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Probiotic fermentation composition used for preventing and treating constipation

A fermented composition and technology of probiotics, applied in improving and improving its prevention and treatment of constipation, health food or medicine, food, Chinese medicine extracts fermented by intestinal probiotics, can solve problems such as many side effects

Active Publication Date: 2014-07-09
SANZHU FUER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, Western medicine mostly uses cathartics, prokinetic agents and other symptomatic treatments for constipation. Taking such drugs can only temporarily relieve the patient's symptoms, and there are many side effects and may cause drug dependence.

Method used

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  • Probiotic fermentation composition used for preventing and treating constipation
  • Probiotic fermentation composition used for preventing and treating constipation
  • Probiotic fermentation composition used for preventing and treating constipation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1: Preparation of fermented composition of traditional Chinese medicine compound by probiotic fermentation

[0031] Each Chinese medicine composition is taken by the following weight: (fried) cassia seed 100g, tangerine peel 100g, (fried) radish seed 50g, oat 20g. Add 8 times the amount of water to soak the traditional Chinese medicine for 50 minutes, extract at 100°C for 1 hour, filter, add 6 times the amount of water to the filter residue, extract at 100°C for 1 hour, filter and combine the filtrates, and concentrate under reduced pressure to 2:1~ 4:1 (that is, every 2-4ml extract is equivalent to 1g medicinal material). Dilute to 1000ml to obtain the Chinese medicine compound extract. Then add an appropriate amount of glucose (1.0%), peptone (0.4%), yeast powder (0.1%), yeast extract (0.2%), inorganic salt (FeSO 4 ·7H 2 O 1.0mg / 100ml, ZnSO 4 ·7H 2 O 4.4mg / 100ml, Na 2 SeO 3 ·5H 2 O 0.024mg / 100ml, MgSO 4 ·7H 2 O 70mg / 100ml, K 2 HPO 4 ·3H 2 O 100mg / ...

Embodiment 2

[0034] Example 2: small intestine propulsion experiment of fermented composition of the present invention and unfermented Chinese medicine compound extract

[0035] The purpose of this example is to use the mouse small intestine propulsion experiment to illustrate the comparison of the clinical effects of the fermented composition prepared by the method of the present invention and the unfermented traditional Chinese medicine compound extract.

[0036] The fermented composition prepared in Example 1 and the compound extract of traditional Chinese medicine without probiotic fermentation prepared in a similar manner were concentrated to the same concentration respectively as test samples.

[0037] 60 male mice weighing 18-22 g were randomly divided into 6 groups, 10 in each group, respectively blank control group, model control group, unfermented high-dose group, unfermented medium-dose group, fermented high-dose group, Fermentation medium dosage group. The test samples were gi...

Embodiment 3

[0050] Example 3: In vitro growth-promoting effect of the fermented composition of the present invention on intestinal probiotics

[0051] The purpose of this embodiment is to illustrate that the fermented composition prepared by the method of the present invention is selected from Bifidobacterium longum (B.longum), Bifidobacterium bifidum (B.bifidum) and Lactobacillus acidophilus (L.acidophilus) etc. In vitro growth-promoting effects of probiotics in the human gut.

[0052] Use Bifidobacterium longum, Bifidobacterium bifidum and Lactobacillus acidophilus as experimental bacteria, after the experimental bacteria are activated, use 0.1ml per tube (the bacterial concentration of the culture medium after inoculation is 10 6 each / ml) were inoculated in (1) conventional PTYG medium (each liter medium contains 5g of tryptone, 5g of soybean peptone, 10g of yeast extract, 10g of glucose, 40ml of salt solution, 0.5g of cysteine ​​hydrochloride, Tween 800.1ml, 0.1% resazurin 1ml); (2) fe...

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Abstract

The invention relates to the influence of probiotic to biological activity of a traditional Chinese medicine extract product, and especially relates to a method for enhancing, improving, preventing and treating constipation by the traditional Chinese medicine extract product through intestinal tract probiotic fermentation. The invention relates to a fermentation composition which is characterized in that (fried)cassia seed, dried orange peel, (fried)radish seed and an oat extract product enables intestinal tract probiotic fermentation, and prebiotics capable of promoting the growth of endogenous probiotics is added to prepare the fermentation composition, and an application of the fermentation composition is preparation of food, health food or medicine for preventing and treating constipation.

Description

technical field [0001] The invention relates to probiotics and their effects on the biological activity of Chinese medicine extracts, in particular to a method for improving and improving the method for preventing and treating constipation by fermenting Chinese medicine extracts with intestinal probiotics. The present invention further relates to a fermented composition prepared by (fried) cassia seed, tangerine peel, (fried) radish and oat extracts fermented by intestinal probiotics and adding prebiotics that promote the growth of endogenous probiotics, and the fermented composition The application of the substance in the preparation of food, health food or medicine for preventing and treating constipation. technical background [0002] Constipation refers to a disease in which the stool is blocked, the defecation time is prolonged, or there is a desire to defecate and it is difficult to expel. Constipation is divided into organic constipation and functional constipation. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K35/74A61P1/00A61P1/10A23K1/16A23K1/14A23L1/29A23L1/28A23L1/30A23L2/38A23L2/39A23K10/12A23L31/00A23L33/10A61K35/745A61K35/747
Inventor 褚新红孙筱林吴炳新牛纪江吕美
Owner SANZHU FUER PHARMA
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