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New application of rabeprazole in pharmacy

A technology of rabeprazole and rabeprazole sodium, applied in the field of pharmaceuticals, can solve the problem of no substitutes, achieve the effect of reducing the area of ​​ulcers, reducing the area of ​​bleeding, and reducing the incidence of ulcers and bleeding

Inactive Publication Date: 2014-07-09
NANJING CHANGAO PHARMA SCI & TECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And within the time that can be met, there is no substitute for this class

Method used

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  • New application of rabeprazole in pharmacy
  • New application of rabeprazole in pharmacy
  • New application of rabeprazole in pharmacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Rabeprazole sodium prevents and treats animal experiments on digestive tract damage caused by non-steroidal antipyretic, analgesic and anti-inflammatory drugs (NSAIDs)

[0026] Thirty female C57BL / 6 mice, aged 10 weeks, with an average body weight of 20 grams, were selected. The mice were placed in a room with an air filtration device, the food was standard stick-shaped solid food, sterile filtered water was used, and small pieces of sterile kapok were used as bedding in the cage, and each mouse was placed in a cage. The indoor lights are turned on and off for 12 hours a day. After one week of adaptation, the mice were divided into 15 groups for the following experiments. Give mice a suspension of rabeprazole sodium 25mg / kg and calcium carbonate 50mg / kg, prepared from corn oil. Each mouse was gavaged with 0.1 ml, and the control group was gavaged with 0.1 ml corn oil. After the mice were given the above treatment for 24 hours, the treatment was repeated onc...

Embodiment 2

[0027] Embodiment 2 rabeprazole sodium anti-stress acute ulcer effect in rats

[0028] 1. Method:

[0029] 1.1 Replication of ulcer model and index of ulcer degree: select SD rats, half and half female, weighing 200-250 grams, and the animals are randomly divided into 3 experimental groups, 1 famotidine group and 1 blank control group. Fasted for 24 h before the experiment, and had free access to water. 30 minutes before water immersion stress in the experimental group, rabeprazole sodium (25mg / kg, 50mg / kg, 100mg / kg) was administrated into the stomach (ig) respectively, with a volume of 10ml / kg (the same below), and the famotidine group was ig Titin (100mg / kg), the above drugs were formulated with 5g / L carboxymethylcellulose solution to the required concentration before use. The blank control group ig corresponding volume of normal saline. Water temperature (23±1°C), immersion stress for 5 hours, sacrifice the animals, and observe the ulcers. Ulcer index was calculated acc...

Embodiment 4

[0049] Example 4 Clinical Experiment of Rabeprazole Sodium Treating the Occurrence of Ulcer Hemorrhage under Stress

[0050] 1. Selection of clinical patients

[0051] All cases had hematemesis and melena or positive fecal occult blood test confirmed by the typical medical history, and melena caused by some traditional Chinese medicine was excluded, all had dizziness, cold sweat, pale complexion, decreased blood pressure, increased heart rate, and decreased hemoglobin Wait for the performance of hemorrhagic shock. All cases were confirmed by gastroscopy. The cases were randomly divided into two groups, oral rabeprazole sodium group (treatment group) and cimetidine injection (control group). The treatment group included 105 cases, including 73 males and 32 females; aged 58 to 80 years. Both groups of patients had acute massive bleeding for the first time, that is, ulcers were seen under the microscope and were bleeding, spurting blood or had fresh blood scabs. Except for pa...

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Abstract

A new application of rabeprazole in pharmacy. The invention belongs to the technical field of medicine, and relates to a new application of rabeprazole in medicaments for treating stress ulcer with bleeding.

Description

[0001] This application is a divisional application with a filing date of 2010.4.27, an application number of 201010156141.4, and an invention title of "New Application of Rabeprazole in Pharmaceuticals". technical field [0002] The invention belongs to the field of pharmacy, and relates to the treatment of acute gastric mucosal injury caused by non-steroidal anti-inflammatory drugs and the treatment of ulcer bleeding under stress, especially the use of rabeprazole in the production and treatment of non-steroidal anti-inflammatory drugs. Drug-induced acute gastric mucosal injury and the application of drugs in the occurrence of ulcer bleeding under stress. Background technique [0003] Rabeprazole or 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridine]methyl]sulfinyl]-1H-benzimidazole sodium. This compound belongs to the family of drugs known as proton pump inhibitors for the treatment of gastric and duodenal ulcers. Its structure is similar to that of other proton pump inhibito...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4439A61P1/04A61P7/04
Inventor 商明红李站李纬
Owner NANJING CHANGAO PHARMA SCI & TECH CO LTD
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