Method for preparing N-tert-butyloxycarbonyl-3-hydroxy-1-adamantyl-d-glycine

A technology of adamantylglycine and tert-butoxycarbonyl, which is applied in the field of preparation of N-tert-butoxycarbonyl-3-hydroxy-1-adamantylglycine, can solve the problems of difficult preparation and preservation of biological enzymes, and achieves Solve the effect of difficult preparation and preservation, lower production cost and high yield
CN104098487AInactive Publication Date: 2014-10-15天津民祥生物医药股份有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
天津民祥生物医药股份有限公司
Publication Date
2014-10-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for preparing N-tert-butyloxycarbonyl-3-hydroxy-1-adamantyl-d-glycine. A chemical synthesis method is adopted to replace preparation of a saxagliptin intermediate in the prior art, a chiral inducer participates in a reaction to perform chiral synthesis, and the preparation method is simple and convenient to operate and high in yield, reduces production cost of the intermediate and solves the technical problem of difficulty in biological enzyme preparation and storage caused by the fact that resolution needs to be performed through biological enzymes in the prior art.
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Description

technical field

[0001] The invention relates to the technical field of pharmacy, in particular to a preparation method of N-tert-butoxycarbonyl-3-hydroxyl-1-adamantylglycine. Background technique

[0002] Saxagliptin, an incretin-based hypoglycemic drug jointly developed by two global pharmaceutical companies, Bristol-Myers Squibb and AstraZeneca, has been launched in many countries including the United States, India and the European Union. 46 countries within the country have obtained marketing approval. Saxagliptin, a potent dipeptidyl peptidase-4 inhibitor, is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes.

[0003] In May 2011, it was officially approved by SFDA in China. The drug can be used as a monotherapy, or in combination with metformin on the basis of poor control of metformin. Clinical studies have confirmed that saxagliptin has the advantages of outstanding curative effect and long-lasting effect. [0...

Claims

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