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Qingkailing lyophilized tablet and preparation method thereof

A freeze-dried tablet and freeze-dried technology, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of slow onset of action of Qingkailing tablets, and achieve short dissolution time and biological The effect of high utilization and broad application prospects

Inactive Publication Date: 2014-05-07
QIQIHAR UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved in the present invention is to solve the slow onset speed of the existing preparation of Qingkailing tablets, and provide a quick-acting Qingkailing freeze-dried tablet preparation and a preparation method thereof suitable for clinical use

Method used

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  • Qingkailing lyophilized tablet and preparation method thereof
  • Qingkailing lyophilized tablet and preparation method thereof
  • Qingkailing lyophilized tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0112] Embodiment 1, Qingkailing freeze-dried tablet, is made of the raw and auxiliary material composition that comprises following weight ratio:

[0113] Cholic acid 1.6 parts

[0114] Deoxycholic acid 2.2 parts

[0115] Buffalo horn powder 12 parts

[0116] 26 parts mother of pearl

[0117] Baicalin 14 parts

[0118] Gardenia Refined Cream 12 parts

[0119] Banlangen Refined Paste 56 parts

[0120] Honeysuckle Refined Paste 30 parts

[0121] Mannitol 80 parts

[0122] 80 parts gelatin

[0123] Xanthan gum 30 parts

[0124] 25 parts sucrose

[0125] Sodium saccharin 1 part

[0126] The preparation process is as follows:

[0127] 1) Decoct honeysuckle, Radix Isatidis, and Fructus Fructus respectively, then filter separately, combine the filtrate after decoction, concentrate the filtrate, precipitate with alcohol, filter, recover ethanol, concentrate the filtrate again, and pass through the styrene type Or the cross-linked polystyrene type macroporous resin colum...

Embodiment 2

[0134] Embodiment 2, Qingkailing freeze-dried tablets are made of raw and auxiliary materials comprising the following weight ratios;

[0135] Cholic acid 1.6 parts

[0136] Deoxycholic acid 2.2 parts

[0137] Buffalo horn powder 12 parts

[0138] Mother of Pearl 28 servings

[0139] Baicalin 12 parts

[0140] Gardenia refined ointment 14 parts

[0141] Banlangen Refined Paste 56 parts

[0142] Honeysuckle Refined Paste 30 parts

[0143] Sorbitol 80 parts

[0144] Gum Arabic 80 parts

[0145] 30 parts guar gum

[0146] Maltose 30 parts

[0147] Stevia 1 part

[0148] The preparation process is as follows:

[0149] 1) Decoct honeysuckle, Radix Isatidis, and Fructus Fructus respectively, then filter separately, combine the filtrate after decoction, concentrate the filtrate, precipitate with alcohol, filter, recover ethanol, concentrate the filtrate again, and pass through the styrene type Or the cross-linked polystyrene type macroporous resin column carries out chroma...

Embodiment 3

[0156] Embodiment 3, Qingkailing freeze-dried tablets, made of raw and auxiliary materials comprising the following weight ratio:

[0157] Cholic acid 1.6 parts

[0158] Deoxycholic acid 2.2 parts

[0159] Buffalo horn powder 12 parts

[0160] 26 parts mother of pearl

[0161] Baicalin 14 parts

[0162] Gardenia Refined Cream 12 parts

[0163] Banlangen Refined Paste 60 parts

[0164] Honeysuckle Refined Paste 30 parts

[0165] Xylitol 80 parts

[0166] Gum Arabic 80 parts

[0167] 30 parts of pectin

[0168] Lactose 30 parts

[0169] 1 part aspartame

[0170] The preparation process is as follows:

[0171] 1) Decoct honeysuckle, Radix Isatidis, and Fructus Fructus respectively, then filter separately, combine the filtrate after decoction, concentrate the filtrate, precipitate with alcohol, filter, recover ethanol, concentrate the filtrate again, and pass through the styrene type Or the cross-linked polystyrene type macroporous resin column carries out chromatogra...

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PUM

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Abstract

The invention provides a Qingkailing lyophilized tablet and a preparation method thereof and relates to a pure traditional Chinese medicinal preparation. The Qingkailing lyophilized tablet is prepared from cholic acid, hyodeoxycholic acid, nacre powder, buffalo horn powder, honeysuckle extract, cape jasmine extract, isatis root extract, baicalin and other auxiliaries (filler, a skeleton agent, bond, a flavoring agent and a solubilizer). The Qingkailing lyophilized tablet is simple in preparation of lyophilized solution, feasible in lyophilisation process and uniform and stable in product quality. The Qingkailing lyophilized tablet has the advantages of use convenience in using, transporting and carrying of lyophilized tablet, and the acting speed of the lyophilized tablet is superior to that of conventional tablets.

Description

technical field [0001] The invention relates to a pure traditional Chinese medicine preparation, in particular to a freeze-dried tablet and a preparation method thereof. Background technique [0002] The series of Qingkailing preparations developed from the ancient prescription Angong Niuhuang Pills by dismantling the formula and reducing the taste, currently have Qingkailing injection, Qingkailing powder injection, Qingkailing oral liquid, Qingkailing granules, Qingkailing Ling tablets and other dosage forms. Qingkailing Tablets have the effects of clearing heat, detoxifying, calming and calming the nerves, and are mainly used to treat acute and chronic hepatitis, severe cold, high fever and other diseases. However, each of the above dosage forms has some disadvantages. Disadvantages of Qingkailing Injection: 1. The medicinal ingredients of Qingkailing Injection contain chlorogenic acid that is unstable under visible light, etc., which may easily lead to deterioration of ...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K47/26A61K47/36A61K47/38A61K47/42A61K9/20A61P29/00A61P25/20A61P1/16A61P31/12A61P31/14A61K31/7048A61K35/56A61K35/32A61K31/575A61K35/618
Inventor 马舒伟刘兴艳殷华峰赵明王丽艳
Owner QIQIHAR UNIVERSITY
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