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Formula and preparation method of florfenicol powder

A technology of florfenicol and ammonium chloride, applied in powder delivery, chlorine active ingredients, antibacterial drugs, etc., can solve the problems of low water solubility of florfenicol, inconvenient clinical use, affecting drug efficacy, etc., and achieve curative effect Significant, easy-to-discharge, water-increasing effect

Inactive Publication Date: 2014-12-03
PIZHOU ZHENGKANG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, in the current use of florfenicol powder, due to the low water solubility of florfenicol, the efficacy of the drug is affected, and clinical use is inconvenient. Therefore, improving the solubility of florfenicol is a problem that needs to be solved urgently in clinical use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Pass florfenicol, ammonium chloride and anhydrous glucose through 80-mesh sieve respectively, and set aside.

[0022] (2) Weigh 2kg of sieved florfenicol and 5kg of ammonium chloride, and fully mix them in a v-shaped mixer for 5 minutes.

[0023] (3) Add 93 kg of sieved anhydrous glucose into the above-mentioned mixture of Florfenicol and ammonium chloride, fully mix in an ordinary mixer for 20 minutes, and discharge to obtain Florfenicol powder of the present invention .

Embodiment 2

[0025] (1) Pass florfenicol, ammonium chloride and anhydrous glucose through 80-mesh sieve respectively, and set aside.

[0026] (2) Weigh 5 kg of sieved florfenicol and 15 kg of ammonium chloride, and fully mix them in a V-shaped mixer for 5 minutes.

[0027] (3) Add 80 kg of sieved anhydrous glucose into the above-mentioned mixture of Florfenicol and ammonium chloride, fully mix in an ordinary mixer for 20 minutes, and discharge to obtain Florfenicol powder of the present invention .

Embodiment 3

[0029] (1) Pass florfenicol, ammonium chloride and anhydrous glucose through 80-mesh sieve respectively, and set aside.

[0030] (2) Weigh 10kg of sieved florfenicol and 30kg of ammonium chloride, and fully mix them in a v-shaped mixer for 10 minutes.

[0031] (3) Add 60 kg of sieved anhydrous glucose into the above-mentioned mixture of Florfenicol and ammonium chloride, fully mix in an ordinary mixer for 15 minutes, and discharge to obtain Florfenicol powder of the present invention .

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PUM

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Abstract

The invention discloses a formula and a preparation method of florfenicol powder. The formula comprises the following medicines: florfenicol, medicines for relieving cough and reducing sputum, such as ammonium chloride, and anhydrous dextrose; the florfenicol powder is prepared from the following components by weight percent: 2-20% of florfenicol, 6-60% of ammonium chloride and the balance of anhydrous dextrose. According to the formula of the florfenicol powder, the florfenicol and the medicines for relieving cough and reducing sputum are adopted to carry out drug combination; the treatment effect of the whole powder is enhanced by combination of the florfenicol and the medicines; meanwhile, the water solubility of the florfenicol can be increased by ammonium chloride by reasonable proportioning of the florfenicol and the medicines for relieving cough and reducing sputum, such as the ammonium chloride in the concrete preparation process; the defect of low water solubility of the florfenicol is overcome; meanwhile, the curative effect of the florfenicol can be enhanced; and a drinking agent prepared from the florfenicol and the ammonium chloride is convenient to use, significant in curative effect, and especially high in curative effect on respiratory infection.

Description

technical field [0001] The invention relates to a florfenicol powder, in particular to a formulation of the florfenicol powder and a preparation method thereof, belonging to the technical field of veterinary drug preparation. Background technique [0002] Florfenicol is the third-generation product of chloramphenicol, which belongs to animal-specific antibiotics. Its antibacterial activity against sensitive bacteria is similar to that of chloramphenicol and thiamphenicol, but its chemical structure is different from that of chloramphenicol. Potential bone marrow suppression or aplastic anemia hazards, and still sensitive to bacteria resistant to chloramphenicol and thiamphenicol, has the characteristics of broad antibacterial spectrum, good absorption, wide distribution, safety and high efficiency. In the prevention and treatment of animal diseases, especially It is a food animal with broad application prospects. It has been listed in more than 20 countries, and China has al...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/20A61K9/14A61K47/02A61P31/04A61K31/165
Inventor 田勇王书平霍琳琳李灿王真真
Owner PIZHOU ZHENGKANG BIOTECH