Qingkailing lyophilized tablet and preparation method thereof

A freeze-dried tablet and freeze-dried technology, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of slow onset of action of Qingkailing tablets, and achieve short dissolution time and biological The effect of high utilization and broad application prospects

Inactive Publication Date: 2014-05-07
QIQIHAR UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved in the present invention is to solve the slow onset speed of the existing preparation of Qingkaili

Method used

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  • Qingkailing lyophilized tablet and preparation method thereof
  • Qingkailing lyophilized tablet and preparation method thereof
  • Qingkailing lyophilized tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0112] Example 1. Qingkailing freeze-dried tablets are made of raw and auxiliary ingredients including the following weight ratios:

[0113] Cholic acid 1.6 parts

[0114] Deoxycholic acid 2.2 parts

[0115] 12 servings of buffalo horn powder

[0116] 26 parts of mother-of-pearl

[0117] 14 parts of baicalin

[0118] Gardenia refined cream 12 servings

[0119] 56 parts of Radix Isatidis refined cream

[0120] 30 pieces of honeysuckle refined cream

[0121] Mannitol 80 parts

[0122] 80 parts of gelatin

[0123] Xanthan gum 30 parts

[0124] Sucrose 25 parts

[0125] Saccharin Sodium 1 serving

[0126] The preparation process is as follows:

[0127] 1) Decoction of honeysuckle, Radix Isatidis, and Mastizium, and then separately filter and combine the decoction filtrate, and concentrate the filtrate, alcohol precipitation, filtration, recover ethanol, concentrate the filtrate again, and pass through styrene type Or cross-linked polystyrene type macroporous resin column to chromatograph the conce...

Example Embodiment

[0134] Example 2. Qingkailing freeze-dried tablets are made of raw and auxiliary ingredients including the following weight ratios;

[0135] Cholic acid 1.6 parts

[0136] Deoxycholic acid 2.2 parts

[0137] 12 servings of buffalo horn powder

[0138] 28 parts of mother-of-pearl

[0139] 12 parts of baicalin

[0140] 14 servings of gardenia refined cream

[0141] 56 parts of Radix Isatidis refined cream

[0142] 30 pieces of honeysuckle refined cream

[0143] Sorbitol 80 parts

[0144] 80 parts gum arabic

[0145] Guar gum 30 parts

[0146] 30 servings of maltose

[0147] Stevia 1 part

[0148] The preparation process is as follows:

[0149] 1) Decoction of honeysuckle, Radix Isatidis, and Mastizium, and then separately filter and combine the decoction filtrate, and concentrate the filtrate, alcohol precipitation, filtration, recover ethanol, concentrate the filtrate again, and pass through styrene type Or cross-linked polystyrene type macroporous resin column to perform chromatography on the co...

Example Embodiment

[0156] Example 3. Qingkailing freeze-dried tablets are made of raw and auxiliary ingredients including the following weight ratios:

[0157] Cholic acid 1.6 parts

[0158] Deoxycholic acid 2.2 parts

[0159] 12 servings of buffalo horn powder

[0160] 26 parts of mother-of-pearl

[0161] 14 parts of baicalin

[0162] Gardenia refined cream 12 servings

[0163] Isatis root refined cream 60 parts

[0164] 30 pieces of honeysuckle refined cream

[0165] Xylitol 80 parts

[0166] 80 parts gum arabic

[0167] 30 parts pectin

[0168] 30 servings of lactose

[0169] 1 serving of aspartame

[0170] The preparation process is as follows:

[0171] 1) Decoction of honeysuckle, Radix Isatidis, and Mastizium, and then separately filter and combine the decoction filtrate, and concentrate the filtrate, alcohol precipitation, filtration, recover ethanol, concentrate the filtrate again, and pass through styrene type Or cross-linked polystyrene type macroporous resin column to chromatograph the concentrated fil...

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Abstract

The invention provides a Qingkailing lyophilized tablet and a preparation method thereof and relates to a pure traditional Chinese medicinal preparation. The Qingkailing lyophilized tablet is prepared from cholic acid, hyodeoxycholic acid, nacre powder, buffalo horn powder, honeysuckle extract, cape jasmine extract, isatis root extract, baicalin and other auxiliaries (filler, a skeleton agent, bond, a flavoring agent and a solubilizer). The Qingkailing lyophilized tablet is simple in preparation of lyophilized solution, feasible in lyophilisation process and uniform and stable in product quality. The Qingkailing lyophilized tablet has the advantages of use convenience in using, transporting and carrying of lyophilized tablet, and the acting speed of the lyophilized tablet is superior to that of conventional tablets.

Description

technical field [0001] The invention relates to a pure traditional Chinese medicine preparation, in particular to a freeze-dried tablet and a preparation method thereof. Background technique [0002] The series of Qingkailing preparations developed from the ancient prescription Angong Niuhuang Pills by dismantling the formula and reducing the taste, currently have Qingkailing injection, Qingkailing powder injection, Qingkailing oral liquid, Qingkailing granules, Qingkailing Ling tablets and other dosage forms. Qingkailing Tablets have the effects of clearing heat, detoxifying, calming and calming the nerves, and are mainly used to treat acute and chronic hepatitis, severe cold, high fever and other diseases. However, each of the above dosage forms has some disadvantages. Disadvantages of Qingkailing Injection: 1. The medicinal ingredients of Qingkailing Injection contain chlorogenic acid that is unstable under visible light, etc., which may easily lead to deterioration of ...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K47/26A61K47/36A61K47/38A61K47/42A61K9/20A61P29/00A61P25/20A61P1/16A61P31/12A61P31/14A61K31/7048A61K35/56A61K35/32A61K31/575A61K35/618
Inventor 马舒伟刘兴艳殷华峰赵明王丽艳
Owner QIQIHAR UNIVERSITY
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