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Application of antibacterial peptide as preservative in preparing cosmetics

A technology of antimicrobial peptides and cosmetics, applied in the application field of antimicrobial peptides as preservatives in the preparation of cosmetics, can solve the problems of high irritation, high toxicity, and unsatisfactory safety, and achieve low irritation and safety High, good compatibility effect

Inactive Publication Date: 2014-07-02
广州舒泰生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most cosmetic companies use chemically synthesized preservatives, and chemically synthesized preservatives have the defects of high irritation and toxicity, and the safety is not very satisfactory.

Method used

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  • Application of antibacterial peptide as preservative in preparing cosmetics
  • Application of antibacterial peptide as preservative in preparing cosmetics
  • Application of antibacterial peptide as preservative in preparing cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The application of antiseptic in the preparation essence among the embodiment 1 is specifically as follows:

[0026] The formulation of the essence is shown in Table 1 below:

[0027] Table 1 Essence

[0028] farewell

serial number

Standard Chinese name

Raw material mass content (%)

Compounding percentage (%)

purpose of usage

A

1

Deionized water

92.66

100

solvent

A

2

Glycerin

5

100

moisturizer

B

3

honey extract

2

100

moisturizer

A

4

Disodium EDTA

0.15

100

Chelating agent

A

5

Sodium hyaluronate

0.1

100

moisturizer

C

6

fragrance

0.01

100

Fragrance

C

7

PEG-40 Hydrogenated Castor Oil

0.03

100

Solubilizers

c

8

Antimicrobial Peptides

0.05

100

preservatives

[0029] Operating process:

[0030] 1. Stir and heat phase A to ...

Embodiment 2

[0039] The application of antiseptic in the preparation emulsified system in embodiment 2 is specifically as follows:

[0040] The formula of moisturizing cream is as follows Table 2:

[0041] Table 2 Moisturizer

[0042]

Embodiment 3

[0052] Example 3: Minimum Inhibitory Concentration Test (MIC)

[0053] 1. Vaccination

[0054] The test bacteria were respectively inoculated on the slant of solid medium, the bacteria were activated at 37°C for 18-24h, and the mold was activated at 28°C for 48-72h.

[0055] 2. Preparation of bacterial suspension

[0056] Take a certain amount of activated test bacteria in Erlenmeyer flasks equipped with sterilized liquid medium, culture them in constant temperature shaking incubators at 37°C and 28°C for 24h and 48-72h respectively, and use them as the original bacterial solution. Bacterial physiological saline was used to make each original bacterial solution into a bacterial suspension containing 106-108 CFU / mL of bacteria.

[0057] 3. Determination of minimum inhibitory concentration (MIC)

[0058] In this experiment, Staphylococcus aureus was used as the indicator bacterium, and the MIC value of the antimicrobial peptide preservative samples was determined by the test ...

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PUM

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Abstract

The invention provides an application of an antibacterial peptide as a preservative in preparing cosmetics. The antibacterial peptide provided by the invention has the beneficial effects that 1) the antibacterial peptide provided by the invention has broad-spectrum antibacterial activity and can effectively inhibit Gram negative bacteria, Gram positive bacteria, saccharomycetes and moulds; 2) the antibacterial peptide has good compatibility with raw materials of almost cosmetics, and the bacteriostatic ability is not affected by surfactants, proteins and Chinese herbal medicine additives in the cosmetics; and 3) the product does not contain a methanol releaser, highly irritant organic halogen components or chemical synthetic components, so that the product is high in safety and low in irritation.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to the application of antibacterial peptides as preservatives in the preparation of cosmetics. Background technique [0002] Cosmetics refer to smearing, spraying or other similar methods that are spread on any part of the human body surface, such as skin, hair, nails, lips and teeth, etc., to achieve cleaning, maintenance, beauty, modification and change of appearance, or to correct human body odor, maintain Chemical industrial products or fine chemical products for the purpose of good condition. The use of cosmetics has a very long history. According to investigations, humans have begun to use cosmetics since the Paleolithic Age, which began about 50,000 years ago. In the past 30 years, the cosmetics industry in various countries in the world has developed rapidly, and the use of cosmetics by humans has become more and more common. Cosmetics have developed from luxury goods to daily nec...

Claims

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Application Information

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IPC IPC(8): A61K8/64A61K8/98A61Q19/00
Inventor 张晏万宇杨欣陈凡
Owner 广州舒泰生物技术有限公司
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