Traditional Chinese medicine composition for treating asthma as well as preparation method and application thereof

The technology of a composition and a traditional Chinese medicine is applied in the field of traditional Chinese medicine composition for treating asthma and its preparation field, which can solve the problems of insufficient attention to both the root cause and anti-inflammatory and allergy treatment, insufficient variety of Chinese patent medicines, weak synthesis force, etc., and achieves improved efficacy , Simple to use, reducing the effect of recurrence

Active Publication Date: 2014-03-12

杭州华东医药集团康润制药有限公司

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AI-Extracted Technical Summary

Problems solved by technology

The medicine of modern medical treatment of asthma is mainly hormone, for bronchial smooth muscle, relieves bronchospasm, can only alleviate symptoms, can not remove the root cause of disease and side effect is big, for example CN101657214B (2013-01-09) discloses a kind of treatment and prevention of asthma, however can not remove the root of the disease

However, due to the weak synthesis of...

Abstract

The invention relates to a traditional Chinese medicine composition for treating asthma as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 18-22 parts of ephedra, 18-22 parts of ginseng, 36-44 parts of dioscorea nipponica makino, 10-12 parts of semen armeniacae amarae, 10-12 parts of mangnolia officinalis, 10-12 parts of pericarpium citri reticulatae, 18-22 parts of liquorice, 15-17 parts of radix bupleuri and 10-12 parts of folia perillae acutae. The traditional Chinese medicine composition has the effects of diminishing inflammation and resisting allergies to treat symptoms, strengthening the body resistance and enhancing the immunity to treat root causes, freeing the lung and relieving asthma, inducing sweat and dispelling exogenous evils, and regulating qi-flowing for eliminating phlegm as main functions aiming at an attack stage and a remittent stage of qi-deficiency cold asthma, and strengthening the body resistance and tonifying spleen as auxiliary functions, so as to treat both symptoms and root causes.

Application Domain

Respiratory disorderPlant ingredients

Technology Topic

Anti-inflammatoryAsthma +14

Image

Examples

Experimental program(12)

Example Embodiment

[0181] Example 1: Preparation of granules

[0182] a) The volatile oil is extracted with steam distillation of 333g tangerine peel, 483g Bupleurum and 333g perilla leaves, and the volatile oil is covered with 10 times the amount of β cyclodextrin to obtain the first inclusion compound;

[0183] b) Use 7 times 70% ethanol as a solvent for 600g ephedra, 600g ginseng, 1200g pangasius, and 333g magnolia officinalis. After immersing for 24 hours, leak, collect the leaked liquid, recover the ethanol under reduced pressure, and concentrate to 25℃. The density is 1.08-1.12, and the extract Ⅱ is obtained;

[0184] c) Combine the above seven herbs dregs with 600g licorice, add 10 times the amount of water to decoct twice, add 333g bitter almonds after boiling, 2 hours each time, filter the decoction, combine the filtrate, and concentrate to 80 ℃ when the relative density is 1.05-1.10, get the extract Ⅲ;

[0185] d) Combine extract Ⅱ and extract Ⅲ, and spray dry (inlet air temperature is 160℃, outlet temperature is 90℃) to obtain dry powder, which is dried into granules with the first clathrate and pharmaceutical excipients. , Packed in aluminum foil bags, 3g per pack, sterilized, ready to be obtained. Determination of ephedrine containing ephedra and ephedrine hydrochloride (C 10 H 15 NO?? HCl) 5.5mg/bag.

Example Embodiment

[0186] Example 2: Preparation of tablets

[0187] a) The volatile oil is extracted with steam distillation of 333g tangerine peel, 483g Bupleurum and 333g perilla leaves, and the volatile oil is covered with 10 times the amount of β cyclodextrin to obtain the first inclusion compound;

[0188] b) Use 7 times 70% ethanol as a solvent for 600g ephedra, 600g ginseng, 1200g pangasius, and 333g magnolia officinalis. After immersing for 24 hours, leak, collect the leaked liquid, recover the ethanol under reduced pressure, and concentrate to 25℃. The density is 1.08-1.12, and the extract Ⅱ is obtained;

[0189] c) Combine the above seven herbs dregs with 600g licorice, add 10 times the amount of water to decoct twice, add 333g bitter almonds after boiling, 2 hours each time, filter the decoction, combine the filtrate, and concentrate to 80 ℃ when the relative density is 1.05-1.10, get the extract Ⅲ;

[0190] d) Combine extract Ⅱ and extract Ⅲ, spray dry (inlet air temperature is 160°C, outlet air temperature is 90°C) to obtain dry powder, add the first clathrate and appropriate amount of auxiliary materials, dry into granules and sizing , Tablets, 0.3g per tablet, sterilized, ready. Determination of ephedrine containing ephedra and ephedrine hydrochloride (C 10 H 15 NO?? HCl) 0.56mg/tablet.

Example Embodiment

[0191] Example 3: Capsule preparation

[0192] a) The volatile oil is extracted with steam distillation of 333g tangerine peel, 483g Bupleurum and 333g perilla leaves, and the volatile oil is covered with 10 times the amount of β cyclodextrin to obtain the first inclusion compound;

[0193] b) Use 7 times 70% ethanol as a solvent for 600g ephedra, 600g ginseng, 1200g pangasius, and 333g magnolia officinalis. After immersing for 24 hours, leak, collect the leaked liquid, recover the ethanol under reduced pressure, and concentrate to 25℃. The density is 1.08-1.12, and the extract Ⅱ is obtained;

[0194] c) Combine the above seven herbs dregs with 600g licorice, add 10 times the amount of water to decoct twice, add 333g bitter almonds after boiling, 2 hours each time, filter the decoction, combine the filtrate, and concentrate to 80 ℃ when the relative density is 1.05-1.10, get the extract Ⅲ;

[0195] d) Combine extract Ⅱ and extract Ⅲ, spray dry (inlet air temperature is 160℃, outlet temperature is 90℃) to obtain dry powder, add the first clathrate to make granules by dry method, add 5% stearic acid Magnesium, mix well, fill in capsules, 0.45g each, sterilize, and get ready. Determination of ephedrine containing ephedra and ephedrine hydrochloride (C 10 H 15 NO?? HCl) 0.89mg/grain.

PUM

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