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Probiotics dispersible tablets and preparation method thereof

A technology for probiotics and dispersible tablets, which is applied in the field of health food and achieves the effects of simple and feasible preparation method, easy portability and various eating methods.

Inactive Publication Date: 2014-10-08
任发政
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the existing technologies and patents, the application of dispersible tablets is mainly focused on drugs and some natural products, and the process, applicability, and microbial activity of probiotic dispersible tablets need to be further improved.

Method used

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  • Probiotics dispersible tablets and preparation method thereof
  • Probiotics dispersible tablets and preparation method thereof
  • Probiotics dispersible tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A kind of probiotic dispersible tablet, the raw material of described dispersible tablet comprises probiotic bacterium powder, CaHPO 4 , microcrystalline cellulose, sodium carboxymethyl starch, cross-linked polyvinylpyrrolidone, the ratio of parts by weight of each raw material is:

[0036]

[0037] Further, the raw materials of the dispersible tablet also include sweeteners, flavoring agents and essences, and the ratio of parts by weight of each raw material is:

[0038] Sweetener 0.1-5

[0039] Flavoring agent 0.1-4

[0040] Fragrance 0.1-2.

[0041] Further, the raw material of the dispersible tablet also includes a protective agent, and the ratio of parts by weight of the protective agent is:

[0042] Protectant 0.2-5.

[0043] Further, the protecting agent is composed of glycerin and skim milk powder, and the weight-number ratio of the glycerin and skim milk powder is:

[0044] Glycerin 0.1-3

[0045] Skim milk powder 0.1-2.

[0046] Further, the probioti...

Embodiment 2

[0056] This example is an optimization scheme based on Example 1, and provides a probiotic dispersible tablet and a preparation process thereof. For the parts in this embodiment that are the same as those in Embodiment 1, please refer to the content disclosed in Embodiment 1 for understanding, and the content disclosed in Embodiment 1 should also be regarded as the content of this embodiment, and will not be described repeatedly here.

[0057] The raw material of the dispersible tablet described in the present embodiment comprises probiotic bacterium powder, CaHPO 4 , microcrystalline cellulose, sodium carboxymethyl starch, cross-linked polyvinylpyrrolidone, the ratio of parts by weight of each raw material is:

[0058]

[0059]

[0060] The probiotics are selected from the mixture of Lactobacillus salivarius and Lactobacillus casei respectively preparing bacteria powder.

[0061] Total number of colonies

[0062]

Embodiment 3

[0064] This example is an optimization scheme based on Example 1, and provides a probiotic dispersible tablet and a preparation process thereof. For the parts in this embodiment that are the same as those in Embodiment 1, please refer to the content disclosed in Embodiment 1 for understanding, and the content disclosed in Embodiment 1 should also be regarded as the content of this embodiment, and will not be described repeatedly here.

[0065] The weight and number ratio of each raw material of dispersible tablet described in the present embodiment is:

[0066]

[0067] The essence is orange oil essence; the probiotic is selected from the mixture of Bifidobacterium, Lactobacillus plantarum and Bacillus bulgaricus powder.

[0068] Total number of colonies

[0069]

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Abstract

The invention discloses probiotics dispersible tablets and a preparation method thereof. The probiotics dispersible tablets comprise probiotics powder, starch 1500, lactose, hard magnesium sulfate, sodium carboxymethyl starch and crospolyvinylpyrrolidone. The invention also provides a preparation method of the dispersible tablets. The dispersible tablets are granulated by a wet method, a disintegrating agent and a tabletting way are used, and an appropriate process scheme can be selected for different microorganisms, different processing ways and different application ways. The probiotics dispersible tablets can achieve an effect of disintegrating within three minutes and can be directly drunk or directly eaten in a chewing manner.

Description

technical field [0001] The invention belongs to the field of health food, in particular to a probiotic dispersible tablet and a preparation method thereof. Background technique [0002] There is a special type of dosage form in tablets——dispersible tablets, which refer to tablets that can be completely disintegrated in water at 19°C-21°C within 3 minutes to form a uniform viscous suspension. It is an immediate-release solid dosage form that has been studied more this year. It has the advantages of both tablets and liquid preparations, and overcomes the shortcomings of both. Compared with ordinary tablets, dispersible tablets have the characteristics of good dispersion state, disintegration time period, rapid drug dissolution, fast absorption, high bioavailability, less adverse reactions, and convenient administration. They can be swallowed, chewed, or dispersed in water. It is especially suitable for the elderly and those who have difficulty swallowing. Compared with anoth...

Claims

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Application Information

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IPC IPC(8): A23L1/29A23L33/00
CPCA23L33/00A23P10/28A23V2002/00
Inventor 葛绍阳叶艳梅桑跃赵亮张明张昊郭慧媛刘松玲金君华
Owner 任发政
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