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Method for preparing whitening nanoparticle emulsion with solid phase core

A solid-phase core and nanoparticle technology, which is applied in pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve the problems of deterioration during product storage, easy oxidation of mandelic acid, and unstable chemical properties, etc. Increase shelf life, inhibit the formation of melanin, good water dispersibility

Active Publication Date: 2014-04-02
PROYA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Paeonol and daisy flower extracts have strong reducing properties and tend to turn yellow when exposed to oxygen; black tea seed oil is oxidized due to unsaturated bonds Afterwards, there will be a rancid taste, poor stability, and easy to be oxidized; mandelic acid will change color when exposed to light
Although the above four ingredients have an excellent effect on skin whitening, they are all unstable in chemical properties. If they are used directly in cosmetics, they will easily lead to deterioration of the product during storage.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A method for preparing a whitening nanoparticle emulsion with a solid-phase inner core, using the following steps:

[0022] A: Weigh 13.0g glyceryl stearate, 2.60g cetearyl ether-20, 2.60g cetearyl ether-12 according to the mass ratio of 5:1:1 and mix the above three substances as the oil phase , heated to 82°C;

[0023] B: Weigh 2.53g paeonol, 2.53g daisy flower extract, 7.57g black tea seed oil, 2.53g mandelic acid in a mass ratio of 1:1:3:1, and mix the above four substances , to obtain a whitening active composition;

[0024] C: Weigh 18.18g and 15.15g according to the mass ratio of 1.2:1, the oil phase obtained in steps A and B, and mix them uniformly at 82°C to form a uniform oily composition. In the present invention, the oil phase composition has a melting point of 48°C and is solid at room temperature;

[0025] D: Weigh 33.33g of the oily composition obtained in step C and 166.67g of deionized water at a ratio of 1:5, mix evenly at 82°C, and stir with a prop...

Embodiment 2

[0030] A method for preparing a whitening nanoparticle emulsion with a solid-phase inner core, using the following steps:

[0031] A: Weigh 13.90g of glyceryl stearate, 5.56g of cetearyl ether-20, and 2.78g of cetearyl ether-12 according to a mass ratio of 5:2:1, and mix the above three substances as an oil phase , heated to 83°C;

[0032] B: Take by weighing 2.22g paeonol, 4.44g daisy flower extract, 8.89g black tea seed oil, 2.22g mandelic acid in a ratio of 1:2:4:1 by mass, and mix the above four substances mixed to obtain a whitening active composition;

[0033] C: Weigh 22.22g and 17.78g according to the mass ratio of 1.25:1, the oil phase obtained in steps A and B, and mix them uniformly at 83°C to form a uniform oily composition. In the present invention, the oil phase composition has a melting point of 51°C and is solid at room temperature;

[0034] D: Weigh 40.0 g of the oily composition obtained in step C and 160.0 g of deionized water at a ratio of 1.25:5, mix ev...

Embodiment 3

[0039] A method for preparing a whitening nanoparticle emulsion with a solid-phase inner core, using the following steps:

[0040] A: Weigh 12.85g of glyceryl stearate, 7.71g of cetearyl ether-20, and 5.14g of cetearyl ether-12 according to a mass ratio of 5:3:2, and mix the above three substances as an oil phase , heated to 83°C;

[0041] B: Take by weighing 3.95g paeonol, 3.95g daisy flower extract, 9.88g black tea seed oil, 1.976g mandelic acid in the ratio of 2:2:5:1, and mix the above four substances mixed to obtain a whitening active composition;

[0042] C: Weigh 25.69g and 19.76g according to the mass ratio of 1.3:1, the oil phase obtained in steps A and B, and mix them uniformly at 83°C to form a uniform oily composition. In the present invention, the oil phase composition has a melting point of 46°C and is solid at room temperature;

[0043] D: Weigh 45.45g of the oily composition obtained in step C and 154.55g of deionized water at a ratio of 1.5:5, mix evenly at...

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Abstract

The invention relates to a method for preparing a whitening nanoparticle emulsion with a solid phase core. The method is characterized by adopting the following steps: A, weighing glyceryl stearate, ceteareth-20 and ceteareth-12, mixing and heating to 82-85 DEG C as an oil phase; B, weighing paeonol, daisy flower extract, ribes nigrum seed oil and mandelic acid, mixing to obtain a whitening active matter; C, weighing an oil phase and the whitening active matter, uniformly mixing at a temperature of 82-85 DEG C; D, adding deionized water, stirring at a rotating speed of 500rpm (revolutions per minute) by using a stirrer at a temperature of 82-85 DEG C for 10 minutes; E, homogenizing at a rotating speed of 15000-30000rpm by adopting a homogenizing machine, cooling to 70 DEG C at a speed of 0.5-1.5 DEG C per minute; F, cooling to a room temperature, adding a defined amount of anticorrosive agent to obtain the whitening nanoparticle emulsion with the solid phase core. The whitening nanoparticle emulsion with the solid phase core is capable of simultaneously loading the paeonol, the daisy flower extract, the ribes nigrum seed oil and the mandelic acid, is simple in preparation process, remarkable in whitening effect, and good in stability of the active matter.

Description

technical field [0001] The invention relates to the technical field of nanoparticle emulsion preparation, in particular to a method for preparing a whitening nanoparticle emulsion with a solid-phase inner core. Background technique [0002] Paeonol, CAS No.: 552-41-0, is an ingredient extracted from the dry root bark of the Chinese national flower peony, used in medicine for anti-allergic, anti-inflammation, and inhibition of intracellular oxygen free radicals Produced, has reducing properties, can restore melanin in cells to make it fade away. There are also chemically synthesized pure products. Daisy (BELLIS PERENNIS) flower extract, Chinese INCI name: Daisy flower extract, CAS number: 84776-11-4, as an endothelin antagonist, inhibits tyrosinase and promotes melanocyte differentiation by inhibiting endothelin function to reduce uneven pigment distribution. Ribes Nigrum Seed Oil (Ribes Nigrum Seed Oil), Chinese INCI name: Ribes Nigrum Seed Oil, CAS No.: 97676-19-2, conta...

Claims

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Application Information

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IPC IPC(8): A61K8/06A61K8/97A61K8/92A61K8/35A61Q19/02A61Q19/08
Inventor 蒋丽刚毕永贤
Owner PROYA COSMETICS
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