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Hydrophilic chiral separation polysulfone membrane, and making method and application thereof

A technology of chiral separation and polysulfone membrane, which is applied in organic chemical methods, chemical instruments and methods, membrane technology, etc., can solve problems such as flow, insufficient force, and low use efficiency, and achieve improved membrane hydrophilicity, The effect of firm force and stable performance

Active Publication Date: 2014-02-19
杭州绿益环境科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for common blended membranes, due to the insufficient force between the blended part and the membrane substrate, it is easy to pass away during use, resulting in the gradual weakening of the chiral resolution performance of the membrane, and the use efficiency is not high.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Preparation of Functional Blending Additive PSF-g-(PMMA-r-PAA)

[0053] Main chain P(SF-N 3 ) synthesis: 1 weight part of polysulfone (S3010 type polysulfone from BASF, Germany, with a shear molecular weight of 50000Da) was dissolved in 20 weight parts of CH 2 Cl 2 In, sequentially add 0.8 parts by weight of paraformaldehyde, 0.01ml of SnCl 4 and 2ml (CH 3 ) 3 SiCl was condensed and stirred at 50°C for 72 hours. After the reaction was completed, it was precipitated in methanol, filtered, dissolved in chloroform, reprecipitated in methanol, freeze-dried overnight to obtain white powder P(SF-CH 2 Cl). Take 1 weight part of P(SF-CH 2 Cl) and 5 parts by weight NaN 3 React in DMF solution at room temperature for 12h. After the reaction is completed, precipitate in methanol and lyophilize overnight to obtain white powder P(SF-N 3 ).

[0054] Synthesis of hydrophilic side chains: Take 80 parts by weight of acrylic acid (AA), 80 parts by weight of toluene, 1 part by w...

Embodiment 2

[0060] Example 2: Preparation of hydrophilic chiral resolution polysulfone membrane

[0061] (1) The preparation of the functional blending additive PSF-g-(PMMA-r-PAA) is the same as in Example 1.

[0062] (2) 1 part by weight of functional blending additive PSF-g-(PMMA-r-PAA), 5 parts by weight of PVP5000 (Aladdin Reagent Co., Ltd.), 20 parts of industrial polysulfone (S3010 polysulfone from BASF, Germany) Sulfone, with a shear molecular weight of 50000Da), was dissolved in 150 parts by weight of NMP (Aladdin Reagent Co., Ltd.) to prepare a casting solution.

[0063] (3) Pour the casting liquid onto the glass plate, adjust the thickness to 150 μm, and scrape evenly.

[0064] (4) After standing in the air for 30s, immerse the glass plate in DMF / H at 20°C 2 In the mixed solvent of O=90 / 10, soak for 2 minutes, take out and immerse in pure water, soak for 2 hours, take out and vacuum dry to obtain a hydrophilic polysulfone membrane.

[0065] (5) Immerse 25mg of hydrophilic pol...

Embodiment 3

[0067] Example 3: Preparation of hydrophilic chiral resolution polysulfone membrane

[0068] (1) The preparation of the functional blending additive PSF-g-(PMMA-r-PAA) is the same as in Example 1.

[0069] (2) 2 parts by weight of functional blending additive PSF-g-(PMMA-r-PAA), 8 parts by weight of PEG2000 (Aladdin Reagent Co., Ltd.), 80 parts by weight of industrial polysulfone (S3010 type of BASF, Germany) Polysulfone, with a shear molecular weight of 50000 Da), was dissolved in 300 parts by weight of DMF to prepare a casting solution.

[0070] (3) Pour the casting liquid onto the glass plate, adjust the thickness to 100 μm, and scrape evenly.

[0071] (4) After standing in the air for 60s, immerse the glass plate in DMAc / H at 50°C 2 In the mixed solvent of O=50 / 50, soak for 60 minutes, take out and immerse in pure water, soak for 2 hours, take out and vacuum dry to obtain a hydrophilic polysulfone membrane.

[0072] (5) Immerse 50mg of hydrophilic polysulfone membrane i...

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Abstract

The invention belongs to the technical field of polymer membrane materials, and discloses a hydrophilic chiral separation polysulfone membrane, and a making method and an application thereof. The method includes the following concrete steps: dissolving 1-10 parts by weight of a functional blend additive, 3-30 parts by weight of a pore forming agent and 10-100 parts by weight of polysulfone in 100-500 parts of an organic solvent to obtain a membrane casting liquid; dumping the membrane casting liquid onto a glass plate, and striking to uniformity; allowing the obtained glass plate to stand, immersing the glass plate in a solidification bath to form a membrane, putting the membrane in water for immersion, taking out, and carrying out vacuum drying to obtain a hydrophilic polysulfone membrane; immersing the hydrophilic polysulfone membrane in a phosphate buffer solution containing 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide, taking out the hydrophilic polysulfone membrane, and putting the hydrophilic polysulfone membrane in a phosphate buffer solution containing aminocyclodextrin to obtain the hydrophilic chiral separation polysulfone membrane which can be used for separating racemes.

Description

technical field [0001] The invention belongs to the technical field of polymer membrane materials, in particular to a hydrophilic chiral separation polysulfone membrane and its preparation method and application. Background technique [0002] The molecular formula is the same, and the structural formula is also the same, but because the atoms are arranged differently in space, the two isomers are the relationship between the real object and the mirror image or the relationship between the left hand and the right hand. This property of matter is called chirality. Chirality is a common phenomenon in nature, and the basic substances that constitute organisms, such as amino acids and sugars, are chiral molecules. [0003] When a chiral compound enters a living body, its two enantiomers usually exhibit different biological activities. Molecular pharmacology studies have found that chemical drug enantiomers containing chiral factors have significant differences in pharmacologica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/68B01D69/02B01D67/00C07B57/00C07D233/64C07D209/20
Inventor 胡继文杨洋苗磊李妃吴艳刘国军林树东刘峰邹海良涂园园胡盛逾
Owner 杭州绿益环境科技有限公司
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