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Olive oil containing long-chain triglyceride injection and preparation method thereof

A technology for long-chain fat emulsion and olive oil, which is applied in the directions of medical preparations containing active ingredients, pharmaceutical formulas, and medical preparations with non-active ingredients, etc. The effect of low oxidation index, uniform milk grain size, and reduced oxidation level

Active Publication Date: 2014-04-02
GUANGDONG JIABO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to propose a long-chain fat emulsion injection containing olive oil. The injection has good stability and uniform emulsion particles, which solves the problems that the oxidation index of the emulsion particles is easy to exceed the standard and the problem of easy aggregation after long-term storage

Method used

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Examples

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Effect test

preparation example Construction

[0035] The present invention also discloses a preparation method of olive oil-containing long-chain fat emulsion injection, comprising the following steps:

[0036] 1) Filter the olive oil and soybean oil and put them into the preparation tank, turn on the masher to stir, and at the same time control the temperature at 30~60℃, add purified lecithin, mash until completely dissolved, then add oleic acid, continue to stir for 3~ 10min, to obtain the oil phase;

[0037] 2) Add glycerin and water for injection into the preparation tank, stir evenly, filter, and then add a pH regulator to adjust the pH value to 7.0~9.5 to obtain the water phase;

[0038] 3) Add the oil phase to the water phase and stir for 10-40 minutes to obtain the primary emulsion;

[0039] 4) Use a high-pressure homogenizer to homogenize the primary emulsion for more than 6 times to obtain a liquid medicine. The temperature during the homogenization process is 30-60°C, the primary pressure is 3000-8000psi, and ...

Embodiment 1

[0046] A preparation method containing olive oil long-chain fat emulsion injection, comprising the following steps:

[0047] 1) Filter 330g of olive oil and 70g of soybean oil and put them into the preparation tank, turn on the grinder to stir, and at the same time control the temperature at 30°C, add 40g of purified lecithin, grind until completely dissolved, then add 0.5g of oleic acid, continue Stir for 6min to obtain an oil phase;

[0048] 2) Add 40g of glycerin and an appropriate amount of water for injection into the preparation tank, stir evenly, filter, add water for injection to 2L, and then add a pH regulator to adjust the pH to 9.5 to obtain the water phase;

[0049] 3) Add the oil phase to the water phase and stir for 25 minutes to obtain the primary emulsion;

[0050] 4) Use a high-pressure homogenizer to homogenize the primary emulsion 14 times to obtain a liquid medicine, wherein the temperature during the homogenization process is 30°C, the primary pressure is...

Embodiment 2

[0053] A preparation method containing olive oil long-chain fat emulsion injection, comprising the following steps:

[0054] 1) Filter 320g of olive oil and 80g of soybean oil and put them into the preparation tank, turn on the masher and stir, while controlling the temperature at 40°C, add 30g of purified lecithin, mash until completely dissolved, then add 1.0g of oleic acid, continue Stir for 10 min to obtain an oil phase;

[0055] 2) Add 45g of glycerin and an appropriate amount of water for injection into the preparation tank, stir evenly, filter, add water for injection to 2L, and then add a pH regulator to adjust the pH value to 8.5 to obtain the water phase;

[0056] 3) Add the oil phase into the water phase and stir for 40 minutes to obtain the primary emulsion;

[0057] 4) Use a high-pressure homogenizer to homogenize the primary emulsion 10 times to obtain a liquid medicine, wherein the temperature during the homogenization process is 40°C, the primary pressure is 400...

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PUM

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Abstract

The invention discloses olive oil containing long-chain triglyceride injection. The injection comprises the following components: 140-170mg / ml of olive oil, 30-60mg / ml of soybean oil, 0.0002-0.0025mg / ml of oleic acid, 0.005-0.02mg / ml of purified lecithin and 20-28mg / ml of glycerinum, wherein the pH value of the injection is regulated to 7.0-9.5 by a pH regulating agent. The invention also discloses a method for preparing the olive oil containing long-chain triglyceride injection, which is simple in operation process, the product grains are uniform in side by controlling homogenizing pressure, time, temperature, nitrogenizing and other processes, the oxidation index, asepsis and other related indexes can reach standard, the product is good in stability, and the problems that oxidation index of grains easily exceeds the standard and the grains are easily aggregated when placed for a long time can be solved.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an olive oil-containing long-chain fat emulsion injection, and also relates to a preparation method of the olive oil-containing long-chain fat emulsion injection. Background technique [0002] As an important part of parenteral nutrition support, fat emulsion injection is an important source of energy, and at the same time provides essential fatty acids and fat-soluble vitamins, and has important metabolic functions. At present, the most clinically used fat emulsions are long-chain fat emulsions and medium-long-chain fat emulsions based on soybean oil. About 62% of the fatty acids contained in soybean oil are polyunsaturated fatty acids, and a large amount of polyunsaturated fatty acids will lead to immune cells. Reduced function and increased infection risk for patients. In addition, lipid overload, excess glucose, and bacterial proliferation caused by long-...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K36/48A61K47/12A61K47/24A61P3/02
Inventor 彭创业蔡文坚岳峰黄健鹏
Owner GUANGDONG JIABO PHARM CO LTD
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