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Chitosan multilayered gel balls and preparation method thereof

A technology of chitosan gel balls and multi-layer gels, applied in the field of material science, can solve problems such as unsatisfactory control of layer thickness, restrictions on the research and development of chitosan gel with multi-layer structures, and complex pretreatment. To achieve the effect of easy operation, simple operation and simple reaction equipment

Inactive Publication Date: 2014-04-09
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional method has defects such as unsatisfactory layer thickness control and complicated pretreatment.
The shortcomings of these traditional methods largely limit the further research and development of chitosan gels with multilayer structures

Method used

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  • Chitosan multilayered gel balls and preparation method thereof
  • Chitosan multilayered gel balls and preparation method thereof
  • Chitosan multilayered gel balls and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Add 1 mL of concentrated hydrochloric acid to 99 mL of deionized water, and stir evenly to obtain a hydrochloric acid solution with a volume fraction of 1% (v / v). Add 3.5g molecular weight 10 5 The chitosan was stirred evenly to obtain a chitosan-acetic acid mixed solution with a chitosan concentration of 3.5% (w / v). Add 2 g of sodium alginate powder into 100 mL of deionized water, stir at room temperature until completely dissolved, and obtain a sodium alginate solution with a concentration of 2% (w / v). Take a drop of chitosan solution with a dropper and add it dropwise to the sodium alginate solution, so that the chitosan droplet is completely immersed in the sodium alginate solution, and let it stand for 4 hours to obtain a chitosan wrapped by a polyelectrolyte film. The pellets are taken out with a medicine spoon and the excess sodium alginate solution on the surface is washed away with deionized water to obtain transparent chitosan pellets. Soak chitosan transpar...

Embodiment 2

[0042] Add 1mL of glacial acetic acid to 99mL of deionized water, stir evenly to obtain an acetic acid solution with a volume fraction of 1% (v / v), add 4g of acetic acid with a molecular weight of 2×10 5 The chitosan was stirred evenly to obtain a chitosan-acetic acid mixed solution with a chitosan concentration of 4% (w / v). Add 3 g of sodium alginate powder into 100 mL of deionized water, stir at room temperature until completely dissolved, and obtain a sodium alginate solution with a concentration of 3% (w / v). Take a drop of chitosan solution with a dropper and add it dropwise to the sodium alginate solution, so that the chitosan droplet is completely immersed in the sodium alginate solution, and let it stand for 5 hours to obtain a chitosan wrapped by a polyelectrolyte film. The pellets are taken out with a medicine spoon and the excess sodium alginate solution on the surface is washed away with deionized water to obtain transparent chitosan pellets. Soak chitosan transpar...

Embodiment 3

[0044]Add 2mL of glacial acetic acid to 98mL of deionized water, stir evenly to obtain an acetic acid solution with a volume fraction of 2% (v / v), add 3.5g of acetic acid with a molecular weight of 3×10 5 The chitosan was stirred evenly to obtain a chitosan acetic acid solution with a chitosan concentration of 3.5% (w / v). Add 2 g of sodium alginate powder into 100 mL of deionized water, stir at room temperature until completely dissolved, and obtain a sodium alginate solution with a concentration of 2% (w / v). Take a drop of chitosan solution with a dropper and add it dropwise to the sodium alginate solution, so that the chitosan droplet is completely immersed in the sodium alginate solution, and soak for 6 hours to obtain a small chitosan wrapped by a polyelectrolyte film. The ball is taken out with a medicine spoon and the excess sodium alginate solution on the surface is washed away with deionized water to obtain a chitosan transparent bead. Soak chitosan transparent beads ...

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Abstract

The invention discloses chitosan multilayered gel balls and a preparation method thereof, and belongs to the field of material science and technology. The preparation method comprises the following steps: dripping a chitosan acid solution into a sodium alginate solution while completely soaking chitosan drop into the sodium alginate solution; soaking a mixture into a NaOH solution after standing and washing, so as to obtain chitosan gel balls; repeatedly soaking the chitosan gel balls into deionized water and a NaOH solution, so as to obtain the chitosan multilayered gel balls. The chitosan multilayer gel balls with different layer quantities and different layer thicknesses can be obtained by controlling the concentration of the NaOH solution and soaking time. The preparation method disclosed by the invention has the advantages of no pollution, simple reaction instrument, temperate reaction conditions and the like, and is a method for inducing the inside of a soft material to generate an accurate and complex structure through external stimulation. The chitosan multilayered gel balls prepared by the invention have the advantages of complex internal structure and large surface area, and can be applied to various fields as a reaction template of nanometer particles.

Description

[0001] technical field [0002] The invention relates to a chitosan multilayer gel ball and a preparation method thereof, belonging to the technical field of material science. Background technique [0003] Chitosan is a natural polymer compound, also known as deacetylated chitin, which is obtained by removing part of the acetyl group from chitin, and its chemical name is polyglucosamine (1-4)-2- Amino-beta-D-glucose. Chitosan is the only weakly basic aminopolysaccharide existing in nature, with low toxicity and good biocompatibility. Due to the intermolecular hydrogen bonding, the acidic aqueous solution of chitosan has a certain viscosity, and it will form a gel when it encounters an alkaline reagent. The traditional preparation methods of chitosan hydrogel include physical cross-linking method or chemical cross-linking method. By chemical cross-linking method, chitosan molecular chains can be intertwined to form a supramolecular system of network structure. However, lig...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/07C08L5/08C08L5/04
Inventor 施晓文熊媛杜予民严坤刘红雨丁福源尚玉赵鹏坤
Owner WUHAN UNIV
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