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Oral composition of supplement

A composition and drug technology, which is applied in the direction of drug combination, anhydride/acid/halide active ingredients, medical preparations containing active ingredients, etc., can solve problems such as differences, increasing the complexity of patients, and the lack of uniformity in dosage

Inactive Publication Date: 2014-09-10
肖云彩 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] (2) Although there are various separate preparations clinically, there are the following disadvantages: one is to prepare each preparation separately, and the variety of types and doses of zinc preparations on the market at present increases the cumbersomeness of patients’ use
The second is that zinc supplementation and chlorine supplementation, sodium, potassium, and glucose should be supplemented in different amounts according to age, body weight, and disease characteristics. However, the instructions for the use of several zinc supplement preparations on the market are completely different, and there is no uniformity in the amount of use. In other words, it is cumbersome to calculate zinc, and the dosage of each preparation should be calculated separately, which increases the difficulty of use by clinicians and patients

Method used

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  • Oral composition of supplement
  • Oral composition of supplement
  • Oral composition of supplement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016]

[0017] Preparation process:

[0018] (1) Pulverize the above raw materials and pass through a 80-100 mesh sieve for later use.

[0019] (2) Mix the prescribed amount of zinc gluconate and the same amount of glucose evenly, and mix them 5 times in increments, and then mix evenly with the prescribed amount of sodium citrate to form a mixed powder 1.

[0020] (3) Mix the mixed powder 1 and the same amount of glucose evenly, then add the mixed powder 1 to the remaining glucose and mix evenly to form the mixed powder 2.

[0021] (4) Mix the sodium chloride and potassium chloride of the prescribed amount evenly, and it is mixed powder 3.

[0022] (5) Take about half the amount of mixed powder 3 and add mixed powder 3, and mix evenly to form mixed powder 4.

[0023] (6) Take the same amount of mixed powder 2 as mixed powder 4, add mixed powder 4, mix evenly, and become mixed powder 5.

[0024] (7) Add the remaining mixed powder 2 to mixed powder 5, and mix evenly to fo...

Embodiment 2

[0032]

[0033] Preparation process:

[0034] (1) Add hot water for injection of 80% of the prescription quantity into the thick preparation tank, add the raw materials of the prescription quantity and stir until they are all dissolved.

[0035] (2) Supplement water for injection to the prescribed amount, take a sample to measure the pH value, it should be controlled at about 4.0, and the content of each component is about 100%.

[0036] (3) After the medicinal solution is sterilized, it is filtered through a filter membrane with a diameter of 0.22 μm.

[0037] (4) Fill the filtrate with 200ml / bottle.

[0038] (5) seal. Save the finished product after passing the inspection.

[0039] Zinc gluconate in the above-mentioned prescription can be used to provide zinc sulfate, zinc citrate, zinc glycyrrhizinate, zinc acetate of equivalent zinc (Zn).

[0040] The stability test data of the sample prepared by above-mentioned embodiment 2 is as follows table 2, as seen from the t...

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Abstract

The invention provides an oral composition of a supplement. The oral composition is used when a patient suffers from dehydration, is stable, can be orally taken, comprises multiple components and can supplement needed substances to the patient suffering from dehydration. The oral composition contains sodium chloride, potassium chloride, trisodium citrate, anhydrous dextrose and a zinc salt and may be a solid preparation or a liquid preparation. An oral preparation prepared from the composition can reduce severity and duration time of a disease and lower down the incidence rate of diarrhoea in subsequent 2 to 3 months. The objective of the invention is to improve a curative effect on dehydration, enhance drug stability and medication security, reduce packaging materials and realize environmental protection.

Description

technical field [0001] The present invention relates to a composition used in oral supplements for dehydration patients, especially an oral supplement containing zinc, which increases the synergistic effect of drugs. Due to the addition of zinc, the course of treatment for dehydration of the patient is shortened. At the same time, it overcomes the disadvantages of sub-packaging of other oral supplements and reduces packaging and transportation costs. The aim is to make the composition of each ingredient and zinc into a new oral supplement that is stable and convenient for patients to take by industrial production. Background technique [0002] Diarrheal diseases are a leading cause of childhood morbidity and mortality in developing countries and an important cause of child malnutrition. An estimated 1.87 million children under the age of 5 died from diarrhea in 2003, 80 percent of whom were under the age of 2. In developing countries, children under three suffer from diar...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K33/30A61P3/02A61P3/12A61K31/7004A61K31/194A61K31/19A61K31/704
Inventor 不公告发明人
Owner 肖云彩
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