Preparation of a liquid proliposome composed of squalene and β-carotene and its base reduction and harm reduction

A technology of proliposome and carotene, which is applied in the chemical field, can solve the problems of liquid proliposome preparation technology and application reports, and achieve the effects of large surface area, strong air permeability and increased stability

Active Publication Date: 2016-04-13
CHINA TOBACCO GUANGXI IND +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] There is no report on processing these free radical scavengers into liquid proliposomes and scientifically placing them in hookah cigarette holders to scavenge gaseous free radicals (reduced radicals), let alone studies based on squalene and β-carotene Preparation technology and application report of liquid proliposome of synergistic composition

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Prepare each component according to the following parts by mass: 10 grams (g) of lecithin; Those skilled in the art can use other sources of squalene) 5 grams (g); Those skilled in the art can use 15 grams (g) of β-carotene from other sources; 8 grams (g) of glycerol; 7 grams (g) of hydroxymethyl starch, and 55 grams (g) of water.

[0049] The preparation steps are:

[0050] S1. Dissolving the composition of lecithin, squalene and β-carotene in glycerol to obtain a mixed system;

[0051] S2. Homogenize the mixed system obtained in S1 at high speed (2000r / min, stir for 30min) to make it fully mixed to obtain a homogenized mixed system;

[0052] S3, mix the stabilizer and water to obtain the aqueous solution of the stabilizer, add the aqueous solution of the stabilizer to the homogenized mixed system obtained in S2 and stir evenly to form a stable particle suspension to obtain the combination containing squalene and β-carotene liquid proliposomes.

Embodiment 2

[0054] The preparation steps are the same as in Example 1. Weigh 10 grams of soybean lecithin, 10 grams of squalene, and 10 grams of β-carotene dissolved in 8 grams of glycerol, homogenize at a high speed to make it fully mixed, then add 9 grams of hydroxyethyl starch and dissolve it in 53 grams of water The aqueous solution is stirred evenly to form a stable microparticle suspension, and the liquid proliposome containing the antioxidant squalene and β-carotene composition is obtained.

Embodiment 3

[0056] The preparation steps are the same as in Example 1. Weigh 10 grams of hydrogenated soybean lecithin, 15 grams of squalene, 5 grams of β-carotene dissolved in 8 grams of glycerol, homogenize at high speed to make it fully mixed, then add 5 grams of hydroxymethyl starch and dissolve in 57 grams of The aqueous solution of water is stirred evenly to form a stable microparticle suspension, that is, the liquid proliposome containing the composition of antioxidant squalene and β-carotene is obtained.

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PUM

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Abstract

The invention discloses a preparation method of squalene and beta-carotene composition liquid proliposomes and a method for reducing free radical and harm by adopting proliposomes. The liquid proliposomes is prepared through 5 to 10 parts of phospholipid, 5 to 10 parts of stabilizer, 8 to 15 parts of surface active agent, 20 to 40 parts of squalene and beta-carotene composition and the balance of water. The liquid proliposomes is placed into a hollow cylinder body with two ends being respectively provided with a waterproof and dustproof ventilate membrane, the hollow cylinder body is arranged in a cigarette filter tip of cellulose acetate fibers in the molding process of the cigarette filter tip to obtain a cigarette filter tip capable of reducing the harm of the cigarette, when a consumer smokes the cigarette, the smoke passes through the built-in liquid proliposomes, since the surface area of the liquid proliposomes is large, antioxidant is adequately contacted with mainstream smoke, so that the gas-phase free radical in the mainstream smoke can be effectively eliminated, and powerful technical support can be provided for solving the smoking and health problem.

Description

technical field [0001] The invention relates to the technical field of chemistry, and more specifically relates to a liquid proliposome containing a composition of squalene and β-carotene, a preparation method thereof, and an application in reducing bases and harms of hookah filters. Background technique [0002] Thousands of compounds produced by smoking and the harm caused by high concentration of free radicals to the human body have attracted widespread attention. Free radicals have the strongest effect on the body and are the most harmful. They can cause lung disease, heart disease and cancer. These free radicals can cause serious damage to smokers. Smoking produces high concentrations of free radicals, including relatively long-lived solid-phase free radicals, quinones and semiquinones, polycyclic aromatic hydrocarbons free radicals, and reactive oxygen free radicals produced by their reactions with oxygen such as superoxide anion (O 2 - ), hydrogen peroxide (H 2 o ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A24D3/14
Inventor 金亚波陈泽鹏江定心田兆福韦建玉邓宾玲胡亚杰孙建生白森蔡联合梁伟梁永进
Owner CHINA TOBACCO GUANGXI IND
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