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Double-layer tablet comprising proton pump inhibitor

A proton pump inhibitor, double-layer tablet technology, which can be used in medical preparations containing active ingredients, pill delivery, digestive system, etc., and can solve problems such as ineffectiveness of gastric acid

Inactive Publication Date: 2014-04-30
上海中邦斯瑞生物药业技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] But as is now known, PPIs have no effect on already secreted stomach acid

Method used

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  • Double-layer tablet comprising proton pump inhibitor
  • Double-layer tablet comprising proton pump inhibitor
  • Double-layer tablet comprising proton pump inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] immediate release tablet

[0028]

[0029] Extended release tablet

[0030]

[0031] preparation:

[0032] The immediate-release tablet cimetidine, microcrystalline cellulose, cross-linked PVP, sodium bicarbonate, and heavy magnesium oxide were respectively pulverized, mixed, and then added with magnesium stearate to mix evenly;

[0033] The sustained-release tablet omeprazole and sodium alginate were pulverized separately, sieved, mixed, and granulated by a fluidized bed; the rest of the materials in the sustained-release tablet were pulverized, sieved, granulated, dried, and granulated. Mix with the material obtained in step (2); and compress the material obtained in steps (1) and (3) into a double-layer tablet by a conventional double-layer tablet pressing method.

Embodiment 2

[0035] immediate release tablet

[0036]

[0037] Extended release tablet

[0038]

[0039] preparation:

[0040] The immediate-release tablet ranitidine, microcrystalline cellulose, cross-linked PVP, sodium bicarbonate, and heavy magnesium oxide were pulverized respectively, mixed, and magnesium stearate was added to mix evenly;

[0041] The pantoprazole and hypromellose in the sustained-release tablet are pulverized respectively, sieved, mixed, and granulated by a fluidized bed; the remaining materials in the sustained-release tablet are pulverized respectively, sieved, granulated, dried, and granulated. Granules are mixed with the material obtained in step (2); the material obtained in steps (1) and (3) is compressed into a double-layer tablet by a conventional double-layer tablet compression method.

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Abstract

The invention provides a double-layer tablet comprising a proton pump inhibitor. The double-layer tablet includes a fast-release tablet layer, a sustained-release tablet and a pharmaceutically acceptable excipient. The sustained release tablet layer contains a pharmacologically effective amount of the proton pump inhibitor or its salt; the a fast-release tablet layer contains an H2 receptor antagonist or its salt; and the pharmacologically acceptable excipient includes one or more of a filler, an adhesive, a lubricant and a surface active agent. In the invention, the H2 receptor antagonist as the fast release part reduces the secretion of gastric acid, and the proton pump inhibitor as the sustained-release part continuously suppresses the secretion of gastric acid, thereby effectively controlling the gastric pH value in a long time, prolonging the action time of drug and promoting the cure of diseases related to excessive acid.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a bilayer tablet comprising a proton pump inhibitor and an H2 receptor antagonist, a preparation method and application of the bilayer tablet. Background technique [0002] h + / K + - ATPase (H + K +- -ATPase) inhibitors, also known as proton pump inhibitors (PPIs), include the following compounds: omeprazole, lansoprazole, pantoprazole, rabeprazole ( rabeprazole), tenatoprazole, pariprazole, leminoprazole, and others. The active compounds can be used in neutral form or in the form of base salts, such as magnesium, calcium, sodium or potassium salts, a single enantiomer of the compound or its base salts, or It can be used in the form of solvates. These drugs work by irreversibly and specifically inhibiting H on the secretory surface of parietal cells. + K +- -ATPase enzyme system to inhibit gastric acid secretion. These active substances are useful for inhibiti...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K9/24A61P1/04
Inventor 侯玉军
Owner 上海中邦斯瑞生物药业技术有限公司
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