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Pharmaceutical composition with myocardial ischemia resisting effect and preparation method and application thereof

An anti-myocardial ischemia and drug technology, applied in drug combinations, medical preparations containing active ingredients, applications, etc., can solve problems such as no research reports on myocardial ischemia

Active Publication Date: 2014-08-13
石任兵 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report on the purification and preparation of anti-myocardial ischemia drug substance combination from Buxin Decoction, and there is no relevant research report on the composition in the treatment of myocardial ischemia disease

Method used

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  • Pharmaceutical composition with myocardial ischemia resisting effect and preparation method and application thereof
  • Pharmaceutical composition with myocardial ischemia resisting effect and preparation method and application thereof
  • Pharmaceutical composition with myocardial ischemia resisting effect and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1: Preparation process of anti-myocardial ischemia traditional Chinese medicine drug substance combination

[0059] Ginseng 300g Poria 300g

[0060] Polygala 200g Puhuang 200g

[0061] According to the above ratio, take 1 kg of raw material drug decoction pieces, extract 3 times with 6 times the amount of 50% ethanol under reflux, and extract for 1.5 hours each time, combine the two extracts (total 20L) and concentrate under reduced pressure until the relative density is 1.15-1.20g / ml Add water to disperse the clear paste, so that the concentration of the sample solution is 0.05g / mL (in terms of the amount of raw medicinal materials), and the sample solution is adsorbed by the DM130 type macroporous adsorption resin, and the ratio of sample volume to resin volume is 0.25g : 1mL, the ratio of diameter to height of the resin column is 1:8.7, and the adsorption flow rate is 1bv / h; Elute 4 times the resin volume with ethanol, the elution flow rate is 2bv / h, collec...

Embodiment 2

[0088] Ginseng 300g Poria 300g

[0089] Polygala 200g Puhuang 200g

[0090] According to the above ratio, take 1 kg of raw material drug decoction pieces, extract 3 times with 6 times the amount of 50% ethanol under reflux, and extract for 1.5 hours each time, combine the two extracts (total 20L) and concentrate under reduced pressure until the relative density is 1.15-1.20g / ml Add water to disperse the clear paste, so that the concentration of the sample solution is 0.05g / mL (in terms of the amount of raw medicinal materials), and the sample solution is adsorbed by the DM130 type macroporous adsorption resin, and the ratio of sample volume to resin volume is 0.25g : 1mL, the ratio of diameter to height of the resin column is 1:8.7, and the adsorption flow rate is 1bv / h; Elute 4 times the resin volume with ethanol, the elution flow rate is 2bv / h, collect 40% ethanol eluate, recover the solvent, elute 3 times the resin volume with 90% ethanol, the elution flow rate is 2bv / h, c...

Embodiment 3

[0117] Ginseng 300g Poria 300g

[0118] Polygala 200g Puhuang 200g

[0119] According to the above ratio, take 1 kg of raw material drug decoction pieces, extract 3 times with 6 times the amount of 50% ethanol under reflux, and extract for 1.5 hours each time, combine the two extracts (total 20L) and concentrate under reduced pressure until the relative density is 1.15-1.20g / ml Add water to disperse the clear paste, so that the concentration of the sample solution is 0.05g / mL (in terms of the amount of raw medicinal materials), and the sample solution is adsorbed by the DM130 type macroporous adsorption resin, and the ratio of sample volume to resin volume is 0.25g : 1mL, the ratio of diameter to height of the resin column is 1:8.7, and the adsorption flow rate is 1bv / h; Elute 4 times the resin volume with ethanol, the elution flow rate is 2bv / h, collect 40% ethanol eluate, recover the solvent, elute 3 times the resin volume with 90% ethanol, the elution flow rate is 2bv / h, c...

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Abstract

The invention discloses a traditional Chinese medicine substance composition and a myocardial ischemia resisting effect thereof. The traditional Chinese medicine substance composition disclosed by the invention is obtained by extracting heart tonifying soup with ethanol and purifying with macroporous adsorption resin, and phenol and triterpenoid saponin ingredients in the heart tonifying soup are enriched; meanwhile, proved by experiments on rats with acute myocardial ischemia, the traditional Chinese medicine drug substance composition has an obvious myocardial ischemia resisting effect, and after prophylactic administration, the content of serum creatine kinase and lactate dehydrogenase in blood serum of model rats can be lowered.

Description

technical field [0001] The invention belongs to the field of drug research and development, and relates to a combination of traditional Chinese medicine substances, in particular to a combination of Chinese medicine substances with anti-myocardial ischemia effect, and a method for simultaneously preparing the combination. Background technique [0002] Myocardial ischemia refers to a pathological state in which the heart's oxygen supply is reduced due to the reduction of cardiac blood perfusion, the myocardial energy metabolism is abnormal, and the normal work of the heart cannot be supported. Coronary artery stenosis or coagulation caused by coronary atherosclerosis is the main and most common cause of myocardial ischemia, which in turn leads to myocardial ischemia and hypoxia, which causes what we often call "coronary heart disease", so coronary heart disease is The "culprit" of myocardial ischemia. There are many anti-myocardial ischemia drugs clinically, and the mechanis...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61P9/10A23L1/30A23L2/52
Inventor 石任兵王永炎王泽浩彭平姜艳艳张硕峰李钢唐雪阳
Owner 石任兵
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