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A kind of method for preparing oil-soluble medicine slow-release capsule

A slow-release capsule and oil-soluble technology, which is applied in the field of preparing oil-soluble drug sustained-release capsules, can solve the problems of too fast release process, high toxicity and high drug cost, and achieves controllable release process, low production cost, and reduced drug concentration. Effect

Active Publication Date: 2015-08-26
CHANGZHOU YINGZHONG NANO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The main technical problems to be solved by the present invention are the disadvantages of high drug cost, too fast or too slow release process, and high toxicity in the existing drug sustained release process.

Method used

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  • A kind of method for preparing oil-soluble medicine slow-release capsule
  • A kind of method for preparing oil-soluble medicine slow-release capsule
  • A kind of method for preparing oil-soluble medicine slow-release capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Weigh 25.0g of deionized water and 0.5g of surfactant in a 100ml small beaker, heat and stir after dissolving, set the temperature at 100°C, add 6.6g of 30% SiO2 drop by drop 2 (particle size is 3nm) in a small beaker, stir vigorously to make it uniform and form SiO 2 Emulsion: Weigh 5.2g of Sudan Red III, 1.1g of petroleum ether with a dissolution range of 90-120°C, and 6.3g of sliced ​​paraffin wax with a dissolution range of 52-56°C, stir for 3 minutes to make it uniform; add the paraffin wax mixture to In the silicon dioxide emulsion, after vigorous stirring, the temperature was lowered for processing to form a Pickering emulsion.

[0033] Weigh 3.5g of Pickering emulsion, add 42.0g of silica sol (containing 0.6g of silicon dioxide) formed by sol-gel method and 4.5g of surfactant to further deposit and coat paraffin wax particles to form drug sustained release capsule.

[0034] After 6 hours, it was washed and filtered twice, and the powder was dried in a ventilat...

Embodiment 2

[0036] Weigh 25.0g of deionized water and 0.5g of surfactant in a 100ml small beaker, heat and stir after dissolving, set the temperature at 100°C, add 6.6g of 30% SiO2 drop by drop 2 (Particle size is 50nm) in a small beaker, stir vigorously to make it uniform and form SiO 2 Emulsion: Weigh 0.5mg of Sudan Red III, 0.1mg of petroleum ether with a dissolution range of 90-120°C and 12.6g of sliced ​​paraffin wax with a dissolution range of 52-56°C, stir for 3 minutes to make it uniform; add the paraffin wax mixture to In the silicon dioxide emulsion, after vigorous stirring, the temperature was lowered for processing to form a Pickering emulsion.

[0037] Weigh 3.5g of Pickering emulsion, add 42.0g of industrial-grade silica sol (containing 1.0g of silicon dioxide) and 4.5g of surfactant to further deposit and coat the paraffin particles to form drug sustained-release capsules.

[0038] After 6 hours, it was washed with water and filtered twice, and the powder was dried and col...

Embodiment 3

[0040] Weigh 25.0g of deionized water and 0.5g of surfactant in a 100ml small beaker, heat and stir after dissolving, set the temperature at 100°C, add 6.6g of 30% SiO2 drop by drop 2 (Particle size is 10nm) in a small beaker, stir vigorously to make it uniform and form SiO 2 Emulsion: Weigh 0.5mg of Sudan Red III, 0.1mg of petroleum ether with a dissolution range of 90-120°C and 12.6g of sliced ​​paraffin wax with a dissolution range of 52-56°C, stir for 3 minutes to make it uniform; add the paraffin wax mixture to In the silicon dioxide emulsion, after vigorous stirring, the temperature was lowered for processing to form a Pickering emulsion.

[0041] Weigh 3.5g of Pickering emulsion, add 42.0g of industrial-grade silica sol (containing 0.6g of silicon dioxide) and 4.5g of surfactant to further deposit and coat the paraffin particles to form drug sustained-release capsules.

[0042] After 6 hours, it was washed with water and filtered twice, and the powder was dried and col...

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Abstract

The invention relates to a method for preparing an oil soluble drug sustained release capsule, belonging to the technical field of pharmaceutical preparations. The method comprises the following steps: heating paraffin to a melting state, and then mixing paraffin and oil soluble drug solution to form mixed oily solution; mixing silicon dioxide hydrosol and a surfactant, and stirring and reacting for a period of time to form a mixed aqueous solution; heating the mixed aqueous solution to the highest value of a dissolving process of paraffin, stirring and dropwise adding the mixed oily solution at the same time when the temperature is constant, and then cooling the mixed solution to room temperature; mixing the silicon dioxide hydrosol and the surfactant to form a mixed solution, and adding the mixed solution obtained in the step 3 into the mixed solution and stirring; after reaction is finished, separating, washing by using deionized water and naturally airing to obtain a dried powdery substance; and collecting the powder to obtain the mono-dispersed oil soluble drug sustained release capsule. The method provided by the invention is low in production cost, and the prepared oil soluble drug sustained release capsule has the advantages of controlling release process, reducing the toxic and side effects and reducing drug concentration.

Description

technical field [0001] The invention relates to a method for preparing oil-soluble drug sustained-release capsules, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Nanocapsules, also known as nanocapsules, are microcapsules with nanometer dimensions, and their particle sizes range from 1 to 1000nm. In 1976, Birrenbach G first proposed the concept of nanocapsules, which aroused great attention from relevant scholars in various countries. After the 1980s, people applied nanocapsules to the medical field and found that nanocapsules have many unique properties. For example, in biomedicine, tissue engineering, and targeted drug delivery devices, drug-controlled release materials have potential utilization values . Advantages of controlled release include greater drug availability and better balanced drug concentrations in the body. Compared with other capsules, microcapsules have many characteristics that other capsules do not hav...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/66
Inventor 姜兴茂张涛彭海波刘星星
Owner CHANGZHOU YINGZHONG NANO TECH
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