Preparation method of vitamin C magnesium ascorbyl phosphate

Abstract

The invention discloses a preparation method of vitamin C magnesium ascorbyl phosphate. The preparation method is characterized by comprising the following process steps: (1), adding vitamin C, anhydrous calcium chloride and deionized water into a reaction kettle, adding sodium hydroxide aqueous liquor, and adding sodium trimetaphosphate to obtain vitamin C calcium ascorbyl phosphate; (2), adding the vitamin C ester calcium into a material barrel, washing by water, regulating pH value by sulfuric acid to obtain the vitamin C phosphate; (3), filtering the vitamin C phosphate by a roll type nanofiltration membrane filter; (4), adding the filtrate into a reaction kettle, passing through alkalescent anion exchange resin, eluting with hydrochloric acid, regulating pH with magnesium oxide to obtain vitamin C magnesium ascorbyl phosphate; and (5), passing the vitamin C magnesium ascorbyl phosphate through an active carbon filter, adding 95% alcohol in filtrate, spraying and drying to obtain a vitamin C magnesium ascorbyl phosphate finished product. According to the preparation method, an organic solvent is not adopted, whole process is simple and reaction time is shortened; moreover, the preparation method is safe to environment, and the finished product vitamin C magnesium ascorbyl phosphate is high in purity and good in stability.

Description

technical field [0001] The invention relates to the field of preparation of vitamin C derivatives, in particular to a preparation method of vitamin C magnesium phosphate. Background technique [0002] Magnesium vitamin C phosphate is a vitamin C derivative, which can improve the stability of vitamin C by derivatizing the 2-hydroxyl group into a phosphate ester, and the formed derivative can regenerate vitamin C after being hydrolyzed by phosphatase widely present in the body. Therefore, it has become the main ingredient of feed additives, food fortifiers and high-grade cosmetics whitening, and is a valuable fine chemical. [0003] So far, vitamin C phosphorylation mainly contains two methods: one is the phosphorylation of phosphorus oxychloride (as described in European Patent Nos. 388869 and 582924, U.S. Patent No. 4179445, Japanese Patent No. 60-69079, etc.), C is the raw material, and the hydroxyl groups on the 5- and 6-carbons are protected before esterification, that i...

AI Technical Summary

Problems solved by technology

Although the synthesis route of this method is short, there are many by-products, it is difficult to separate and purify the product, and the total yield of the product is low

The traditional synthetic process of vitamin C magnesium phosphate is complex, with many impurities, and the use of organic solutions such as acetone will cause damage to the environment

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