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A preparation process and tablet compression technology, applied in the field of medicine, can solve the problems of high safety and inability to meet the cost of patients
Inactive Publication Date: 2014-11-05
TIANJIN PACIFIC PHARMA
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Weight loss and lipid-lowering have become one of the ways to lower blood lipids. Many chemical lipid-lowering drugs have side effects. They fundamentally regulate physical fitness and are effective in reducing
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Embodiment 1
[0019] 1. The crushing of materials, Panax notoginseng powder is crushed into fine powder, passed through 80-mesh sieve, pine pollen is directly passed through 80-mesh sieve, and the raw materials of Polygonum multiflorum, Pueraria lobata, Cuscuta, Lycium barbarum, Salvia miltiorrhiza, Rhubarb, Alisma, and Yinchen Bawei raw materials are crushed into The coarse powder is passed through a 24-mesh sieve.
[0020] 2 Alcohol extraction, the coarse powder sieved in the previous step is reflux extracted with 3 times the amount of 70% ethanol, extracted twice, each time for 3 hours, filtered, the combined filtrate reclaims ethanol and concentrates to a relative density of 1.1g / ml (80°C) extract. 3. Decoct in water, decoct the remaining medicinal dregs after alcohol extraction, the amount of water is also 3 times the volume of the medicinal dregs, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.3g / ml (90°C ) thick paste. ...
Embodiment 2
[0024] 1. The crushing of materials, Panax notoginseng powder is crushed into fine powder, passed through 80-mesh sieve, pine pollen is directly passed through 80-mesh sieve, and the raw materials of Polygonum multiflorum, Pueraria lobata, Cuscuta, Lycium barbarum, Salvia miltiorrhiza, Rhubarb, Alisma, and Yinchen Bawei raw materials are crushed into The coarse powder is passed through a 50-mesh sieve.
[0025] 2 Alcohol extraction, the coarse powder sieved in the previous step is reflux extracted with 3 times the amount of 70% ethanol, extracted twice, each time for 3 hours, filtered, the combined filtrate reclaims ethanol and concentrates to a relative density of 1.08g / ml (80°C) extract. 3 Decoct in water, decoct the remaining medicinal residues after alcohol extraction with water, the amount of water is also 3 times the volume of the medicinal residues, each time for 2 hours, combine the decoctions, filter, and concentrate the filtrate to a relative density of 1.28g / ml (90...
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Abstract
The invention provides a preparation process of a lipid-lowering tablet. The preparation process comprises the steps of crushing raw medicines, alcohol extracting, decocting with water, carrying out mixing granulation and tabletting, wherein during material crushing, except a pine pollen powder, panax notoginseng is crushed into a fine powder, other eight raw medicines such as fallopia multiflora and the like are crushed into coarse powders; during alcohol extracting, reflux extraction is carried out on the coarse powders obtained in the previous step by 70 percent ethanol the amount of which is 3 times that of coarse powders; during decocting with water, medicine residues remained after alcohol extracting are decocted with water, and the water quantity is also 3 times the volume of medicine residues; during mixing granulation, thick paste after concentrating by alcohol extracting and thick paste after concentrating by decoction with water are combined and uniformly mixed, spray drying is carried out on the mixture, a dry powder is sieved by an 80-mesh sieve and then is mixed with the pine pollen powder and the panax notoginseng powder which are sieved by an 80-mesh sieve respectively, and granulation is carried out with 85 percent ethanol as an adhesive; and tabletting and coating are carried out, magnesium stearate is sieved by a 40-mesh sieve and is mixed with particles prepared in the last step, granulation, drying and tabletting are carried out, and a film coating is coated on a tablet by a prepared coating liquid to obtain the lipid-lowering tablet.
Description
[0001] technical field [0002] The invention belongs to the field of medicine, and in particular relates to a preparation process of Jiangzhi tablets. Background technique [0003] Obesity and hyperlipidemia are common diseases and frequently-occurring diseases. With the improvement of people's living standards, their incidence rates are increasing year by year, becoming the main diseases that threaten human health. Weight loss and lipid-lowering have become one of the ways to lower blood lipids. Many chemical lipid-lowering drugs have side effects. They fundamentally regulate physical fitness and are effective in reducing blood lipids. Traditional Chinese medicine is more and more popular, but conventional preparation methods or Decoction or more expensive granules cannot meet the needs of patients with low cost and high safety. Contents of the invention [0004] The purpose of the present invention is to provide a preparation process of lipid-lowering tablets which is...
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