Unlock instant, AI-driven research and patent intelligence for your innovation.

Collapse-resistance injection neutral bone cement and preparation method thereof

A bone cement and anti-collapse technology, which is applied in medical science, prosthesis, surgery, etc., can solve the problems of limited application, poor anti-collapse performance, strong acidity of bone cement, etc., and achieves simple preparation method, wide application range and good effect. Effect

Inactive Publication Date: 2014-04-02
SHANGHAI NAT ENG RES CENT FORNANOTECH
View PDF5 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Common curing fluids often have disadvantages such as poor collapse resistance and unsatisfactory mechanical strength when used to cure bone cement.
In addition, the solidification solution containing citric acid also has the disadvantage that the bone cement is strongly acidic, which seriously limits its further application.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Weigh 86 g of calcium hydrogen phosphate dihydrate and 25 g of calcium carbonate, add them to 165 mL of water, ball mill and mix well. Then the water was distilled under reduced pressure, and dried in a vacuum drying oven at 80° C. to obtain a mixed powder. The powder was fired in the middle of a furnace at 900°C for 15 hours, and then the main component of the bone cement powder was obtained by wet ball milling. 96 g of the main component of bone cement powder and 4 g of hydroxyapatite were uniformly mixed to obtain bone cement powder.

Embodiment 2

[0027] Weigh 86 g of calcium hydrogen phosphate dihydrate and 25 g of calcium carbonate, add them to 165 mL of water, ball mill and mix well. Then the water is distilled under reduced pressure, and dried in a vacuum oven at 80 degrees to obtain a mixed powder. The powder was fired in the middle of a furnace at 900°C for 15 hours, and then the main component of the bone cement powder was obtained by wet ball milling. The bone cement powder was obtained by mixing 91 g of the main component of the bone cement powder with 4 g of hydroxyapatite and 5 g of sodium silicate.

Embodiment 3

[0029] Weigh 1.0 g of sodium carboxymethylcellulose and add it to 99 mL of 20% citric acid aqueous solution for dissolution to obtain a solidified solution modified by sodium carboxymethylcellulose. The bone cement powder and curing liquid in Example 1 were mixed at a liquid-solid ratio of 0.5 mL / g, and the initial setting time was determined to be 8 min by referring to the standard ASTM C191. After putting the solidified bone cement block into water for 30 days, there was no obvious collapse phenomenon, and the solution was always neutral. After curing, the bone cement still kept its original shape after being placed in water for 30 days, and the collapsibility coefficient was 0.8%. When the bone cement is extruded in water with a syringe, the bone cement does not disintegrate in water. Its injectability factor is 50%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to collapse-resistance injection neutral bone cement and a preparation method thereof. The preparation method comprises the following steps: preparing citric solution with concentration of 3-55 percent; preparing sodium carboxymethylcellulose modified curing liquid with concentration of 0.01-2 percent based on the citric acid solution; storing the curing liquid in a 4 DEG C environment if the curing liquid is not used for a long time; and pre-dissolving before the curing liquid is used; and mixing the bone cement powder and the curing liquid according to a liquid-solid ratio to obtain the collapse-resistance injection neutral bone cement. Common defects of easy collapse, imperfect injection effect and strong acidity of bone cement in similar systems can be overcome, and the application range of related systems can be enlarged. The preparation method is simple, practical and good in effect, is suitable for popularization and application in different bone cement systems, and can be applied in a large scale.

Description

technical field [0001] The invention relates to a method in the technical field of biomedical materials, in particular to an anti-collapse, injectable neutral bone cement and a preparation method thereof. Background technique [0002] Calcium phosphate cement (CPC) is widely used as a new type of bone repair material because of its good biocompatibility, osteoconductivity, degradability and plasticity, and has attracted extensive attention from many scholars at home and abroad[Han Bing etc., Progress in Chemical Industry, 2006]. [0003] Bone cement generally consists of two parts: powder and curing liquid. Common solidification solutions usually contain disodium hydrogen phosphate, sodium dihydrogen phosphate, citric acid and other ingredients. In order to improve the strength of bone cement, reinforcing substances are often added, including fibers, gelatin, chitosan, polyglycolide (PLGA), hydroxyapatite whiskers, inorganic ceramic particles, etc. [Han Bing et al., Materi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/02A61L27/12A61L27/20A61L31/02A61L31/04
Inventor 刘涛杨迪诚何丹农
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH