Unlock instant, AI-driven research and patent intelligence for your innovation.

Topiramate slow release composition and preparation process thereof

A slow-release composition and topiramate technology, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, organic active ingredients, etc., can solve problems such as cumbersome production process, increased production cost, and narrow therapeutic window , to achieve the effect of reducing production cost, simplifying production process and facilitating quality control

Inactive Publication Date: 2014-10-01
珠海天翼医药技术开发有限公司 +1
View PDF4 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its therapeutic window is very narrow, and the fluctuation of blood drug concentration will cause many side effects. Therefore, in order to improve patient compliance and clinical administration needs, it is generally made into sustained-release preparations.
[0003] In present sustained-release preparations, such as Chinese invention patents CN1988889, CN102824302A, CN102579367A and PCT application International Publication No. WO2008 / 061226A2, the preparation process of topiramate sustained-release composition has been announced, but the above-mentioned patents are all in the preparation of drug-containing capsules. After the pills, they are coated with sustained-release materials to make film-controlled sustained-release preparations. The production process is cumbersome, which increases production costs and increases the difficulty of quality control.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Topiramate slow release composition and preparation process thereof
  • Topiramate slow release composition and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A topiramate sustained-release composition, comprising the following components in parts by weight: 650 g of topiramate, 100 g of acrylic resin, 50 g of hypromellose, 100 g of talc, and 10 g of triethyl citrate.

[0022] The preparation technology of described topiramate composition is:

[0023] (1) take by weighing 100g acrylic ester resin by formula quantity and be made into the solution that mass fraction is 10%, used solvent is 70% ethanol;

[0024] (2) Add 50g hypromellose, 100g talcum powder, and 10g triethyl citrate to the above-mentioned ethanol solution to form a coating solution;

[0025] (3) take by weighing 650g topiramate and put in the powder coating machine, carry out powder coating with above-mentioned coating solution;

[0026] (4) Drying at 30° C. for 8 hours after coating is completed to obtain the topiramate sustained-release composition.

Embodiment 2

[0028] A topiramate sustained-release composition, comprising the following components in parts by weight: 300 g of ethyl cellulose, 200 g of hydroxypolyethylene glycol, 200 g of magnesium stearate, 30 g of dibutyl sebacate, and 850 g of topiramate.

[0029] The preparation technology of described topiramate composition is:

[0030] (1) taking by weighing 300g ethylcellulose is made into the solution that mass fraction is 30%, and used solvent is the ethanol of 90%;

[0031] (2) Add 200g polyethylene glycol, 200g magnesium stearate, and 30g dibutyl sebacate to the above ethanol solution to form a coating solution;

[0032] (3) take by weighing 850g topiramate and put in the powder coating machine, carry out powder coating with above-mentioned coating solution;

[0033] (4) Drying at 50° C. for 14 hours after coating is completed to obtain the topiramate sustained-release composition.

Embodiment 3

[0035] A topiramate sustained-release composition, comprising the following components in parts by weight: 200 g of ethyl cellulose, 130 g of oxypovidone, 150 g of silicon dioxide, 20 g of triethyl citrate, and 750 g of topiramate.

[0036] The preparation technology of described topiramate composition is:

[0037] (1) taking by weighing 200g propylene ester resin is made into the solution that mass fraction is 20%, and used solvent is the ethanol of 80%;

[0038] (2) Add 130g povidone, 150g silicon dioxide and 20g triethyl citrate to the above ethanol solution to form a coating solution;

[0039] (3) Take by weighing 750g bulk drug and put in the powder coating machine, carry out powder coating with above-mentioned coating solution;

[0040] (4) Drying at 40° C. for 11 hours after coating is completed, to obtain the topiramate sustained-release composition.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a topiramate slow release composition, comprising the following components in parts by mass: 65-85 parts of raw material medicine, 10-30 parts of slow release material, 5-20 parts of porogenic agent, 10-20 parts of lubricant and 1-3 parts of plasticizer. The invention further discloses a process of preparing the topiramate slow release composition. A powder coating process is adopted in the preparation method to cover the raw material medicine slow release material at one time to prepare the slow release composition. The slow release composition can be made into capsules, tablets, granules, suspensions and emulsions. The slow release composition and the preparation process thereof provided in the invention are used for simplifying the production process and reducing the production cost.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to a topiramate sustained-release composition and a preparation process thereof. Background technique [0002] Topiramate is a new broad-spectrum antiepileptic drug with multiple antiepileptic mechanisms of action. All have obvious curative effect. However, its therapeutic window is very narrow, and the fluctuation of blood drug concentration will cause many side effects. Therefore, in order to improve patient compliance and clinical administration needs, it is generally made into a sustained-release preparation. [0003] In present sustained-release preparations, such as Chinese invention patents CN1988889, CN102824302A, CN102579367A and PCT application International Publication No. WO2008 / 061226A2, the preparation process of topiramate sustained-release composition has been announced, but the above-mentioned patents are all in the preparation of drug-containing capsules. Afte...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/7048A61K47/38A61K47/32A61K47/34
Inventor 张晓明麦耀权
Owner 珠海天翼医药技术开发有限公司