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A kind of implant prosthesis and its manufacturing method

A technology for implanting prostheses and prostheses, applied in the field of prostheses, can solve the problems of cumbersome operation steps and high processing costs, and achieve the effect of simple operation steps, non-sensitization, and obvious cytotoxicity

Inactive Publication Date: 2016-05-25
CHONGQING TRADITIONAL CHINESE MEDICINE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The plasma surface modification method is to expose the inert implant material to non-polymerizable gas plasma, and use the plasma to bombard the surface of the material to cause changes in the surface structure of the inert implant material, thereby increasing the biocompatibility of the surface. This method requires the use of a plasma generator, which is expensive to process
The surface graft copolymerization method is to graft and copolymerize hydrophilic substances to the surface of inert implant materials in the form of chemical bond cross-linking. This method can effectively improve the biocompatibility of inert implant materials, but the operation steps are relatively cumbersome.

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  • A kind of implant prosthesis and its manufacturing method
  • A kind of implant prosthesis and its manufacturing method
  • A kind of implant prosthesis and its manufacturing method

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Experimental program
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preparation example Construction

[0032] The invention also discloses a preparation method for the implanted prosthesis, comprising:

[0033] Coating a surface modifier on the surface of the inert implant material and drying it to obtain the implant prosthesis;

[0034] The surface modifiers include water, dispersants and bioceramic materials.

[0035] In the present invention, a surface modifier is first coated on the surface of the inert implant material, which refers to a biomedical material that can remain stable in a biological environment and does not or only weakly react, including but Not limited to silicone rubber, polyethylene, polyvinyl chloride, acrylic, PTFE, polyacrylamide or polyurethane. In the present invention, there is no special limitation on the source of the inert implant material, which can be purchased commercially. There is no special limitation on the shape of the inert implant material, and it can be trimmed into a desired shape according to the actual situation. In the present in...

Embodiment 1

[0045] Add 4 parts by mass of sodium carboxymethylcellulose to 94 parts by mass of pure water and stir evenly, then add 2 parts by mass of nano-sized hydroxyapatite powder and stir evenly to obtain a surface modifier.

[0046] The obtained surface modifier is sterilized, and put into a hand-held pressure spray tank after being sterilized.

[0047] The silicone rubber was trimmed into a desired shape, and then the surface modifier was sprayed on the surface of the silicone rubber, and left to dry for 10 minutes to obtain the implanted prosthesis.

[0048] Biocompatibility testing of the above implants

[0049] Sampling from the above-mentioned implanted prosthesis, the sampling specification is 0.2mm × 1cm × 1cm, with this sampling sample as the experimental group, with polylysine-coated glass slides and pure silicone rubber as the control group, the experimental group and the control group Groups were sterilized and placed in 24-well plates, with 11 samples in each group, and...

Embodiment 2

[0084] Add 1 mass part of sodium carboxymethyl cellulose to 94 mass parts of pure water and stir evenly, then add 5 mass parts of nano-sized hydroxyapatite powder and stir evenly to obtain a surface modifier.

[0085] The obtained surface modifier is sterilized, and put into a hand-held pressure spray tank after being sterilized.

[0086] The silicone rubber was trimmed into a desired shape, and then the surface modifier was sprayed on the surface of the silicone rubber, and left to dry for 15 minutes to obtain the implanted prosthesis.

[0087] A biocompatibility test was carried out on the above-mentioned implant prosthesis, and the test results showed that the above-mentioned implant prosthesis had good biocompatibility, and the growth and differentiation of cells on the surface of the above-mentioned implant prosthesis were obviously better than pure silicone rubber materials.

[0088] The biosafety test of the above-mentioned implanted prosthesis shows that the hemolysis ...

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Abstract

The invention provides implant prosthesis and a manufacturing method thereof. The implant prosthesis provided by the invention is compounded with a biological ceramic material on the surface of an inert implant material; the biological ceramic material can show good affinity with biological tissues such as cells, and therefore, the implant prosthesis has high biocompatibility, and a problem that the existing inert implant material is not compatible with the human body is solved. Meanwhile, the biological ceramic material of the implant prosthesis is compounded to the inert implant material, so that an internal structure of the inert implant material is not damaged, and therefore, decline in physical and chemical performances of the inert implant material are not caused. Experiment results indicate that the implant prosthesis prepared by the method disclosed by the invention is good in biocompatibility, free of sensitization and obvious cell toxicity.

Description

technical field [0001] The invention belongs to the field of prostheses, in particular to an implanted prosthesis and a manufacturing method thereof. Background technique [0002] Medical plastic surgery is the repair and reconstruction of congenital or acquired tissue defects and deformities of the human body through surgical operations. The most common medical plastic surgery method is to implant silicone rubber, acrylic resin, polyacrylamide and other inert implant materials into the human body as tissue substitutes to repair tissue defects or deformities caused by various reasons, so as to improve or restore their physiological functions and appearance. [0003] Due to the stable chemical properties of silicone rubber, acrylic resin, polyacrylamide and other inert implant materials, they are not easy to degrade, which makes them incompatible with human tissues after implantation, which leads to the common complication of prosthesis implantation—capsular contracture. Ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/30A61L27/34A61L27/16A61L27/18
Inventor 王科
Owner CHONGQING TRADITIONAL CHINESE MEDICINE HOSPITAL
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