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Slow-release preparation of Hainan holly leaf extract and preparation method of preparation

A slow-release preparation, the technology of mountain green tea, applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problem of single action of western medicine preparations, and achieve the effect of obvious antihypertensive effect, long duration and high content of active ingredients

Active Publication Date: 2014-04-16
广西万寿堂药业有限公司
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  • Abstract
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  • Application Information

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Problems solved by technology

[0005] In view of the above problems, the object of the present invention is to provide a slow-release preparation of camellia extract and a preparation method thereof to solve the problems of single action of western medicine preparations. Camellia is a Chinese medicinal material with obvious antihypertensive effect. The preparation has a "multi-target, multi-effect" effect, and has more advantages than western medicine preparations in treatment

Method used

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  • Slow-release preparation of Hainan holly leaf extract and preparation method of preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The technical scheme that present embodiment 1 adopts is as follows:

[0018] The sustained-release preparation of camellia green tea extract is composed of the following raw materials by weight percentage: 45% of camellia green tea extract, 25% of hydroxypropyl methylcellulose k100m, 25% of diluent, 4% of microcrystalline cellulose, stearin Magnesium acid 1%; the diluent is made of lactose and compressible starch in a mass ratio of 4:3.

[0019] Weigh 157.5g of camellia extract, 87.5g of hydroxypropyl methylcellulose k100m, 50g of lactose, 37.5g of compressible starch, and 14g of microcrystalline cellulose, and pass through a 100-mesh sieve respectively. Mix evenly by the method of equal increments, add a certain amount of soft material made of 80% ethanol, pass through a 20-mesh sieve to granulate, dry at 80°C for 1 hour, pass through a 20-mesh sieve for finishing, and add 3.5g of magnesium stearate to the total amount of granules Mix evenly, adjust the tablet press,...

Embodiment 2

[0021] The difference from Example 1 is that carboxymethyl cellulose (CMC) is selected as the skeleton material.

Embodiment 3

[0023] The difference from Example 1 is that polyvinylpyrrolidone (PVP) is selected as the skeleton material.

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Abstract

The invention discloses a slow-release preparation of a Hainan holly leaf extract and a preparation method of the preparation. The slow-release preparation of the Hainan holly leaf extract is prepared from the following raw materials by mass percent: 4-65% of Hainan holly leaf extract, 25-50% of framework material, 15-50% of diluent, 1-4% of filling agent, and 1% of lubricant. The method for preparing the slow-release preparation of the hainan holly leaf extract comprises the following steps: taking the raw materials according to the proportion; respectively screening by a 100mesh sieve, fully and evenly mixing; preparing a soft material by 60-80% ethanol; screening by a 10-30mesh sieve, and pelletizing; baking at 60-80 DEG C; straightening; adding 1% of magnesium stearate to evenly mix; and adjusting a tablet press to tablet, so as to prepare the slow-release preparation. The slow-release preparation prepared by the method is longer in pharmacologic action lasting time than a common hypotensive capsule and has a remarkable antihypertensive effect, the medicines in the preparation are slowly released at a non-constant speed, the administration frequency is obviously reduced, and the slow-release preparation is the slow-release preparation with significant curative effects.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations and preparations, in particular to a slow-release preparation of camellia japonica extract and a preparation method thereof. Background technique [0002] Mountain green tea is the leaf of the holly plant mountain green tea. Mountain green tea is mainly distributed in Guangxi and Guangdong. Mountain green tea is a folk Chinese herbal medicine of ethnic minorities in Guangxi and has a long history of use. Mountain green tea has the effects of clearing away heat and detoxification, reducing swelling and relieving pain, and promoting blood circulation. It is mainly used for lowering blood pressure, lowering blood fat, lowering cholesterol, hemiplegia caused by coronary heart disease and cerebrovascular accident, as well as anemopyretic cold, lung heat cough, throat edema, tonsillitis, dysentery and other diseases. According to "Xinhua Compendium of Materia Medica": "Mountain green tea, al...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K47/38A61K47/32A61P9/12
Inventor 慕丽群蒙永业李修善陈良
Owner 广西万寿堂药业有限公司
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