Composite nano sliver polymer antibacterial micelle and preparation method thereof

A technology of composite polymer and antibacterial glue, applied in the fields of biomedical engineering, biomedical materials, and polymer chemistry, can solve the problems of reducing local concentration, destroying the activity of cell synthase, decreasing antibacterial and bactericidal properties, and avoiding organic solvents. Solvent residue issues, unique temperature sensitive properties, effects of good biocompatibility

Active Publication Date: 2014-12-03
SUN YAT SEN UNIV
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Problems solved by technology

[0003] Yet, no matter be silver ion or elemental silver antibacterial agent all there are many weak points
For example, silver ions are water-soluble and are easy to lose in solution, thereby reducing their local concentration; secondly, silver ions are chemically active, sensitive to light and heat, and prone to oxidation reactions, which also lead to a decline in their antibacterial and bactericidal properties
In addition, there are a lot of proteins and amino acids in

Method used

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  • Composite nano sliver polymer antibacterial micelle and preparation method thereof
  • Composite nano sliver polymer antibacterial micelle and preparation method thereof
  • Composite nano sliver polymer antibacterial micelle and preparation method thereof

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[0032] Such as Figure 4 As shown, the nano-silver composite polymer antibacterial micelle of the present invention is composed of methoxy-terminated polyethylene glycol-poly(acrylamide-acrylonitrile) amphiphilic block copolymer, and the antibacterial glue The structure of the bundle is a core-shell structure and is spherical. The hydrophobic section of the core contains silver nanoparticles and has UCST responsiveness. The silver nanoparticles are generated by in-situ reduction of soluble silver ions through sodium borohydride reducing agent, and are in-situ. Nano-silver particles with an average diameter of 4 nanometers are generated and uniformly dispersed in micelles with an average diameter of 40 nanometers. The soluble silver ions come from silver nitrate, and the silver ions form coordination bonds with the nitrogen and oxygen atoms in the polymer. Among them, the molar ratio of acrylamide to acrylonitrile structural units in the amphiphilic block copolymer is 5:95 to 95:...

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Abstract

The invention discloses a composite nano sliver polymer antibacterial micelle and a preparation method thereof. The antibacterial micelle takes polyethylene glycol and poly(acrylamide-co-acrylonitrile) with upper critical solution temperature (UCST) response characteristic as hydrophilic and lyophobic chain segments respectively; sliver ions are combined onto cyanogroup of a lyophobic inner core of the micelle by virtue of a coordination bond and reduced by sodium borohydride to generate nano sliver particles with an average diameter of 4 nanometers in situ, and the nano silver particles are uniformly dispersed into the micelle with the average diameter of 40 nanometers. The nano-sliver-modified polymer micelle has good biocompatibility, unique thermal response, excellent antibacterial performance, and can be used for effectively inhibiting and killing microorganisms such as escherichia coli.

Description

technical field [0001] The invention relates to a nano-silver composite polymer antibacterial micelle and a preparation method thereof, belonging to the fields of polymer chemistry, biomedical engineering and biomedical materials. Background technique [0002] Bacteria are ubiquitous, and grow, reproduce, and even mutate under certain conditions, which not only cause the decomposition, deterioration, and corruption of various materials, but also endanger human health. Therefore, how to effectively inhibit the growth and reproduction of bacteria has important practical significance. Among the many antibacterial agents, silver-based antibacterial agents have the advantages of broad spectrum, high efficiency, and resistance to drug resistance, and are widely used in various antibacterial occasions. Silver antibacterial agents are mainly divided into silver ion antibacterial agents and silver elemental antibacterial agents. There are a variety of silver ion antibacterial agent...

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Application Information

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IPC IPC(8): C08J3/05C08K3/08C08F299/00C08G65/48C08F220/56C08F220/44
Inventor 张超童国权黄岗全昌云刘杰蒋庆
Owner SUN YAT SEN UNIV
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