A local external patch containing lidocaine or its medicinal salt

A lidocaine and patch technology is applied in the directions of non-active ingredients medical preparations, anesthetics, sheet delivery, etc., and can solve problems such as cumbersome production processes and the like

Active Publication Date: 2017-07-04
BEIJING TIDE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The object of the present invention is to solve the problem that lidocaine local anesthesia patch production process is loaded down with trivial details, suppresses the problem that lidocaine crystallizes and separates out, and purpose is to obtain lidocaine containing smaller amount or lower concentration, skin irritation is little, causes Local anesthesia external patch with quick effect, suitable viscosity, good practicability and less side effects

Method used

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  • A local external patch containing lidocaine or its medicinal salt
  • A local external patch containing lidocaine or its medicinal salt
  • A local external patch containing lidocaine or its medicinal salt

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take 35.9% by weight of SIS model JSR5505P, 18% terpene resin, 4% hydrogenated rosin glyceride, 25% liquid paraffin, 0.1% BHT, 5% polybutene, 2% L -Put menthol into the mixing tank, control the temperature at 120°C, heat to dissolve, stir and mix evenly to make a paste; dissolve 10% lidocaine in the above paste, stir and mix to make a medicated paste; The body is evenly coated on the silicon-treated polyethylene terephthalate PET film, laminated with the knitted fabric or non-woven fabric as the backing of the preparation, and then cut into the set size to obtain the desired preparation .

Embodiment 2

[0030] 25% of the SIS model JSR5505P and 25% of the SIS JSR5000 model, 16% terpene resin, 4% hydrogenated rosin glyceride, 15% liquid paraffin, 0.1% BHT, 5% Put polybutene and 3% L-menthol into a mixing tank, control the temperature at 150°C, heat to dissolve, stir and mix evenly to prepare a paste; dissolve 6.9% lidocaine in the above paste, stir and mix to prepare Obtain the drug-containing ointment; apply the drug-containing ointment evenly on the silicon-treated polyethylene terephthalate PET film, and after laminating it with the knitted or non-woven fabric used as the backing of the preparation, cut it into a The desired size can be obtained.

Embodiment 3

[0032] Take 23.9% by weight of the model JSR5505P SIS, 36% terpene resin, 4% hydrogenated rosin glyceride, 20% liquid paraffin, 0.05% vitamin E, 2% polybutene, 4% L-mint Add alcohol and 0.05% calcium hydroxide to a mixing tank, control the temperature at 150°C, heat to dissolve, stir and mix evenly to make a paste; dissolve 10% lidocaine in the above paste, stir and mix to make a plaster containing ointment body; the drug-containing ointment is evenly coated on the silicon-treated polyethylene terephthalate PET film, and after laminating with the knitted fabric or non-woven fabric as the backing of the preparation, it is cut into a set size , to obtain the desired preparation.

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PUM

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Abstract

The invention discloses a partial external patch containing lidocaine or pharmaceutical salts thereof. The invention provides an external preparation of partial drug delivery, wherein an adhesive layer is laminated on a soft back liner; the adhesive layer contains styrene-isoprene-styrene segmented copolymer (SIS), tackifier resin and softer; and lidocaine as the effective component is mixed in the adhesive layer. Compared with the prior art, the preparation provided by the invention has the advantages that the transdermal absorption rate of medicines is increased; the medicines can permeate complete skin to reach a corium layer, so that superficial analgesia is realized; the medicinal effect can be generated within a short time; the particial anaesthesia effect of medicines can be achieved more rapidly; and the partial external patch provided by the invention takes effect rapidly and has good effect.

Description

technical field [0001] The invention relates to an external patch for local anesthesia, in particular to an external patch for local anesthesia containing lidocaine or a medicinal salt thereof and a preparation method thereof. Background technique [0002] Pain is an inherent subjective feeling of the human body. It is not only a simple feeling, but also a comprehensive reaction process of feeling, emotion, cognition and behavior. Pain in children refers to severe discomfort experienced or reported by individuals occurring in children. Blood drawing and venous cannulation are the most common cause of pain in hospitalized children, coupled with fear of anesthesia and medical staff, often crying and uncooperative, although medical guidelines recommend that local anesthesia be used before venous cannulation, but most of them are currently used clinically. It is an ointment or a liquid preparation. When using an ointment or a liquid preparation, there are disadvantages such as ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/167A61K47/32A61K47/34A61P23/02
Inventor 申桂芬孙立欣张丽梅肖萱周丽莹刘玉静
Owner BEIJING TIDE PHARMA
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