Mango leaf extract and application thereof

A mango leaf and extract technology, applied in the field of medicine, can solve problems such as prevention and treatment of undiscovered mango leaf extract

Active Publication Date: 2014-05-07
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

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Method used

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  • Mango leaf extract and application thereof
  • Mango leaf extract and application thereof
  • Mango leaf extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Example 1: Mango Leaf Extract

[0065] Take 10kg of mango leaves, dry them, grind them through an 80-mesh sieve, soak them in an appropriate amount of 75% ethanol for 24 hours, use 7 times the amount of 75% ethanol to heat reflux for 5 hours for the first time, and use 6 times the amount of 75% ethanol for the second time. Ethanol hot reflux extraction for 5 hours, the third time with 6 times the amount of 75% ethanol hot reflux extraction for 5 hours, combined extracts, filtered, the filtrate recovered alcohol, concentrated to a relative density of 1.00 ~ 1.20 (80 ℃) liquid Extract the clear paste with 4 times the amount of ethyl acetate for 4 times, take the water layer, centrifuge and filter at 8000 rpm, and dry it below 80°C to obtain 450g of mango leaf extract, containing 83% mangiferin and 0.6% mangiferin %.

Embodiment 2

[0066] Example 2: Mango Leaf Extract

[0067] Take mango leaves, dry them, powder them through an 80-mesh sieve, soak them in an appropriate amount of 95% methanol for 24 hours, use 7 times the amount of 95% methanol for hot reflux extraction for 5 hours for the first time, and use 6 times the amount of 95% methanol for the second time Heat reflux extraction for 5 hours, heat reflux extraction with 6 times the amount of 95% methanol for 5 hours for the third time, combine the extracts, filter, recover alcohol from the filtrate, concentrate to a clear paste with a relative density of 1.00-1.20 (80°C) ;Extract Liuqing paste 4 times with 4 times the amount of ethyl acetate, take the water layer, centrifuge filter at 1000 rpm, and dry below 80°C to obtain 500g of mango leaf extract, containing 56% mangiferin and 1.0% high mangiferin .

Embodiment 3

[0068] Example 3: Mango Leaf Extract

[0069] Take mango leaves, dry them, grind them through an 80-mesh sieve, soak them in an appropriate amount of 60% isopropanol for 24 hours, use 7 times the amount of 25% isopropanol to heat reflux for 5 hours, and use 6 times the amount for the second time Heat reflux extraction with 25% isopropanol for 5 hours, and heat reflux extraction with 6 times the amount of 60% isopropanol for 5 hours for the third time, combine the extracts, filter, recover alcohol from the filtrate, and concentrate to a relative density of 1.00-1.20 (80°C) Liuqing ointment; extract Liuqing ointment 4 times with 4 times the amount of butyl acetate, take the water layer, centrifuge and filter at 9000 rpm, and dry below 80°C to obtain 300g of mango leaf extract, containing mangiferin 70%, high mangiferin 0.05%.

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Abstract

The invention belongs to the field of medicines and discloses a mango leaf extract and application thereof. Mango leaves are subjected to refluxing extraction and concentration via aliphatic alcohol with 1-4 carbon atoms, and the obtained product is extracted and purified via low-polarity organic solvent and is refined to obtain the mango leaf extract. The mango leaf extract disclosed by the invention contains mangiferin and homomangiferin which are at specific proportion, and is better than a mangiferin monomer in the solubility. Pharmacological research proves that the mango leaf extract has the effects of lowering the level of serum uric acid of a hyperuricemia mice and reducing blood sugar, and is better than the mangiferin. Therefore, the invention provides application of the mango leaf extract provided by the invention to the medicine for preventing or treating the metabolic syndrome.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a mango leaf extract and its application. Background technique [0002] Metabolic syndrome (MS) is a pathological state of abnormal aggregation of various metabolic components. It may be related to insulin resistance (IR), and it has become a common focus of attention of cardiology and diabetes (DM) physicians. The clinical manifestations of metabolic syndrome include: abdominal obesity or overweight, atherogenic dyslipidemia (hypertriglyceridemia (TG) and high-density lipoprotein cholesterol (HDL-C) low), hypertension, insulin resistance and / or abnormal glucose tolerance, hyperuricemia and gout, these components are aggregated in the same individual, which greatly increases the risk of cardiovascular disease. The risk of poor clinical prognosis of multiple risk factors is greater than that of only one risk factor patients, and its effect is not simply added, but synergistically aggra...

Claims

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Application Information

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IPC IPC(8): A61K36/22A61K31/352A61P19/06A61P3/10A61P3/00A61K127/00
Inventor 张伟杨兆祥龚云麒高小惠宋立明杨旭娟
Owner KPC PHARM INC
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