Preparation method for triamcinolone acetonide acetate ultradeformable nanometer lipid vesicle spraying agent and application to target hypertrophic scars
A technology of triamcinolone acetonide acetate and nano-lipids, which is applied in aerosol delivery, medical preparations containing active ingredients, and pharmaceutical formulas. There are no reports on the preparation of vesicle sprays, etc., and the therapeutic effect is remarkable and the effect is long-lasting.
Inactive Publication Date: 2014-12-03
SHANGHAI SEVENTH PEOPLES HOSPITAL
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Abstract
The invention discloses a preparation method for a triamcinolone acetonide acetate ultradeformable nanometer lipid vesicle spraying agent and application to target hypertrophic scars. The triamcinolone acetonide acetate ultradeformable nanometer lipid vesicle spraying agent is composed of the following compositions in percent by weight: 0.05%- 0.5% of triamcinolone acetonide acetate, 0.5%- 10% of phosphatide, and 0.2%- 50% of a softener. The prepared triamcinolone acetonide acetate ultradeformable nanometer lipid vesicle spraying agent has the average particle size of 50-500 nm. By optimizing the above ratio, the medicine can be relatively highly concentrated at a scar skin nidus area, and the composition ratio comprises, in percent by weight, 0.1% of triamcinolone acetonide, 4% of phosphatide, and 0.77% of sodium cholate. The prepared triamcinolone acetonide acetate ultradeformable nanometer lipid vesicle spraying agent solves many problems caused by multi-point injection in scar and triamcinolone acetonide external application, and is substantial in the hypertrophic-scar targeting effect.
Application Domain
Organic active ingredientsAerosol delivery +1
Technology Topic
DrugChemistry +6
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PUM
Property | Measurement | Unit |
The average particle size | 50.0 ~ 500.0 | nm |
The average particle size | 100.0 ~ 200.0 | nm |
Particle size | 100.0 ~ 200.0 | nm |
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