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Chitosan-modified pH responsive medicine-loading controlled release material and preparation method thereof

A technology of controlled release material and chitosan, which is used in pharmaceutical formulations, medical preparations with inactive ingredients, etc., to achieve the effects of large loading capacity, large pore volume and simple structure

Inactive Publication Date: 2014-07-16
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The present invention aims to overcome the defects of the existing methods for preparing chitosan-modified drug-loaded slow-controlled release materials. The invention provides a chitosan-modified pH-responsive drug-loaded slow-controlled release material and a preparation method thereof

Method used

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  • Chitosan-modified pH responsive medicine-loading controlled release material and preparation method thereof
  • Chitosan-modified pH responsive medicine-loading controlled release material and preparation method thereof
  • Chitosan-modified pH responsive medicine-loading controlled release material and preparation method thereof

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preparation example Construction

[0047] The preparation method of the drug-loaded slow-controlled release material uses mesoporous silica nanoparticles as the carrier, and after loading the drug, the chitosan polyelectrolyte membrane is surface-modified. The specific steps are as follows:

[0048] A) Drug loading on mesoporous silica nanoparticles

[0049] The drug solution is loaded into the pore structure of mesoporous silica nanoparticles through diffusion by physical impregnation method;

[0050] B) Chitosan modification on the surface of drug-loaded mesoporous silica nanoparticles

[0051] Method i) dispersing drug-loaded mesoporous silica nanoparticles into chitosan sol solution, stirring and standing to obtain drug-loaded mesoporous silica coated with chitosan;

[0052] Method ii) Interacting mesoporous silica nanoparticles with a silane coupling agent to activate the surface of mesoporous silica, after physically impregnating the activated mesoporous silica to load drugs, using active groups and chit...

Embodiment 1

[0070] Preparation of mesoporous silica nanoparticles directly coated with chitosan (Cs) and loaded with ibuprofen (IBU) (IBUMSNs-Cs-1)

[0071] Step A) Preparation of Mesoporous Silica Nanoparticles (MSNs)

[0072] 0.28g sodium hydroxide (NaOH) and 1.0g cetyltrimethylammonium bromide (C 16 TAB) was dispersed into 480 mL of deionized water and stirred vigorously at 80 °C for 1 hour. Afterwards, 5.0 mL of tetraethyl orthosilicate (TEOS) was added to the above mixture, and stirring was continued at 80° C. for 2 hours. After the reaction, the obtained white precipitate was centrifuged, washed with a large amount of ethanol, and then vacuum freeze-dried. Finally, the surfactant C in the pores of the prepared mesoporous silica was removed by ion exchange. 16 TAB: The dried sample (0.5 g) obtained above was dispersed into a mixed solution containing 95% ethanol aqueous solution and 0.2 g ammonium nitrate, and the mixture was magnetically stirred at 60° C. for 5 hours, and the pro...

Embodiment 2

[0079] Preparation of mesoporous silica nanoparticles bound to chitosan (Cs) and loaded with ibuprofen (IBU) (IBUMSNs-Cs-2)

[0080] Step A) Preparation of Mesoporous Silica Nanoparticles (MSNs)

[0081] According to step A) of Example 1, HMSNs were prepared;

[0082] Step B) Loading Ibuprofen (IBU) into MSNs

[0083] A simple physical impregnation method was used to diffuse ibuprofen (IBU) molecules into the mesoporous channels of MSNs. Disperse the MSNs obtained in step A) into ibuprofen n-hexane solution (40 mg / mL), and stir at room temperature for 24 hours in a dark environment. Afterwards, centrifuge the obtained suspension, wash off the IBU molecules adsorbed on the surface with a small amount of water, and dry at room temperature in vacuum to obtain MSNs loaded with IBU, which are labeled as IBUSNs;

[0084] Step C) γ-MPS modification on the surface of drug-loaded mesoporous silica (IBUMSNs)

[0085] Taking advantage of the fact that the surface of MSNs is rich in s...

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Abstract

The invention relates to a chitosan-modified pH responsive medicine-loading controlled release material and a preparation method thereof. The material consists of mesoporous silicon dioxide nano particles capable of loading medicines in mesoporous ducts and a chitosan-polymerized electrolyte membrane coating the mesoporous silicon dioxide nano particles. The preparation method comprises the following steps: dispersing the mesoporous silicon dioxide nano particles capable of loading medicines in the mesoporous ducts into chitosan sol, and stirring, separating, washing and drying to obtain the chitosan-modified pH responsive medicine-loading controlled release material.

Description

technical field [0001] The invention relates to a drug-loaded slow-controlled release material and a preparation method thereof, in particular to a chitosan-modified pH-responsive drug-loaded slow-control release material and a preparation method thereof. Background technique [0002] The death rate caused by malignant tumors has risen to the first place in our country, and its incidence is also increasing year by year. For malignant tumors, the main treatment methods are surgery, radiotherapy and chemotherapy. After nearly a century of continuous development and improvement, chemotherapy has become the most important means of comprehensive treatment of malignant tumors. However, the curative effect of chemotherapy has been at a low level at present. The main reason is that the amount of chemotherapy drugs is large, and most of the drugs lack the specificity of pharmacological activity. They have serious toxic and side effects on both cancerous and normal tissues. Allergic...

Claims

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Application Information

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IPC IPC(8): A61K47/04A61K47/36
Inventor 祝迎春符静珂
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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