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Compound florfenicol pharmaceutical composition as well as preparation method and use thereof

A technology of florfenicol and its composition, which is applied in the field of compound florfenicol pharmaceutical composition and its preparation and application, to achieve the effects of enhancing therapeutic effect, saving breeding cost, and formulating reasonable prescriptions

Inactive Publication Date: 2014-05-14
SICHUAN LAIBANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing compound drugs can treat respiratory tract infections caused by specific pathogens

Method used

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  • Compound florfenicol pharmaceutical composition as well as preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take 250g of N-methyl-2-dimethylpyrrolidone and heat it to 80°C, add 100g of florfenicol and 100g of aminophylline injection-grade raw materials, stir to dissolve, set aside; take another 400g of propylene glycol, and heat to 60-80°C, add 9g of flunixin meglumine and 10g of local analgesic benzyl alcohol, stir to dissolve, cool to about 40°C, mix with the spare drug solution, add polyethylene glycol 400 to 1000ml, filter, potting , sterilized at 115°C for 30 minutes, ready to serve.

Embodiment 2

[0033] Take 250g of N-methyl-2-dimethylpyrrolidone and heat it to 80°C, add 100g of florfenicol and 100g of aminophylline injection-grade raw materials, stir to dissolve, and set aside; take another 400g of glycerin formal, Heat to 60-80°C, add 9g of flunixin meglumine and 10g of local analgesic benzyl alcohol, stir to dissolve, cool to about 40°C, mix with the spare drug solution, add 400 to 1000ml of polyethylene glycol, filter, Potting, sterilization at 115°C for 30 minutes, ready to serve.

Embodiment 3

[0035] Take 250g of N-methyl-2-dimethylpyrrolidone and heat it to 80°C, add 150g of florfenicol and 100g of aminophylline injection-grade raw materials, stir to dissolve, set aside; take another 400g of propylene glycol, and heat to 60-80°C, add 9g of flunixin meglumine and 10g of local analgesic benzyl alcohol, stir to dissolve, cool to about 40°C, mix with the spare drug solution, add polyethylene glycol 400 to 1000ml, filter, potting , sterilized at 115°C for 30 minutes, ready to serve.

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Abstract

The invention provides a compound florfenicol pharmaceutical composition which is a veterinary preparation prepared from the following raw material medicines in parts by weight: 100-250 parts of florfenicol, 100-150 parts of aminophylline and 8-10 parts of flunixin meglumine. According to the pharmaceutical composition provided by the invention, florfenicol, aminophylline and flunixin meglumine are combined in use, so that the curative effect is superior to that of a single preparation comprising the medicines. The pharmaceutical composition has synergistic interaction and can effectively treat porcine and bovine respiratory tract infection diseases caused by haemophilus parasuis and actinobacillus pleuropneumoniae. The compound florfenicol pharmaceutical composition is reasonable in compatibility and suitable for industrialized application.

Description

technical field [0001] The invention relates to a compound florfenicol pharmaceutical composition and its preparation method and application. Background technique [0002] With the improvement of scale and the increase of breeding density, respiratory infectious diseases have become an important class of infectious diseases that affect the healthy development of pig and cattle industries. The main symptoms are respiratory system syndrome, and the sick pigs are depressed and have fever. Difficulty breathing, panting, coughing, sneezing, mucus or purulent discharge from the nostrils, conjunctivitis, swollen eyelids, abdominal breathing, loss of appetite, slow growth, emaciation, increased death, etc., the direct and The indirect economic loss is huge. [0003] At present, some technicians compound 100ppm of Zhiyuanjing, 300ppm of aureomycin, 400ppm of amoxicillin, and 100ppm of florfenicol to treat respiratory tract infection, which has a good therapeutic effect. Patent appl...

Claims

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Application Information

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IPC IPC(8): A61K31/522A61K9/08A61P11/00A61P31/04A61P29/00A61K31/165A61K31/44A61K31/245A61K31/167A61K31/045
Inventor 张善江王方明
Owner SICHUAN LAIBANG PHARMA