Cardiovascular interventional balloon catheter and preparation method thereof

A balloon catheter and cardiovascular technology, applied in the field of medical devices, can solve problems such as inconsistent force on the radial cylinder surface, inconsistent deformation of balloon flaps, and deformation of flaps on the surface of the balloon, so as to increase the installation performance of the stent and increase the Balloon cross-sectional diameter, possible effect of reducing unloading

Active Publication Date: 2017-05-10
深圳市金瑞凯利生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the method of coating a hydrophilic coating on the balloon catheter controls the coating area to be located at the tapered position at both ends of the balloon. The ultra-long-distance hydrophilic coating significantly improves the penetrability and pushability of the catheter, making the catheter have a good Passability, the stability of the balloon during expansion, reduces the possibility of unloading, but it does not substantially improve the fixation between the balloon and the stent itself, so it can only reduce the possibility of unloading
There are balloon pre-expansion methods and reducing the size of the stent-clamped balloon to improve the mechanical crimping strength; in the balloon pre-expansion method, the balloon is pre-expanded first, and then the stent is pressed on the balloon; the balloon pre-expansion Afterwards, the progress of clamping between the stent and the balloon is enhanced. This method can minimize the unloading phenomenon during the stent delivery process. There is a large difference in deformation between the crimped area and the non-crimped area, which will cause the balloon flaps to not expand uniformly when the stent is expanded, resulting in inconsistent force on the radial cylinder surface during stent expansion, affecting the deformation uniformity of the stent. The deformation of local units of the bracket is too large, while some areas are not deformed, which directly affects the performance of the bracket
In reducing the size of the stent holding the balloon, reduce the stent clamping by about 5%. Due to the formation of a smaller compression section, the stent can be firmly fixed on the balloon, but at the same time, it will also have a certain degree of impact on the surface of the balloon. , especially when the metal stent of the rigid body is in contact with the thinner polymer surface, it may cause inconsistent deformation of the balloon flaps, and in severe cases, the balloon will rupture

Method used

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  • Cardiovascular interventional balloon catheter and preparation method thereof
  • Cardiovascular interventional balloon catheter and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] In this embodiment, a polymer balloon catheter is used as the following processing operations:

[0043] S10, the polymer balloon catheter is placed in an ultrasonic cleaning machine for cleaning, including ultrasonic cleaning with cleaning fluid for 5 minutes, then ultrasonic cleaning with distilled water for 5 minutes, and repeating the cycle cleaning process of cleaning fluid and distilled water 3 times; of course, cleaning Drying is then carried out, in this embodiment, it is sufficient to blow dry;

[0044] S20: Clamp the ultrasonically cleaned balloon catheter with a clamp, place it in a physical vapor sputtering device after clamping, and adjust and establish a vacuum environment, then pass in argon with a purity of 99.9% to make the vacuum chamber reach 25Pa; Turn on the clamp rotation drive, drive the balloon catheter held by the clamp to rotate, and control the rotation speed to 35r / min; turn on the power to start the arc to ionize the argon glow discharge into argo...

Embodiment 2

[0048] In this embodiment, a polymer balloon catheter surface is used as the following processing operations:

[0049] The cleaning, drying and vacuum environment are established as in Example 1

[0050] Clamp the ultrasonically cleaned balloon catheter with a clamp, place it in a physical vapor sputtering device after clamping, and adjust and establish a vacuum environment, then pass in argon with a purity of 99.9% to make the vacuum chamber reach 50Pa; Turn on the rotating drive of the fixture, drive the balloon catheter held by the fixture to rotate, and control the rotation speed to 35r / min; turn on the power to start the arc to ionize the argon glow discharge into argon ions, and then slowly adjust the sputtering bias to 60V, the sputtering frequency is 100KHz, so that the argon ions enter and sputter the surface of the balloon, and the sputtering time is 3min;

[0051] Similarly, clamp the ultrasonically cleaned balloon catheter with a clamp, place it in the physical vapor spu...

Embodiment 3

[0053] In this embodiment, a polymer balloon catheter is used as the following processing operations:

[0054] S10, the polymer balloon catheter is placed in an ultrasonic cleaning machine for cleaning, including ultrasonic cleaning with cleaning fluid for 5 minutes, then ultrasonic cleaning with distilled water for 5 minutes, and repeating the cycle cleaning process of cleaning fluid and distilled water twice; of course, cleaning Drying is then carried out, in this embodiment, it is sufficient to blow dry;

[0055] S20: Clamp the ultrasonically cleaned balloon catheter with a clamp, place it in a physical vapor sputtering device after clamping, and adjust and establish a vacuum environment, then pass in argon with a purity of 99.9% to make the vacuum chamber reach 40Pa; Turn on the clamp rotation drive, drive the balloon catheter held by the clamp to rotate, and control the rotation speed to 38r / min; turn on the power to start the arc to ionize the argon glow discharge into argon ...

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Abstract

The invention provides a cardiovascular intervention balloon catheter. The surface of a balloon is a rough surface, and the structure of the rough surface is of nanometer scale; the surface of the balloon is coated with a hydrophilic coating. The surface of the cardiovascular intervention balloon catheter is modified to form a plurality of nanometer scale structures, the mechanical performance of the nanometer scale structures is not changed in the deformation process of the balloon, and meanwhile the friction force on a contact surface between the bracket and the balloon is increased, so that the friction force on the contact surface between the bracket and the balloon is enhanced, and the bracket is prevented from falling off from the balloon in a conveying process.

Description

Technical field [0001] The invention belongs to the technical field of medical devices, and specifically relates to a cardiovascular intervention balloon catheter and a preparation method thereof. Background technique [0002] At present, one of the more important methods in the interventional treatment of cardiovascular diseases such as coronary heart disease is vascular stent implantation; the stent is placed in the blood vessel through interventional methods to support the stenosis and occlusion of the blood vessel and reduce the elastic retraction of the blood vessel. The purpose of maintaining smooth blood flow in the lumen, and part of the vascular stent also has the effect of preventing restenosis of the diseased blood vessel. It is an interventional treatment method with good treatment effect, fast recovery of the patient and simple operation. [0003] In the process of vascular stent implantation, a balloon catheter is often used as the delivery system for stent implantati...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61F2/958
Inventor刘恒全龚元殷俊光古湖南鞠隆艳燕珍珍
Owner深圳市金瑞凯利生物科技有限公司