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Paracetamol and dihydrocodeine tatrate tablet and preparation method thereof

A technology of dihydrocodeine and paracetamol, which is applied in the directions of pill delivery, respiratory system diseases, non-central analgesics, etc., to reduce adverse reactions

Inactive Publication Date: 2014-06-18
FUJIAN MINGLONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide a kind of aminophenol dihydrocodeine tablet containing dihydrocodeine tartrate, paracetamol as main component and preparation method thereof , the technical problem to be solved is to make it have analgesic, antipyretic and antitussive effects at the same time, and can reduce the occurrence of adverse reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0061] A preparation method of aminophenol dihydrocodeine tablet, comprising the following steps:

[0062] 1), weighing. Weigh paracetamol, dihydrocodeine tartrate, lactose, hypromellose, HPMC, magnesium stearate, pregelatinized starch, sodium starch glycolate in batches according to the prescription amount of each material, and put them in the raw material container Indicate the name, weight (gross weight, net weight), batch number, operator, date, etc. on it, and place it in the preparation room for preparation;

[0063] 2), mix in equal amounts. Mix the prescribed amount of dihydrocodeine tartrate in a stainless steel plate and the prescribed amount of pregelatinized starch in the container according to the equal-volume incremental method, and then pass through a 40-mesh sieve to obtain the mixture ① ; the mixture ① Fully mix with the prescribed amount of lactose (passed through a 60-mesh sieve first) in the container in an equal-volume incremental method, then pass thro...

Embodiment 1

[0079] Example 1, various analgesic effects. Take the optimal ratio as:

[0080] Acetaminophen 84.1 (%)

[0081] Dihydrocodeine tartrate 1.55 (%)

[0082] Lactose 3.4 (%)

[0083] Hypromellose 3.4 (%)

[0084] HPMC 0.46 (%)

[0085] Magnesium stearate 0.49 (%)

[0086] Pregelatinized starch 1.6 (%)

[0087] Sodium starch glycolate 5 (%).

[0088] 1. Postoperative analgesic effect.

[0089] The analgesic effect and adverse reactions of the compound preparation tablets-aminophenol dihydrocodeine tablets made according to the above method for 86 cases of non-laparotomy patients. The patient was orally administered 2 tablets / time after the operation (no other analgesics were given during the administration). The results show that paracetamol dihydrocodeine tablets have obvious analgesic and pain relief effects on most postoperative pain, such as most orthopedics, neck, lumbar and limb operations, general surgery thyroid, breast surgery, most urological Oral administratio...

Embodiment 2

[0099] Example 2, antitussive and antipyretic effects. Take the optimal ratio as:

[0100] Paracetamol 83.92 (%)

[0101] Dihydrocodeine tartrate 1.68 (%)

[0102] Lactose 3.36 (%)

[0103] Hypromellose 3.36 (%)

[0104] HPMC 0.47 (%)

[0105] Magnesium stearate 0.49 (%)

[0106] Pregelatinized starch 1.68 (%)

[0107] Sodium starch glycolate 5.04 (%).

[0108] According to the above-mentioned method, the compound preparation tablet-Acetaminophen Dihydrocodeine Tablets are used for moderate or above dry cough and / or antitussive, antipyretic effects and adverse reactions accompanied by fever. 32 patients were given paracetamol dihydrocodeine tablets 2 tablets / time, tid, po. Results: Among the 32 subjects, cough was significantly relieved in 17 cases, accounting for 53.13%, effective in 13 cases, accounting for 40.62%, and the total effective rate was 93.75%. 11 cases with fever were relieved after taking the medicine, and the effective rate was 100%. There were 2 case...

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PUM

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Abstract

The invention discloses a component ratio and a preparation method of a paracetamol and dihydrocodeine tatrate tablet. The preparation method comprises the following steps: adding auxiliary materials comprising pregelatinized starch, lactose, hydroxypropyl cellulose, HPMC, sodium carboxymethyl starch and magnesium to a prescription dose of main components comprising stearate dihydrocodeine tartrate and paracetamol, carrying out balanced mixing, granulating, drying, finishing, mixing, tabletting, and packaging the obtained material in an aluminum plastic. The tablet has analgesic, antipyretic and antitussive effects, has the advantages of fast efficacies and effectiveness, long action time, good safety, variety of curative effects, reduction of the occurrence of untoward effects, and very extensive clinical application, and is worthy of popularization and application.

Description

technical field [0001] The invention relates to a medicine and a preparation method thereof, in particular to an aminophenol dihydrocodeine tablet and an industrially applicable preparation method thereof. technical background [0002] With the continuous deepening of medical theoretical research, as a traditional compound preparation, it has its advantages in production. Although traditional analgesic compound preparations can effectively delay the absorption of drugs in the body, thereby stabilizing the blood drug concentration, reducing side effects, and improving the effectiveness, safety and compliance of medication, but in analgesia, antipyretic, Antitussives cannot achieve effective cooperation and reduce adverse reactions at the same time. Therefore, the study of a drug with comprehensive analgesic, antipyretic, and antitussive effects is highly valued by pharmacists and clinicians. [0003] Acetaminophen has analgesic and antipyretic effects, and can selectively i...

Claims

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Application Information

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IPC IPC(8): A61K31/485A61K31/167A61K9/20A61P29/00A61P11/14
Inventor 吴立模
Owner FUJIAN MINGLONG PHARMA
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