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A kind of composite medical dressing and preparation method thereof

A medical and bacterial cellulose film technology, applied in the field of composite medical dressings and preparation thereof, can solve the problems of reducing wound pain, poor biocompatibility, disadvantages, etc., and achieve the effects of reducing wound pain, simple method and good sterilization

Active Publication Date: 2016-06-15
BEIJING DINGHAN HENGHAI BIOLOGICAL TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The prior art medical dressings have poor biocompatibility with the skin, which is not conducive to reducing wound pain and promoting wound healing

Method used

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  • A kind of composite medical dressing and preparation method thereof
  • A kind of composite medical dressing and preparation method thereof
  • A kind of composite medical dressing and preparation method thereof

Examples

Experimental program
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preparation example Construction

[0072] In the second aspect, the embodiment of the present invention provides a method for preparing a composite medical dressing, with figure 1 A flowchart of the preparation method. as attached figure 1 As shown, the method includes:

[0073] Step 101, purifying the bacterial cellulose membrane until the content of bacterial endotoxin in the bacterial cellulose membrane is less than 0.25 EU / ml to obtain a purified bacterial cellulose membrane;

[0074] Step 102, preparing an organosilicon quaternary ammonium salt solution with a concentration of 0.0025-0.04 g / ml;

[0075] Step 103, compounding the purified bacterial cellulose membrane with the organosilicon quaternary ammonium salt solution to obtain a composite medical dressing;

[0076] Step 101 and step 102 are not limited in sequence.

[0077] The above-mentioned "step 101 and step 102 have no order restriction" is given as an example as follows: step 101 comes first, then step 102; Perform step 101 to completion; p...

Embodiment 1

[0109] Step a, use pure water to wash the bacterial cellulose membrane until the pH of the bacterial cellulose membrane is 5, put the bacterial cellulose membrane washed by pure water into a sodium hydroxide solution with a concentration of 0.05mol / L, and heat up to 60 -80°C, after stirring for 10 hours, the bacterial cellulose membrane was taken out, washed with pure water until the pH of the bacterial cellulose membrane was 5-6 and the content of bacterial endotoxin in the bacterial cellulose membrane was 0.25EU / ml, obtained Purified bacterial cellulose membrane.

[0110] Wherein, the bacterial cellulose membrane is a bacterial cellulose membrane fermented by at least one bacterium selected from the genus Achromobacter, and has a three-dimensional porous network structure.

[0111] Step b. Add the organosilicon quaternary ammonium salt into pure water, stir until completely dissolved, continue to add pure water, so that the concentration of the organosilicon quaternary ammon...

Embodiment 2

[0115] Wash the bacterial cellulose membrane with pure water until the pH of the bacterial cellulose membrane is 7.5, put the bacterial cellulose membrane washed with pure water into a potassium hydroxide solution with a concentration of 0.4mol / L, heat up to 85°C, and stir After 24 hours, the bacterial cellulose membrane was taken out and washed with pure water until the pH of the bacterial cellulose membrane was 4 and the bacterial endotoxin content in the bacterial cellulose membrane was less than 0.125EU / ml to obtain a purified bacterial cellulose membrane .

[0116]Wherein, the bacterial cellulose membrane is a bacterial cellulose membrane fermented by at least one bacterium selected from Rhizobium, Pseudomonas, Aerobacter, Azotobacter, and Sarcina, and has a three-dimensional porous network structure.

[0117] Step b. Add the organosilicon quaternary ammonium salt into pure water, stir until completely dissolved, continue to add pure water, so that the concentration of t...

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Abstract

The invention discloses a composite medical dressing and a preparation method thereof, belonging to the technical field of medical dressings. The composite medical dressing prepared by compounding the organic quaternary ammonium salt on the bacterial cellulose film not only has good biocompatibility, is beneficial to relieve wound pain and promote wound healing, but also has good bactericidal and bacteriostatic functions . The invention also discloses a preparation method of a composite medical dressing, comprising: compounding the organic quaternary ammonium salt solution with the negatively purified bacterial cellulose membrane, and compounding the organic silicon quaternary ammonium salt on the bacterial cellulose membrane to prepare the Composite medical dressing with good biocompatibility and good bactericidal and antibacterial functions. The method is simple, easy to operate and convenient for large-scale application.

Description

technical field [0001] The invention relates to the field of medical dressings, in particular to a composite medical dressing and a preparation method thereof. Background technique [0002] Medical dressing is a medical product used to cover burns, wounds, ulcers and other wounds. Its function is to control the evaporation of wound exudate, provide a moist environment conducive to wound healing, and prevent the wound from being infected by bacteria. With the advancement of medical science, the demand for medical dressings is more and more extensive, and it is necessary to provide a medical dressing and a preparation method thereof. [0003] In the prior art, after the degreasing gauze is alkalized, it is put into the organic silicon quaternary ammonium salt solution, reacted in a constant temperature water bath at 25-70°C for 0.5-7h, and after being washed with an organic solution and dried, the quaternized ammonium Medical dressing. [0004] The inventor finds that the pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/42A61L15/28A61L15/20
Inventor 费浩刘辉石凌锋闫瑞国张香春
Owner BEIJING DINGHAN HENGHAI BIOLOGICAL TECH DEV
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