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Refining method of tylosin

A technology of tylosin and purification method, applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., can solve the problems of high yield and high purity, etc. Convenient, well-designed effects

Active Publication Date: 2014-12-17
河南后羿制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a method for refining tylosin to solve the problem that the existing tylosin refining technology cannot take into account high yield and high purity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The refining method of the tylosin of the present embodiment comprises the following steps:

[0022] 1) Take 1kg of crude tylosin, add 5L of methanol, stir to dissolve, then add 50g of activated carbon, heat to 60°C, stir for decolorization treatment, the treatment time is 90min, and the mixture is obtained;

[0023] 2) Suction filter the mixture, and the filter paper used is a medium-speed qualitative filter paper (the particle size of the intercepted particles is 11 μm or more), and the filtrate A is obtained;

[0024] 3) Microfiltration is performed on filtrate A, and the pore size of the microfiltration membrane used is 0.65 μm to obtain filtrate B;

[0025] 4) Ultrafiltration is performed on the filtrate B, the ultrafiltration pressure is 0.1MPa, and the molecular weight cut-off of the ultrafiltration membrane used is 5K, and the filtrate C is obtained;

[0026] 4) The filtrate C is concentrated by nanofiltration, the concentration ratio is 1.5, the nanofiltration...

Embodiment 2

[0029] The refining method of the tylosin of the present embodiment comprises the following steps:

[0030] 1) Take 1kg of crude tylosin, add 10L of methanol, stir to dissolve, then add 80g of activated carbon, heat to 70°C, stir for decolorization treatment, and the treatment time is 70min to obtain a mixture;

[0031] 2) Suction filter the mixture, and the filter paper used is a medium-speed qualitative filter paper (the particle size of the intercepted particles is 11 μm or more), and the filtrate A is obtained;

[0032] 3) Microfiltration is performed on filtrate A, and the pore size of the microfiltration membrane used is 0.45 μm to obtain filtrate B;

[0033] 4) Ultrafiltration is performed on the filtrate B, the ultrafiltration pressure is 0.15 MPa, and the molecular weight cut-off of the ultrafiltration membrane used is 10K, and the filtrate C is obtained;

[0034] 4) Concentrate the filtrate C by nanofiltration, the concentration factor is 2, the nanofiltration press...

Embodiment 3

[0037] The refining method of the tylosin of the present embodiment comprises the following steps:

[0038] 1) Take 1kg of crude tylosin, add 15L of methanol, stir to dissolve, then add 90g of activated carbon, heat to 75°C, stir for decolorization treatment, and the treatment time is 50min to obtain a mixture;

[0039] 2) Suction filter the mixture, and the filter paper used is a medium-speed qualitative filter paper (the particle size of the intercepted particles is 11 μm or more), and the filtrate A is obtained;

[0040] 3) Microfiltration is performed on filtrate A, and the pore size of the microfiltration membrane used is 0.22 μm to obtain filtrate B;

[0041] 4) Ultrafiltration is performed on the filtrate B, the ultrafiltration pressure is 0.2 MPa, and the molecular weight cut-off of the ultrafiltration membrane used is 15K, and the filtrate C is obtained;

[0042] 4) Concentrate the filtrate C by nanofiltration, the concentration factor is 2.2, the nanofiltration pres...

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Abstract

The invention discloses a refining method of tylosin. The refining method comprises the following steps: (1) dissolving coarse tylosin in an organic solvent, then adding active carbon, stirring to carry out a decoloring treatment so as to obtain a mixture; (2) filtering the mixture, namely orderly subjecting the mixture to microfiltration, ultra-filtration, and nano-filtration, then condensing the filtrate to obtain a condensed liquid; (3) spray-drying the obtained condensed liquid so as to obtain the tylosin. The provided refining method is capable of improving the purity of coarse tylosin to 99% or more by combining organic dissolution, active carbon decoloring, and multiple membrane filtration technologies. The pyrogen in tylosin is completely removed, the processed tylosin reaches the injection grade, and the yield can reach 93% to 96%. Moreover, during the refining process, no other substance is added, the probability of secondary impurity pollution is avoided, the nano-filtration can play a condensing function, the reutilization rate is high, the energy consumption during the drying process is greatly reduced, the technology is simple, the operation is convenient, and the refining method is suitable for massive industrial production.

Description

technical field [0001] The invention belongs to the technical field of tylosin, and in particular relates to a method for refining tylosin. Background technique [0002] Tylosin is a special antibiotic for livestock and poultry. It is a macrolide antibiotic obtained from the culture fluid of Streptomyces fradiae. It is recognized worldwide as the drug of choice for the treatment and prevention of mycoplasma infection in livestock and poultry, and its effect is superior to that of erythromycin, beilimycin and tiamulin. [0003] Tylosin or its tartrate and phosphate can be obtained after tylosin fermentation and extraction treatment, its purity is 85% to 95%, and the impurity content is relatively large, and the pyrogens such as endotoxin contained in it have not been completely removed. After taking medicine, it is easy to cause stress response in animals, and it is not suitable for injection. The commonly used purification methods of tylosin are mostly adding alkaline subs...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/08C07H1/06
Inventor 张听盼李建正陈建晖
Owner 河南后羿制药有限公司
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