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Sericin sphere microcapsule preparation method

A sericin and microcapsule technology, applied in the field of biomedical materials, can solve the problems of restricting the development of block copolymer microcapsules, complex block copolymer synthesis process and high cost of block copolymer synthesis, achieving low price, Good stability and the effect of reducing pollution

Inactive Publication Date: 2014-05-28
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the synthesis process of block copolymers is relatively complicated, and organic solvents are almost always used.
This makes the synthesis cost of the block copolymer higher, and the use of organic solvents also has environmental problems.
In addition, the frequent use of organic solvents in the preparation of microcapsules further limits the development of block copolymer microcapsules in biological applications.

Method used

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  • Sericin sphere microcapsule preparation method
  • Sericin sphere microcapsule preparation method
  • Sericin sphere microcapsule preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Dissolve the purchased sericin powder to make a 0.1% solution;

[0028] (2) Prepare 30mmol / L zinc ion solution;

[0029] (3) Mix sericin solution and metal ion solution, and add sodium hydroxide solution dropwise while stirring until the pH value reaches 6.50;

[0030] (4) Put the above solution in a 45°C incubator to react and keep stirring;

[0031] (5) After reacting for a long enough time, the reaction solution is centrifuged and washed, and then dried in a drying oven (25-40°C) to obtain a solid substance, that is, sericin spherical microcapsules.

Embodiment 2

[0033] (1) Dissolve the purchased sericin powder to make a 0.2% solution;

[0034] (2) Prepare 50mmol / L calcium ion solution;

[0035] (3) Mix sericin solution and metal ion solution, and add sodium hydroxide solution dropwise while stirring until the pH value reaches 8.00;

[0036] (4) Put the above solution in a 45°C incubator to react and keep stirring;

[0037] (5) After reacting for a long enough time, the reaction solution is centrifuged and washed, and then dried in a drying oven (25-40°C) to obtain a solid substance, that is, sericin spherical microcapsules.

Embodiment 3

[0039] (1) Dissolve the purchased sericin powder to make a 0.5% solution;

[0040] (2) Prepare 80mmol / L calcium ion solution;

[0041] (3) Mix sericin solution and metal ion solution, and add sodium hydroxide solution dropwise while stirring until the pH value reaches 8.00;

[0042] (4) Put the above solution in a 45°C incubator to react and keep stirring;

[0043] (5) After reacting for a long enough time, the reaction solution is centrifuged and washed, and then dried in a drying oven (25-40°C) to obtain a solid substance, that is, sericin spherical microcapsules.

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Abstract

The invention provides a sericin sphere microcapsule preparation method which comprises the following steps: (1) preparing a sericin solution with certain concentration and a solution containing metal ions; (2) dropwise adding the solution containing the metal ions in the sericin solution, and regulating the pH value of a reaction system; (3) putting the solution obtained in the step (2) in a thermostat, reacting, and stirring continuously; (4) centrifugally separating the reacted solution in the step (3) to separate out sediment, and washing with deionized water; (5) putting the sediment obtained in the step (4) into a drying oven for drying to obtain a sericin sphere microcapsule. With the method provided by the invention, the sphere microcapsule is prepared through regulating the outside conditions like the concentration of the sericin solution, the concentration of the metal ions and the pH value in the system; the whole process is implemented in an aqueous solution, so that the pollution to the environment caused by organic solvents is reduced. The produced sphere microcapsule has the advantages of excellent stability, biocompatibility and biological activity, the sources of the raw materials are rich, and the sphere microcapsule has the characteristic of low cost.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a method for preparing sericin spherical microcapsule materials. Background technique [0002] Silk is composed of silk fibroin and sericin. Sericin is a kind of globulin, easily soluble in water, accounting for about 20%-30% of the total weight of silk. When silkworms make cocoons, sericin plays the role of bonding, so that two monofilaments are wrapped together to form cocoon threads. In the process of silk reeling and gray silk refining, it also protects silk fiber and gray silk, but due to the needs of silk making and textile technology, sericin is finally completely removed, so it is discharged in silk and silk manufacturers The waste water contains a large amount of sericin. How to develop and utilize this natural resource while reducing the pressure of sericin-containing wastewater on the natural environment is a very important issue. [0003] So far, the water solub...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02
Inventor 姚菊明蔡玉荣刘兆刚
Owner ZHEJIANG SCI-TECH UNIV