Combined type method for extracting schisandrin b from fructus schisandrae

A technology of Schisandra chinensis B and Schisandra chinensis, applied in organic chemistry and other directions, can solve the problems of high extraction cost, long extraction time, large amount of solvent, etc., to improve the utilization rate, meet the needs of large-scale industrial production and excellent extraction effect. Effect

Inactive Publication Date: 2014-04-09
闵令杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, although researchers have developed many techniques for extracting schisandrin B, there are more or less problems in the existing extraction or separation techniques, such as large amount of solvent, long extraction time, high extraction

Method used

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  • Combined type method for extracting schisandrin b from fructus schisandrae
  • Combined type method for extracting schisandrin b from fructus schisandrae
  • Combined type method for extracting schisandrin b from fructus schisandrae

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1: the kind and consumption of additive in step A

[0044] A. Raw material pretreatment

[0045] Take 1kg of dried Schisandra chinensis, wash with warm water at 55°C, then filter, dry, and then crush through a 50-mesh sieve, then add different types and amounts of additives to the sieved powder, stir well and mix evenly, and then vibrate Grinding mechanically for 5-10 minutes to obtain Schisandra powder. Wherein, the type and dosage of additives are shown in Table 1 below.

[0046] B, preparation of compound extractant

[0047] Stir and mix the ionic liquid 1-butyl-2,3-dimethylimidazolium chloride and the auxiliary agent diethylene glycol dimethyl ether according to a weight ratio of 1:3, and then add ten Hexaalkyltrimethylammonium bromide, continue to stir at room temperature for 20 minutes, and mix evenly to obtain the required composite extractant.

[0048] C. Extraction operation

[0049] Weigh the schisandra powder of 100g of step A, add 800g of the...

Embodiment 2

[0060] Embodiment 2: Extract the kind of ionic liquid in step B

[0061] A. Raw material pretreatment

[0062] Take 1kg of dried Schisandra chinensis, wash with warm water at 60°C, then filter, dry, and then crush through a 60-mesh sieve, then add 3% sodium carbonate solid of dry Schisandra chinensis weight to the sieved powder, stir well and mix evenly Finally, mechanically pulverize with a vibrating mill for 5-10 minutes to obtain Schisandra chinensis powder.

[0063] B, preparation of compound extractant

[0064] Stir and mix different types of ionic liquids and additives diethylene glycol dimethyl ether according to a weight ratio of 1:3, then add cetyltrimethylammonium bromide equivalent to 4% of the weight of the ionic liquid, and continue at room temperature Stir for 25 minutes and mix evenly to obtain the desired compound extractant. Wherein, the types of ionic liquids are shown in Table 2 below.

[0065] C. Extraction operation

[0066] Weigh the schisandra powde...

Embodiment 3

[0073] Embodiment 3: the kind of auxiliary agent

[0074] A. Raw material pretreatment

[0075] Take 1kg of dried Schisandra chinensis, wash at 50°C, then filter and dry, crush and pass through a 70-mesh sieve, then add 3% sodium carbonate solid of dry Schisandra chinensis weight to the sieved powder, stir well and mix evenly Finally, mechanically pulverize with a vibrating mill for 5-10 minutes to obtain Schisandra chinensis powder.

[0076] B, preparation of compound extractant

[0077] Stir and mix the ionic liquid 1-butyl-2,3-dimethylimidazolium chloride and the additive according to the weight ratio of 1:3, and then add hexadecyl trimethyl bromide equivalent to 4% by weight of the ionic liquid ammonium, continue to stir at room temperature for 20 minutes, and mix well to obtain the desired composite extractant. Wherein, the types of auxiliary agents are shown in Table 3 below.

[0078] C. Extraction operation

[0079] Weigh the schisandra powder of 100g of step A, ad...

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Abstract

The invention relates to a combined type method for extracting schisandrin b from fructus schisandrae. The method comprises the steps of pretreatment of raw materials, preparation of compound extractant, extraction and separation and purification; the compound extractant formed by appropriate ionic liquid, assistant and hexadecyl trimethyl ammonium bromide is adopted, solid sodium carbonate is added for auxiliary extraction, and besides, microwaves and expanded solvent are adopted for complementary extraction, therefore, the method for extracting the schisandrin b from the fructus schisandrae with high yield is achieved finally, the material utilization rage is improved, waste discharge and environment pollution, caused by a great amount of organic solvents, are avoided, and wide industrial application prospect is achieved.

Description

technical field [0001] The invention belongs to the technical field of extracting active ingredients of medicines from natural plants. More specifically, the present invention relates to a compound method for effectively extracting schisandrin B from Schisandra chinensis, which has good prospects for industrial application. Background technique [0002] Schisandra chinensis is the mature fruit of the Magnoliaceae plant Schisandra chinensis, which contains a variety of active ingredients, such as lignans, triterpenes, sesquiterpenes, organic acids, volatile oils, etc. It has extremely high nutritional and medicinal value, and exhibits It has a variety of pharmacological effects on the nervous system, digestive system and cardiovascular system. In recent years, as an important component of Schisandra lignans, Schizandrin B has attracted much attention. It has a high content in lignans and a wide range of biological activities. Alanine aminotransferase, anti-cancer, antibacte...

Claims

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Application Information

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IPC IPC(8): C07D317/70
CPCC07D317/70
Inventor 闵令杰张永亮袁爱梅
Owner 闵令杰
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