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Veterinary compound tilmicosin injection and preparation method thereof

A technology of tilmicosin and injection, which is applied to the preparation of veterinary compound tilmicosin injection and the field of veterinary compound tilmicosin injection, which can solve the problem that the curative effect cannot meet the use requirements and the bioavailability is not high , Incomplete animal absorption and other problems, to achieve the effect of improving bioavailability, long acting time, and convenient operation

Inactive Publication Date: 2014-11-26
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the tilmicosin injection currently on the market has unstable performance, incomplete absorption by animals, low bioavailability, short action time of the active ingredients of the drug, and its curative effect cannot meet the requirements for use.

Method used

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  • Veterinary compound tilmicosin injection and preparation method thereof
  • Veterinary compound tilmicosin injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The veterinary compound tilmicosin injection of the present embodiment contains tilmicosin 20g, florfenicol 5g, sodium formaldehyde sulfoxylate 0.5g, sodium benzoate 3.5g in every 100ml injection, and the balance is injection use water.

[0020] A kind of preparation method of above-mentioned veterinary tilmicosin injection, comprises the following steps:

[0021] 1) Take 30ml of water for injection, add 0.5g of sodium formaldehyde sulfoxylate and 3.5g of sodium benzoate, stir and dissolve to obtain solution A;

[0022] 2) Add 20 g of tilmicosin and 5 g of florfenicol to solution A obtained in step 1), stir and dissolve to obtain solution B;

[0023] 3) Dilute solution B to 100ml with water for injection, mix well, filter through a 0.45μm filter membrane, pack into ampoules, and steam sterilize at 115°C for 20min to obtain the product.

Embodiment 2

[0025] The veterinary compound tilmicosin injection of the present embodiment contains tilmicosin 25g, florfenicol 8g, sodium bisulfite 0.7g, salicylic acid 5.0g in every 100ml injection, and the balance is water for injection .

[0026] A kind of preparation method of above-mentioned veterinary tilmicosin injection, comprises the following steps:

[0027] 1) Take 30ml of water for injection, add 0.7g of sodium bisulfite and 5.0g of salicylic acid, stir and dissolve to obtain solution A;

[0028] 2) Add 25g of tilmicosin and 8g of florfenicol to solution A obtained in step 1), stir and dissolve to obtain solution B;

[0029] 3) Dilute solution B to 100ml with water for injection, mix well, filter through a 0.45μm filter membrane, pack into ampoules, and steam sterilize at 115°C for 20min to obtain the product.

Embodiment 3

[0031] The veterinary compound tilmicosin injection of the present embodiment contains tilmicosin 30g, florfenicol 10g, disodium edetate 1.0g, sodium salicylate 8.0g in every 100ml injection. The amount is water for injection.

[0032] A kind of preparation method of above-mentioned veterinary tilmicosin injection, comprises the following steps:

[0033] 1) Take 30ml of water for injection, add 1.0g of disodium edetate and 8.0g of sodium salicylate, stir and dissolve to obtain solution A;

[0034] 2) Add 30 g of tilmicosin and 10 g of florfenicol to solution A obtained in step 1), stir and dissolve to obtain solution B;

[0035] 3) Dilute solution B to 100ml with water for injection, mix well, filter through a 0.45μm filter membrane, pack into ampoules, and steam sterilize at 115°C for 20min to obtain the product.

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Abstract

The invention discloses a veterinary compound tilmicosin injection and a preparation method thereof. 100ml of the veterinary compound tilmicosin injection comprises 15-30g of tilmicosin, 4-10g of florfenicol, 0.5-1.0g of an anti-oxidant, 3.3-8.0g of a cosolvent and the balance injection water. The veterinary compound tilmicosin injection having stable performances is prepared from tilmicosin and florfenicol as main raw materials and the anti-oxidant and the cosolvent as auxiliary materials. After intramuscular injection, the veterinary compound tilmicosin injection can be easily absorbed by animals and even completely absorbed, improves bioavailability, has long drug active ingredient action time, can be used for clinical treatment on livestock and poultry respiratory tract system disease caused by a plurality of pathogenic bacteria, has good curative effects and is convenient for use. The preparation method of the veterinary compound tilmicosin injection has simple processes, is convenient for operation and is suitable for large-scale industrial production.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, relates to a compound tilmicosin injection for animals, and also relates to a preparation method of the compound tilmicosin injection for animals. Background technique [0002] Tilmicosin is a macrolide antibiotic semi-synthesized from tylosin. It is a special antibiotic for livestock and poultry, and its phosphate is used for medicine. Tilmicosin was successfully developed in the 1980s, and its preparations include tilmicosin soluble powder, tilmicosin premix (20%), tilmicosin injection, etc. Tilmicosin has inhibitory effects on Gram-positive bacteria, some Gram-negative bacteria, mycoplasma, spirochetes, etc.; it has stronger antibacterial activity than tylosin on Actinomyces pleuropneumoniae and Pasteurella. Clinically, it is mainly used to prevent and treat livestock pneumonia (caused by Actinobacillus pleuropneumoniae, Pasteurella, Mycoplasma, etc.), avian mycoplasma disease and...

Claims

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Application Information

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IPC IPC(8): A61K31/706A61K9/08A61P31/04A61P11/00A61K31/165
Inventor 王丽景李建正陈建晖
Owner ZHENGZHOU HOUYI PHARMA