Lyophilized levofloxacin composition powder for injection
A technology of levofloxacin and freeze-dried powder injection, which can be used in freeze-dried delivery, drug combination, powder delivery and other directions, and can solve the problem of no chitosan-containing nanoparticle pharmaceutical dosage form.
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[0028] Example 1. Preparation of Esomeprazole Sodium Lyophilized Powder Injection for Injection, based on 1000 pieces.
[0029] 1. Prescription:
[0030] Esomeprazole Sodium 40g
[0031] Chitosan Nanoparticles 20g
[0032] Water for injection 2000ml
[0033] 2. Preparation process.
[0034] Weigh 20g of chitosan nanoparticles and slowly add them to 2000ml of water for injection, and stir while adding until dissolved.
[0035] Add 40g of esomeprazole sodium and stir to dissolve until clear.
[0036] Adjust the pH to 10-11, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, and then filter the drug solution through 0.45μm and 0.22μm microporous membranes to detect the content of intermediates, as per esomeprazole sodium per bottle Calculate the amount of 40mg.
[0037] It is filled according to the inspection requirements, and then sent to the freeze dryer after half-press stopper. After freeze-drying is completed, it is out of the box.
Example Embodiment
[0038] Example 2. Preparation of Esomeprazole Sodium Lyophilized Powder Injection for Injection, based on 1000 pieces.
[0039] 1. Prescription:
[0040] Esomeprazole Sodium 40g
[0041] Chitosan Nanoparticles 14g
[0042] Water for injection 2000ml
[0043] 2. Preparation process.
[0044] Weigh 14 g of chitosan nanoparticles and slowly add them to 2000 ml of water for injection, and stir while adding until dissolved.
[0045] Add 40g of esomeprazole sodium and stir to dissolve until clear.
[0046] Adjust the pH to 10-11, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, and then filter the drug solution through 0.45μm and 0.22μm microporous membranes to detect the content of intermediates, calculated as esomeprazole sodium per bottle Calculate the amount of 40mg.
[0047] It is filled according to the inspection requirements, and then sent to the freeze dryer after half-press stopper. After freeze-drying is completed, it is out of the box.
Example Embodiment
[0048] Example 3. Preparation of Esomeprazole Sodium Lyophilized Powder Injection for Injection, based on 1000 pieces.
[0049] 1. Prescription:
[0050] Esomeprazole Sodium 40g
[0051] Chitosan Nanoparticles 29g
[0052] Water for injection 2000ml
[0053] 2. Preparation process.
[0054] Weigh 29 g of chitosan nanoparticles and slowly add them to 2000 ml of water for injection, and stir while adding until dissolved.
[0055] Add 40g of esomeprazole sodium and stir to dissolve until clear.
[0056] Adjust the pH to 10-11, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, and then filter the drug solution through 0.45μm and 0.22μm microporous membranes to detect the content of intermediates, calculated as esomeprazole sodium per bottle Calculate the amount of 40mg.
[0057] It is filled according to the inspection requirements, and then sent to the freeze dryer after half-press stopper. After freeze-drying is completed, it is out of the box.
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