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Synthesis method of uncarine and isorhynchophylline

A technology of isortynine and a synthesis method, which is applied in the field of synthesis of uricine and isorhynchine, can solve problems such as low yield of uricine and isortynine, and achieve the effect of high yield

Inactive Publication Date: 2014-05-14
惠铁军
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The synthetic method of existing rhynchophylline and isorhynchophylline has low yield of rhynchophylline and isorynchophylline

Method used

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Experimental program
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Effect test

Embodiment Construction

[0012] The present invention adopts the following technical solutions.

[0013] (1) Put tryptamine and loganin into a flask, add water and glacial acetic acid, and react at 60°C for 2 to 5 days. After the reaction, the solvent was distilled off under reduced pressure to obtain the product.

[0014] (2) Take the product obtained above, β-glucosidase, and react at 37°C for 2 to 5 days; after the reaction liquid is cooled, it is extracted with chloroform three times, the extracts are combined, dried over anhydrous magnesium sulfate, and the compound is obtained.

[0015] (3) Dissolve the above compound in methanol, add Pd / C mg, and place it in a hydrogenation reactor for hydrogenation at room temperature for 6 hours; after the reaction, remove the catalyst by filtration; add solid anhydrous sodium carbonate and dimethyl sulfate to the filtrate A methylation reaction was carried out; after the solvent was removed under reduced pressure, the mixture was separated through a...

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Abstract

The invention relates to a synthesis method of uncarine and isorhynchophylline, belonging to the technical field of synthesis methods. The synthesis method of uncarine and isorhynchophylline is high in yield. The method comprises the following steps: putting tryptamine and split-ring loganin into a flask, adding water and glacial acetic acid, and reacting at 60 DEG C for 2-5 days; after the reaction is finished, distilling out the solvent under reduced pressure to obtain a product; taking the product and beta-glucosaccharase, and reacting at 37 DEG C for 2-5 days; cooling the reaction solution, extracting with chloroform for 3 times, merging the extracting solutions, and drying with anhydrous magnesium sulfate to obtain a compound; dissolving the compound in methanol, adding Pd / C, and hydrogenating in a hydrogenation reaction kettle at room temperature for 6 hours; after the reaction is finished, filtering to remove the catalyst; adding solid anhydrous sodium carbonate and dimethyl sulfate into the filtrate to perform methylation reaction; and after removing the solvent under reduced pressure, and separating through a silica gel column to obtain the mixture.

Description

Technical field [0001] The present invention is a technical field of synthesis methods, especially for a synthesis method of hook vine and alien vine. Background technique [0002] Hangjo is a commonly used Chinese medicine in clinical clinical, and it is also the main medicine of some famous compounds such as Gastrodia Hook vine drink "The New Sea of Miscellaneous Diseases" and Antelope Hangjo Tang "The Calligraphy of Treatment of Treatment".The main active ingredients in the hook vine are hook vine and alien vine.Modern studies have proved that they have a variety of actives such as lowering blood pressure, anti -cardiac rhythm, diastolic smooth muscle, sedation, brain protection, and reversal of tumor drug resistance.The content of hook vine and alien vine is very low in hook vines. If artificial synthesis can be performed, it will avoid damage to resources.Although their structure does not look too complicated, it is not easy to build a thread structure with multiple hand -in...

Claims

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Application Information

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IPC IPC(8): C12P17/18
Inventor 惠铁军温永康
Owner 惠铁军