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Synthetic method of hydrophilic polymeric microspheres capable of selectively identifying tetracycline

A synthesis method and technology for polymerizing microspheres, which are applied in the field of synthesizing hydrophilic polymerized microspheres, can solve problems such as toxic side effects, less research, and organ lesions, and achieve good selectivity.

Inactive Publication Date: 2014-03-12
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Tetracycline antibiotics are widely used in the prevention and treatment of diseases in humans and animals. They are poorly digested and absorbed in the body, and most of them are excreted without participating in metabolism, resulting in their accumulation and enrichment in the environment. People consume tetracycline residues exceeding the standard for a long time After water and food, tetracycline will slowly accumulate in the human body, causing toxic and side effects on the human body, leading to lesions in various organs of the human body
However, at present, precipitation polymerization is mainly carried out in toxic solvents such as acetonitrile and toluene, while less research is carried out in non-toxic solvents such as ethanol and water.

Method used

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  • Synthetic method of hydrophilic polymeric microspheres capable of selectively identifying tetracycline
  • Synthetic method of hydrophilic polymeric microspheres capable of selectively identifying tetracycline
  • Synthetic method of hydrophilic polymeric microspheres capable of selectively identifying tetracycline

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0030] Experimental Example 1: Add 10 mg of HMIMs and HNIMs to 10ml centrifuge tubes, and then take 10 ml of tetracycline solutions with initial concentrations of 10, 30, 50, 80, 100, 120, 150, and 180 μmol / L Added to the centrifuge tube, put the centrifuge tube in three different temperature (298K, 308K and 318K) water baths and let it stand for 12.0 h. After adsorption, the supernatant was collected by centrifugation, and the concentration of unadsorbed tetracycline molecules was measured with an ultraviolet-visible spectrophotometer, and the adsorption capacity was calculated. Image 6 The results showed that: with the increase of temperature and concentration, the adsorption amount gradually increased, and finally reached the adsorption equilibrium, and the adsorption amount of tetracycline to the hydrophilic imprinted polymer was always greater than that of the hydrophilic non-imprinted polymer, which proved that there were a large number of imprinted polymers. hole.

experiment example 2

[0031] Experimental Example 2: Add 10 ml of tetracycline solution with an initial concentration of 80 μmol / L into a centrifuge tube, add 10 mg of HMIMs and HNIMs respectively, and place the centrifuge tubes in a water bath at 298 K for 10, 20, and 30 , 45, 60, 90, 120, 150, 180 and 240 minutes. After standing still, the supernatant was collected by centrifugation, and the concentration of unadsorbed tetracycline molecules was measured with an ultraviolet-visible spectrophotometer, and the adsorption capacity was calculated according to the results. Figure 7 The results showed that HMIMs and HNIMs had good adsorption kinetics for tetracycline, and the adsorption equilibrium was basically reached within 3.0 h.

experiment example 3

[0032] Experimental example 3: Aureomycin, cephalexin and ciprofloxacin were selected as antibiotic compounds for competitive adsorption. Prepare the above three antibiotics with a solubility of 100 μmol / L respectively. Take 10 ml of the prepared solution and add it to a centrifuge tube, add 10 mg of HMIMs and HNIMs respectively, and place the centrifuge tube in a 298 K water bath for 12 h. After the adsorption, the supernatant was collected by centrifugation, and the concentrations of various competitively adsorbed antibiotics that were not adsorbed were measured with a UV-Vis spectrophotometer. Figure 8 The results showed that the hydrophilic imprinted polymer had remarkable specific recognition for tetracycline, and its adsorption capacity was significantly higher than that of other antibiotics.

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Abstract

The invention relates to a synthetic method of hydrophilic polymeric microspheres capable of selectively identifying tetracycline, belonging to the technical field of environment function materials. The synthetic method provided by the invention prepares the hydrophilic molecularly imprinted polymer microspheres by a one-pot method by taking non-toxic and pollution-free ethanol as a green solvent, tetracycline as a template molecule, methacrylic acid as a functional monomer, styrene and trihydroxymethyl acrylate as cross-linking polymerization monomers and azodiisobutyronitrile as an initiator to imitate precipitation polymerization by means of adding a hydrophilic polymeric monomer hydroxyethyl methylacrylate in a delay manner. The invention provides a simple one-pot method to synthesize the hydrophilic molecularly imprinted polymer microspheres with excellent performances, thereby providing a novel material and a green preparation method for selectively removing tetracycline residues in a water environment.

Description

technical field [0001] The invention relates to a method for synthesizing hydrophilic polymeric microspheres that can selectively recognize tetracycline, and belongs to the technical field of environmental material preparation. Background technique [0002] Tetracycline antibiotics are widely used in the prevention and treatment of diseases in humans and animals. They are poorly digested and absorbed in the body, and most of them are excreted without participating in metabolism, resulting in their accumulation and enrichment in the environment. People consume tetracycline residues exceeding the standard for a long time After drinking water and food, tetracycline will slowly accumulate in the human body, causing toxic and side effects on the human body, leading to pathological changes in various organs of the human body. Tetracycline residues in the ecological environment have been confirmed by domestic and foreign scholars. Therefore, it is particularly important to develop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F212/08C08F222/14C08F220/06C08F220/28C08F2/06C08J9/26B01J20/26B01J20/30
Inventor 戴江栋赵春艳宋志龙邹永立周志平闫永胜
Owner JIANGSU UNIV