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A kind of preparation method of fluorescent gold nanoparticle

A technology of fluorescent gold nanoparticles and gold nanoparticles, which is applied in the field of fluorescent detection materials, can solve the problems of poor biocompatibility of gold nanoparticles, and achieve good biocompatibility, high fluorescence quantum yield, and simple preparation methods

Inactive Publication Date: 2016-06-22
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to commonly used sodium borohydride as reducing agent, other weak reducing agents such as tetrakis(hydroxymethyl)phosphonium chloride, dimercaptosuccinic acid, N,N'-dimethylformamide, 2 , 3-dimercaptosuccinic acid, N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid, 2-(N-morpholino)ethanesulfonic acid, etc. to prepare gold nanoparticles, these compounds are doing The reducing agent can also be used as a ligand to prevent the aggregation of gold nanoparticles, but most of the reducing agents / ligands used in the reported work are organic compounds, and the prepared gold nanoparticles have poor biocompatibility

Method used

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  • A kind of preparation method of fluorescent gold nanoparticle
  • A kind of preparation method of fluorescent gold nanoparticle
  • A kind of preparation method of fluorescent gold nanoparticle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take one fresh egg, take out the egg white and dilute it 5 times with distilled water, mix 10mL of egg white aqueous solution with 10mL of 10mmol / L chloroauric acid aqueous solution, 10mL of 100mmol / L sodium hydroxide aqueous solution, and use a 300W microwave oven to Heating for 3 minutes, standing at room temperature for 3 minutes, and then heating for 3 minutes to obtain fluorescent gold nanoparticles. The fluorescence emission peak of the gold nanoparticles is around 665nm, and when observed with a black background under natural light, it presents strong red fluorescence with a quantum yield of 7.3%.

Embodiment 2

[0020] Take one fresh egg, take out the egg white and dilute it 5 times with distilled water, mix 10mL of egg white aqueous solution with 10mL of 10mmol / L aurous chloride dilute hydrochloric acid solution, 20mL of 100mmol / L sodium hydroxide aqueous solution, and use Heated in a 300W microwave oven for 3 minutes, left at room temperature for 3 minutes, and then heated for 3 minutes to obtain fluorescent gold nanoparticles. The fluorescence emission peak of the gold nanoparticles is around 675nm, and when observed with a black background under natural light, it presents strong red fluorescence with a quantum yield of 3.0%.

Embodiment 3

[0022] Take one fresh duck egg, take out the duck egg white and dilute it 5 times with double distilled water, mix 10mL duck egg white aqueous solution with 10mL10mmol / L chloroauric acid aqueous solution, 10mL100mmol / L sodium hydroxide aqueous solution, and use 300W Heated in a microwave oven for 3 minutes, left at room temperature for 3 minutes, and then heated for 3 minutes to obtain fluorescent gold nanoparticles. The fluorescence emission peak of the gold nanoparticles is around 670nm, and when observed with a black background under natural light, it presents strong red fluorescence with a quantum yield of 5.9%.

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Abstract

The invention relates to a fluorescence gold nanoparticle and a preparation method thereof. The fluorescence gold nanoparticle is prepared according to a method including the following steps: mixing an egg white water solution, a gold salt water solution and a sodium hydroxide water solution; heating in a microwave oven for reaction; drying to obtain the fluorescence gold nanoparticle. The fluorescence gold nanoparticle is about 665 micrometers in fluorescence emission peak, appears to be strong red fluorescence when being observed with a black background under natural light, can reach 7.3% in fluorescence quantum yield, is 1.8 microseconds in fluorescence lifetime and can reach more than 12 mouths in room-temperature storage stability. The preparation method is simple, quick and environment friendly, a novel approach is provided for preparation of a fluorescence gold nano-material. The fluorescence gold nanoparticle can be applied to detection of mercury ions, and limit of detection is 3x10-11mol / L.

Description

technical field [0001] The invention relates to a fluorescent detection material, in particular to a fluorescent gold nano particle and a preparation method thereof, and the application of the fluorescent gold nano particle in detecting mercury ions. Background technique [0002] Gold nanoparticles are widely used in photoelectric devices and biosensors. Many scientists have done a lot of work in the preparation and application of gold nanoparticles. In addition to commonly used sodium borohydride as reducing agent, other weak reducing agents such as tetrakis(hydroxymethyl)phosphonium chloride, dimercaptosuccinic acid, N,N'-dimethylformamide, 2 , 3-dimercaptosuccinic acid, N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid, 2-(N-morpholino)ethanesulfonic acid, etc. to prepare gold nanoparticles, these compounds are doing The reducing agent can also act as a ligand to prevent the aggregation of gold nanoparticles, but most of the reducing agents / ligands used in the reported...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24C09K11/58G01N33/52G01N21/64B82Y40/00
Inventor 张彦高鹏飞蔡明发张国梅闫美芬双少敏董川
Owner SHANXI UNIV