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A high-sensitivity nano-cobalt oxide-doped amobarbital molecularly imprinted electrochemical sensor and its preparation method

A nano-cobalt oxide and isopentobarbital technology, which is applied in the direction of material electrochemical variables, can solve the problems of inappropriate matching of functional monomers, template molecules and cross-linking agents, low sensitivity, and poor cross-linking rigidity. , to achieve the effect of excellent sensitivity, simple equipment and easy production

Inactive Publication Date: 2016-06-08
GUANGXI UNIV FOR NATITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current method is not sensitive because the selected functional monomers, template molecules and cross-linking agents cannot be properly matched, and the rigidity of the cross-linking is also poor.

Method used

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  • A high-sensitivity nano-cobalt oxide-doped amobarbital molecularly imprinted electrochemical sensor and its preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 1. Treatment of glassy carbon electrodes

[0015] Polish the glassy carbon electrode on a polishing cloth with 1.0 μm, 0.3 μm and 0.05 μm alumina powder in sequence, then put it into nitric acid with a volume ratio of 1:1 for 6 minutes, then put it into absolute ethanol for 6 minutes, and finally Ultrasonic cleaning with pure water.

[0016] 2. Preparation of molecularly imprinted electrochemical sensor for paracetamol

[0017] To 10.0mL solvent ethanol, add 0.2mmol template molecule amobarbital, 1.8mmol functional monomer 20(s)-O-androst-4-ene-17β-acylcamptothecin, 3.5mmol Cross-linking agent maleic rosin ethylene glycol acrylate, 0.5 mmol initiator azobisisobutyronitrile and 0.0150 g of nano-cobalt oxide, each adding a chemical reagent ultrasonically dissolved for 8 minutes;

[0018] Take 5 μL of the mixture in step and apply it on the surface of a clean and smooth glassy carbon electrode. After standing for 5 hours, place the modified electrode in a vacuum oven ...

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Abstract

The invention discloses a high-sensitivity nanometer cobalt oxide-doped amobarbital molecular imprinting electrochemical sensor and a preparation method thereof. Amobarbital serves as a template molecule, 20(s)-O-androstane-4-alkene-17beta-acyl camptothecin serves as a functional monomer, azodiisobutyronitrile serves as an initiator, nanometer cobalt oxide serves as a doping agent, and maleated rosin ethylene glycol acrylate synthesized by taking rosin as a raw material serves as a crosslinking agent, so as to prepare a high-sensitivity nanometer cobalt oxide-doped amobarbital molecular imprinting electrochemical sensor. The analytical method is simple and practical, and the defects that the previous analytical method is complex, expensive in equipment and low in sensitivity are overcome.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a high-sensitivity nanometer cobalt oxide-doped amobarbital molecularly imprinted electrochemical sensor and a preparation method thereof. Background technique [0002] Amobarbital is a derivative of barbiturates, and its main function is as a moderate sedative to treat symptoms such as insomnia. In addition to being a drug, amobarbital is also used as a hallucinogen because of its central nervous system depressant effect, but due to long-term use of this type of drug, it can cause drug addiction problems, and can even be fatal when the drug is stopped suddenly. risk and is therefore listed as a controlled drug in most countries of the world. [0003] The methods for determining amobarbital include reversed-phase high-performance liquid chromatography gradient elution method, reversed-phase high-performance liquid chromatography-diode array method, etc. However,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/30
Inventor 余会成李浩韦贻春雷福厚谭学才陈其锋
Owner GUANGXI UNIV FOR NATITIES