Famotidine floating-adherent microtablet capsule and preparation method thereof
A famotidine and adhesion type technology is applied in the field of famotidine floating-adhesion microtablet capsules and preparation thereof, which can solve the problems of short residence time, inability to effectively improve the bioavailability of drugs, etc. The effect of retention time, improving oral bioavailability and simple preparation process
Active Publication Date: 2016-03-02
CHINA PHARM UNIV +1
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Problems solved by technology
Ordinary sustained-release preparations have too short residence time in the gastrointestinal tract, and many drugs pass through the absorption site without being released, so the bioavailability of the drug cannot be effectively improved
Method used
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Embodiment 1
[0017] Example 1 Preparation of 100 famotidine floating-adhesive microtablet capsules
[0018] prescription:
[0019]
[0020] Preparation method: pass famotidine and various auxiliary materials through 80-mesh sieve respectively, weigh famotidine and auxiliary materials according to the prescription amount, fully mix them according to the method of equal increment, sieve and mix evenly, and add appropriate amount of stearin by external addition method After fully mixing, the famotidine floating-adhesive microtablets were prepared by powder direct compression method.
[0021] Put the compressed micro-tablets into a suitable capsule shell to obtain the famotidine floating-adhesive micro-tablet capsules.
[0022] Take embodiment 1 as an example for illustration:
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Abstract
The invention discloses a famotidine floating-adhesive micro-tablet capsule and a preparation method thereof, belonging to the technical field of medicine. The preparation comprises famotidine, hydroxypropyl methylcellulose K4M, carbomer 971P, sodium bicarbonate, microcrystalline cellulose and magnesium stearate. A prepared famotidine floating-adhesive micro-tablet projects towards an outer circle, is 3 millimeters in diameter, and can be filled into a hollow hard capsule. The famotidine floating-adhesive micro-tablet can float in artificial gastric juice within 1 minute, floats continuously up to over 8 hours, and has certain adhesion. The release amount of the prepared famotidine floating-adhesive micro-tablet in 0.1M HCl solution within 1 hour is 50 percent less than a labelled amount. The preparation prolongs the retention time of famotidine in the stomach, so that the aims of reducing the administration times and enhancing the curative effect are fulfilled, and a novel selectable dosage form is provided for the development of a famotidine sustained-release preparation.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to a famotidine floating-adhesive microchip capsule and a preparation method thereof. Background technique [0002] Famotidine (FAM) is the third generation of H 2 Receptor antagonists, whose action strength is 30-100 times greater than cimetidine, 6-10 times greater than ranitidine, used for the treatment of stomach, duodenal ulcer and other acute gastrointestinal diseases, has the effect on Gastric mucosa H 2 With the characteristics of high receptor affinity, good effect, few adverse reactions, good patient tolerance and no influence on the metabolism of other drugs, it has become more and more widely used in clinical practice. However, famotidine is not completely absorbed in the gastrointestinal tract, and its oral bioavailability is only 40%-50%. Therefore, famotidine is made into a gastric retention preparation to prolong its residence time in the stomach, so as to achiev...
Claims
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IPC IPC(8): A61K9/48A61K31/426A61K47/36A61K47/38A61K47/02A61P1/04A61P1/00
Inventor 吴正红主雪华祁小乐邢嘉玉张子崴孟轩羽路显锋李浩冬许旭
Owner CHINA PHARM UNIV