Composite medical dressing and preparation method thereof

A medical and composite technology, which is applied in the field of composite medical dressings and its preparation, can solve the problems of poor biocompatibility, unfavorable, and relieve wound pain

Active Publication Date: 2014-11-26
BEIJING DINGHAN HENGHAI BIOLOGICAL TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The prior art medical dressings have poor biocompatibility with the skin, which is not conducive to reducing wound pain and promoting wound healing

Method used

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  • Composite medical dressing and preparation method thereof
  • Composite medical dressing and preparation method thereof
  • Composite medical dressing and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0073] In the second aspect, the embodiment of the present invention provides a method for preparing a composite medical dressing, with figure 1 A flowchart of the preparation method. as attached figure 1 As shown, the method includes:

[0074] Step 101, purifying the bacterial cellulose membrane until the content of bacterial endotoxin in the bacterial cellulose membrane is less than 0.25 EU / ml to obtain a purified bacterial cellulose membrane;

[0075] Step 102, preparing an organosilicon quaternary ammonium salt solution with a concentration of 0.0025-0.04 g / ml;

[0076] Step 103, compounding the purified bacterial cellulose membrane with the organosilicon quaternary ammonium salt solution to obtain a composite medical dressing;

[0077] Step 101 and step 102 are not limited in sequence.

[0078] The above-mentioned "step 101 and step 102 have no order restriction" is given as an example as follows: step 101 comes first, then step 102; Perform step 101 to completion; p...

Embodiment 1

[0110] Step a, use pure water to wash the bacterial cellulose membrane until the pH of the bacterial cellulose membrane is 5, put the bacterial cellulose membrane washed by pure water into a sodium hydroxide solution with a concentration of 0.05mol / L, and heat up to 60 -80°C, after stirring for 10 hours, the bacterial cellulose membrane was taken out, washed with pure water until the pH of the bacterial cellulose membrane was 5-6 and the content of bacterial endotoxin in the bacterial cellulose membrane was 0.25EU / ml, obtained Purified bacterial cellulose membrane.

[0111] Wherein, the bacterial cellulose membrane is a bacterial cellulose membrane fermented by at least one bacterium selected from the genus Achromobacter, and has a three-dimensional porous network structure.

[0112] Step b. Add the organosilicon quaternary ammonium salt into pure water, stir until completely dissolved, continue to add pure water, so that the concentration of the organosilicon quaternary ammon...

Embodiment 2

[0116]Wash the bacterial cellulose membrane with pure water until the pH of the bacterial cellulose membrane is 7.5, put the bacterial cellulose membrane washed with pure water into a potassium hydroxide solution with a concentration of 0.4mol / L, heat up to 85°C, and stir After 24 hours, the bacterial cellulose membrane was taken out and washed with pure water until the pH of the bacterial cellulose membrane was 4 and the bacterial endotoxin content in the bacterial cellulose membrane was less than 0.125EU / ml to obtain a purified bacterial cellulose membrane .

[0117] Wherein, the bacterial cellulose membrane is a bacterial cellulose membrane fermented by at least one bacterium selected from Rhizobium, Pseudomonas, Aerobacter, Azotobacter, and Sarcina, and has a three-dimensional porous network structure.

[0118] Step b. Add the organosilicon quaternary ammonium salt into pure water, stir until completely dissolved, continue to add pure water, so that the concentration of t...

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Abstract

The invention discloses a composite medical dressing and a preparation method thereof, and belongs to the technical field of medical dressings. The composite medical dressing obtained by compounding an organic quaternary ammonium salt to a bacterial cellulose membrane has good biocompatibility, benefits the reduction of pains of wounds, promotes healing of the wounds, and also has good sterilization and bacteriostasis functions. The invention also discloses the preparation method of the composite medical dressing. The method is characterized in that an organic quaternary ammonium salt solution and the purified bacterial cellulose membrane are compounded to make an organosilicon quaternary ammonium salt compounded to the bacterial cellulose membrane in order to prepare the composite medical dressing with good biocompatibility and good sterilization and bacteriostasis functions. The method has the advantages of simplicity, easy operation, and convenience for large scale application.

Description

technical field [0001] The invention relates to the field of medical dressings, in particular to a composite medical dressing and a preparation method thereof. Background technique [0002] Medical dressing is a medical product used to cover burns, wounds, ulcers and other wounds. Its function is to control the evaporation of wound exudate, provide a moist environment conducive to wound healing, and prevent the wound from being infected by bacteria. With the advancement of medical science, the demand for medical dressings is more and more extensive, and it is necessary to provide a medical dressing and a preparation method thereof. [0003] In the prior art, after the degreasing gauze is alkalized, it is put into the organic silicon quaternary ammonium salt solution, reacted in a constant temperature water bath at 25-70°C for 0.5-7h, and after being washed with an organic solution and dried, the quaternized ammonium Medical dressing. [0004] The inventor finds that the pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/28A61L15/20
Inventor 费浩刘辉石凌锋闫瑞国张香春
Owner BEIJING DINGHAN HENGHAI BIOLOGICAL TECH DEV
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