical field

[0001] The invention relates to a method for preparing cancer cell-targeted cell-like microcapsules. Especially the method of using nucleic acid aptamers to modify cell-like microcapsules to realize cancer cell targeting. Background technique

[0002] The targeting of drug carriers is a very important concept. The specific recognition of the drug carrier to cancer cells can increase the concentration of the drug in the tumor tissue, so the dosage can be significantly reduced, thereby reducing the toxic and side effects on normal tissues or cells. Therefore, realizing the targeting of drug carriers is of great significance in the field of drug delivery.

[0003] The usual drug carriers with targeting function mainly use artificially synthesized polymers or naturally derived proteins and polysaccharides as raw materials, and their structures are relatively simple. However, they often have poor biocompatibility, are easily recognized and cleared by the human ...

Claims

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