Composite nano sliver polymer antibacterial micelle and preparation method thereof

Abstract

The invention discloses a composite nano sliver polymer antibacterial micelle and a preparation method thereof. The antibacterial micelle takes polyethylene glycol and poly(acrylamide-co-acrylonitrile) with upper critical solution temperature (UCST) response characteristic as hydrophilic and lyophobic chain segments respectively; sliver ions are combined onto cyanogroup of a lyophobic inner core of the micelle by virtue of a coordination bond and reduced by sodium borohydride to generate nano sliver particles with an average diameter of 4 nanometers in situ, and the nano silver particles are uniformly dispersed into the micelle with the average diameter of 40 nanometers. The nano-sliver-modified polymer micelle has good biocompatibility, unique thermal response, excellent antibacterial performance, and can be used for effectively inhibiting and killing microorganisms such as escherichia coli.

Description

technical field [0001] The invention relates to a nano-silver composite polymer antibacterial micelle and a preparation method thereof, belonging to the fields of polymer chemistry, biomedical engineering and biomedical materials. Background technique [0002] Bacteria are ubiquitous, and grow, reproduce, and even mutate under certain conditions, which not only cause the decomposition, deterioration, and corruption of various materials, but also endanger human health. Therefore, how to effectively inhibit the growth and reproduction of bacteria has important practical significance. Among the many antibacterial agents, silver-based antibacterial agents have the advantages of broad spectrum, high efficiency, and resistance to drug resistance, and are widely used in various antibacterial occasions. Silver antibacterial agents are mainly divided into silver ion antibacterial agents and silver elemental antibacterial agents. There are a variety of silver ion antibacterial agent...

AI Technical Summary

Problems solved by technology

[0003] Yet, no matter be silver ion or elemental silver antibacterial agent all there are many weak points

For example, silver ions are water-soluble and are easy to lose in solution, thereby reducing their local concentration; secondly, silver ions are chemically active, sensitive to light and heat, and prone to oxidation reactions, which also lead to a decline in their antibacterial and bactericidal properties

In addition, there are a lot of proteins and amino acids in the human body, silver ions are easy to combine with sulfhydryl (-SH), amino (-NH 2 ) to form a coordination bond, coagulate the protein, destroy the activity of cell synthetase, and produce certain toxicity

There is a shortcoming that is difficult to ignore in simple silver, that is, silver simple antibacterial agents are prone to agglomeration, the rate of releasing silver is slow, and the antibacterial effect is not as good as that of silver ion antibacterial agents.

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