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Subcutaneous injection administration system based on Brij97 liquid crystal and preparation method of subcutaneous injection administration system based on Brij97 liquid crystal

A technology for subcutaneous injection and drug delivery system, which is applied to pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. To achieve the effect of convenient and easy process control, increase patient compliance, and increase stability

Inactive Publication Date: 2014-12-03
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The composition of the oil phase makes the composition of the precursor formulation complex, which is not conducive to the formulation screening work. Not only that, the complexity of the liquid crystal composition will increase the difficulty of controlling the structure after the water absorption phase transition

Method used

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  • Subcutaneous injection administration system based on Brij97 liquid crystal and preparation method of subcutaneous injection administration system based on Brij97 liquid crystal
  • Subcutaneous injection administration system based on Brij97 liquid crystal and preparation method of subcutaneous injection administration system based on Brij97 liquid crystal
  • Subcutaneous injection administration system based on Brij97 liquid crystal and preparation method of subcutaneous injection administration system based on Brij97 liquid crystal

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Weigh 200 mg Brij97, 50 mg IPM, 50 mg water, and 1.5 mg insulin (the amount of IPM accounts for about 20% of the total amount of Brij97 and IPM). Put the weighed Brij97 and IPM into the same vial, heat and melt in a water bath at 40°C to become liquid, and vortex to mix. Prepare insulin solution. Add the insulin solution to Brij97 and IPM, vortex to mix, and stand at room temperature to remove air bubbles.

[0035] For the 24h in vitro release of the Brij97 liquid crystal subcutaneous injection drug delivery system prepared in this example, see figure 1 .

[0036] The 72h in vitro release of the Brij97 liquid crystal subcutaneous injection drug delivery system prepared in this example is shown in figure 2 .

[0037] Polarizing micrographs (25°C, magnification 200) of the subcutaneous injection drug delivery system of Brij97 liquid crystal prepared in this example after contacting water for 0.5h, see image 3 . image 3 Appears as a lamellar phase.

[0038] Polar...

Embodiment 2

[0042]Weigh 210mg Brij97, 90mg water, 1.5mg insulin. Put the weighed Brij97 and IPM into the same vial, heat and melt in a water bath at 40°C to become liquid, and vortex to mix. Prepare insulin solution. Add the insulin solution to Brij97 and IPM, vortex to mix, and stand at room temperature to remove air bubbles.

[0043] For the 24h in vitro release rate of the Brij97 liquid crystal subcutaneous injection drug delivery system prepared in this example, see figure 1 .

[0044] For the viscosity of the subcutaneous injection drug delivery system of the Brij97 liquid crystal prepared in this example, see Image 6 .

Embodiment 3

[0046] Weigh 235 mg Brij97, 25 mg IPM, 40 mg water, and 1.5 mg insulin (the amount of IPM accounts for about 10% of the total amount of Brij97 and IPM). Put the weighed Brij97 and IPM into the same vial, heat and melt in a water bath at 40°C to become liquid, and vortex to mix. Prepare insulin solution. Add the insulin solution to Brij97 and IPM, vortex to mix, and stand at room temperature to remove air bubbles.

[0047] For the 24h in vitro release rate of the Brij97 liquid crystal subcutaneous injection drug delivery system prepared in this example, see figure 1 .

[0048] For the viscosity of the subcutaneous injection drug delivery system of the Brij97 liquid crystal prepared in this example, see Image 6 .

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Abstract

The invention discloses a subcutaneous injection administration system based on Brij97 liquid crystal and a preparation method of the subcutaneous injection administration system based on Brij97 liquid crystal. The preparation of the administration system comprises the following components in percentage by weight: 0.05-5 percent of medicines, 60-85 percent of Brij97, 0-25 percent of an adding material and 10-40 percent of water, wherein the content ratio of Brij97 to water is more than 7:3. Compared with a common oleophylic liquid-crystal vector material, the administration system has the advantages of excellent long-acting sustained release performance, good bio-compatibility, small toxic and side effect and small stimulation due to addition of the hydrophilic liquid crystal material Brij97, and is applicable to subcutaneous injection administration of protein polypeptide medicines.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a subcutaneous injection drug delivery system based on Brij97 liquid crystal and a preparation method thereof. Background technique [0002] The development of genomics and proteomics has promoted the development of protein and peptide drugs. Protein and peptide drugs such as peptides, proteins, hormones, vaccines and monoclonal antibodies play an important therapeutic and preventive role in clinical practice. The drug delivery system of protein and polypeptide drugs has become a research hotspot in modern pharmacy. Such drugs have the advantages of small dosage, strong pertinence, and high pharmacological activity, but have the disadvantages of generally short biological half-life and poor physical stability. At present, the main dosage forms of protein polypeptide drugs are injections (solution type and suspension type injections) and freeze-dried powder...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/34A61K47/14A61K47/12A61K38/28
Inventor 蒋曙光袁惠卿马爱明
Owner CHINA PHARM UNIV
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