Strong signal and low toxicity composite nanometer material and preparation method thereof

Abstract

The invention relates to a strong signal and low toxicity composite nanometer material and a preparation method thereof, and belongs to the technical field of material preparation, wherein Au-Cu2S quantum dots are adopted as an inner core, and ZnS is adopted as a shell to wrap the Au-Cu2S quantum dot inner core to prepare the Au-Cu2S / ZnS quantum dots. The preparation method comprises: preparing Au nanoparticles, preparing Au-Cu2S composite nanoparticles, and preparing Au-Cu2S / ZnS quantum dots. According to the present invention, the particle size of the obtained the composite nano-particles can be controlled in several nanometers to tens of nanometers, and the obtained the composite nano-particles can be used for cytotoxicity tests and biological labeling carriers or targeted drug delivery carriers, can be provided for observing fluorescence signals through a biological imaging system, can be combined with folic acid so as to provide biocompatibility, can further enter in vivo cells and be combined with the cells so as to be adopted as the biological probe marker to perform biological labeling, and can form the durg complex, wherein the durg complex can reside on the cancer cell surface.

Description

technical field

[0001] The invention belongs to the technical field of material preparation, and relates to a composite nanometer material and a preparation method thereof. Background technique

[0002] Nanoparticles refer to particles with a size between 1 and 100 nm. It is a group of atoms or molecules composed of a very small number of atoms or molecules. It is a field between macroscopic substances and microscopic atoms and molecules. It is a typical mesoscopic system. Its special structure causes it to have many unique properties, such as surface effect, small size effect, quantum size effect, macroscopic quantum tunneling effect, etc. Cu 2 As a new type of P-type semiconductor nanomaterial, S has a bandgap of about 1.2eV and its unique physical and chemical properties can be used as biological probes for in vivo and in vitro detection, and has been highly valued in the fields of biology and medicine. If the surface of a single quantum dot is coated with another sem...

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