Preparation method of effervescent tablet of pericarp and pomace extract of citrus Changshan-huyou
The technology of pomace extract and effervescent tablet is applied in the directions of medical preparations containing active ingredients, drug delivery, drug combination, etc., which can solve the problems of environmental pollution, excess production, slow increase in economic benefits of Changshan Huyou, etc. The effect of reducing environmental pollution, promoting utilization, and broad market prospects
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Embodiment 1
[0023] Embodiment 1: the preparation of pomelo peel pomace extract
[0024] 1) Take fresh Changshan pomelo peel and pomace, cut into pieces, oven-dried at 60°C and pulverized in turn to obtain powder;
[0025] 2) Take the powder obtained in step 1) and heat and reflux with 95% ethanol solution for three extractions, the first time is 2 hours, the second time is 1.5 hours, the third time is 1.5 hours, and the oily extract is obtained;
[0026] 3) The oily extract obtained in step 2) is mixed with petroleum ether at a volume ratio of 1:1 for extraction, repeated 5 times, and after extraction, the lower layer extract is taken to volatilize the petroleum ether to obtain the degreased extract;
[0027] 4) Take the degreased extract and use D101 macroporous resin for column chromatography, elute with ethanol with a concentration of 20-80%, collect the eluate, spin the eluent, and crush it to obtain Changshan Huyou peel pomace Extract powder.
Embodiment 2
[0028] Example 2: Preparation of effervescent tablets of pomelo peel and pomace extract
[0029] The Changshan Huyou peel and pomace extract powder obtained in Example 1 and the auxiliary materials, namely: citric acid, sodium carbonate, dextrin, and PEG-4000 were each passed through an 80-mesh sieve; the Changshan Huyou peel and pomace extract powder was divided into The two parts were mixed with citric acid and sodium carbonate respectively, dextrin was added to the acid-base system as a filler, absolute ethanol was used as a binder, and the acid-base separate granulation was carried out by 24-mesh granulation. Peel and pomace extract powder 5%, sodium carbonate 17.3%, dextrin 20%, mixed with absolute ethanol 2.25% as a binder, obtained by 24 mesh granulation; the alkali source is Changshan Huyou peel and pomace extract powder 5 %, 27.7% citric acid, 20% dextrin, mixed with 2.25% absolute ethanol as a binder, and obtained by 24 mesh granulation; put the acid-base granulation...
Embodiment 3
[0030] Example 3: Preparation of effervescent tablets of pomelo peel and pomace extract
[0031] The Changshan Huyou peel and pomace extract powder obtained in Example 1 and the auxiliary materials, namely: citric acid, sodium carbonate, dextrin, and PEG-4000 were each passed through an 80-mesh sieve; the Changshan Huyou peel and pomace extract powder was divided into The two parts were mixed with citric acid and sodium carbonate respectively, dextrin was added to the acid-base system as a filler, absolute ethanol was used as a binder, and the acid-base separate granulation was carried out by 24-mesh granulation. Peel and pomace extract powder 6%, sodium carbonate 18.5%, dextrin 17.5%, mixed with absolute ethanol 2.1% as binder, obtained by 24 mesh granulation; alkali source is Changshan Huyou peel and pomace extract powder 6 %, 29.5% citric acid, 17.5% dextrin, mixed with 2.1% absolute ethanol as a binder, and obtained by 24 mesh granulation; put the acid-base granulation int...
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