Lincomycin fermentation liquor treatment process

A technology of lincomycin and treatment process, which is applied to the preparation of sugar derivatives, sugar derivatives, sugar derivatives, etc., can solve problems such as environmental pollution and waste of resources, and achieve avoidance of large quantities of discharge, reduction of processing burden, and clarity Improved effect

Inactive Publication Date: 2014-12-03
JIANGXI CLEANING MEMBRANE TECH +1
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Problems solved by technology

[0003] The purpose of the present invention is to provide a treatment process for lincomycin fermentation liquid, which can increase the y

Method used

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  • Lincomycin fermentation liquor treatment process

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Embodiment 1

[0018] Complete the lincomycin fermented liquid treatment with reference to the steps shown in the accompanying drawings, and the concrete steps are as follows:

[0019] (1) Acidify the lincomycin fermentation broth with a fermentation unit of 8000-9000u / ml, and pump it into a fully closed ceramic membrane filtration system. The precision of the ceramic membrane is 500nm, the membrane inlet pressure is 0.35-0.45MPa, and the membrane outlet pressure is 0.20 -0.30MPa, filtration temperature 50-60℃;

[0020] (2) During the ceramic membrane filtration process, when the concentration factor of the lincomycin fermentation broth is 3.5, continuously add washing water with a mass of 1.5-2.0 times the fermentation broth at a certain speed for washing until the lincomycin fermentation broth filtrate When the titer is as low as 200-300u / ml, stop the ceramic membrane filtration, and collect the ceramic membrane filtrate and bacterial residue;

[0021] (3) Concentrate and dehydrate the ce...

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Abstract

The invention discloses a lincomycin fermentation liquor treatment process. The lincomycin fermentation liquor treatment process comprises the following steps: (1) acidifying lincomycin fermentation liquor, and filtering the acidified lincomycin fermentation liquor in a ceramic membrane filter system; (2) carrying out nanofiltration, concentration and dehydration on the obtained ceramic membrane high-titer filtrate, then entering the treated ceramic membrane high-titer filtrate into a downstream production process, and returning ceramic membrane low-titer filtrate and nanofiltration filtrate to an upstream process to be recycled; and (3) collecting mushroom dregs after ceramic membrane filtration is completed, adding engineering bacteria, realizing harmless treatment, and carrying out secondary fermentation to obtain industrial yeasts. The lincomycin fermentation liquor treatment process provides strong technical support for upgrading and reconstruction of a lincomycin production enterprise, and market competitiveness of the lincomycin production enterprise is improved.

Description

technical field [0001] The invention relates to an antibiotic production process, in particular to a lincomycin fermentation liquid treatment process. Background technique [0002] In the traditional production process of lincomycin, plates, drums, and centrifuges are generally used to filter the lincomycin fermentation broth. This kind of filtration method not only has a low yield, about 90%-95%, but also the quality of the filtrate after filtration is poor. The content of impurities such as protein, colloid, and pigment in the filtrate is high, and the chromaticity and light transmittance are poor, which imposes a heavy burden on downstream processes. , resulting in low downstream process yields. In the traditional process, after the filtrate is alkalized, the organic solvent phase-inversion extraction is directly carried out, resulting in a large amount of organic solvent recycling, high consumption, high yield loss in the aqueous phase, and a large amount of wastewater ...

Claims

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Application Information

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IPC IPC(8): C07H15/16C07H1/06C12N1/16
Inventor 葛友群陈祥树余承祥
Owner JIANGXI CLEANING MEMBRANE TECH
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